Effects of hormone replacement therapy on magnetic resonance imaging of brain parenchyma hyperintensities in postmenopausal women
Aim： To apply 3.0 magnetic resonance imaging （MRI） to study the effects of long-term, low dose hormone replacement therapy （HRT） on the brain parenchyma of postmenopausal women. Methods： A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital wer...
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| Veröffentlicht in: | Acta pharmacologica Sinica 2009-07, Vol.30 (7), p.1065-1070 |
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| container_title | Acta pharmacologica Sinica |
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| creator | Liu, Yan-yong Hu, Ling Ji, Chao Chen, Dong-wen Shen, Xi Yang, Nan Yue, Yun Jiang, Jing-mei Hong, Xia Ge, Qin-sheng Zuo, Ping-ping |
| description | Aim： To apply 3.0 magnetic resonance imaging （MRI） to study the effects of long-term, low dose hormone replacement therapy （HRT） on the brain parenchyma of postmenopausal women.
Methods： A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital were enrolled. The HRT group was composed of 71 subjects who had been given a low dose of HRT for over 4 years, while 84 women who had never been given HRT were enrolled in the control group. The Mini-Mental State Examination （MMSE） was used to evaluate menta state, and an Enzyme-Linked ImmunoSorbent Assay （ELISA） was used to detect plasma levels of sex hormones. In addition, all participants were subjected to an MRI, including axial T2 weighted imaging （T2WI）, fluid-attenuated inversion recovery （FLAIR）, T1 weighted imaging （T1WI, oblique coronal, vertical to the hippocampus, slice thickness 3 mm without gaps）, and a 3D image of the whole brain.
Results： The ELISA showed that the plasma level of estradiol in the HRT group was significantly higher than that in the control group （P〈0.05）. No differences were observed in the MMSE between the two groups. In participants older than 70 years of age, the number of deep white matter hyperintensities （DWMHs） in the control group was significantly higher than that in the HRT group （P=0.0013）; however, in other age subgroups, no statistical differences were observed. Finally, no significant difference in periventricular hyperintensity （PVH） between the two groups was observed.
Conclusion： We found that a high plasma level of estradiol in postmenopausal women receiving long-term HRT was correlated with the survival of brain parenchyma. |
| doi_str_mv | 10.1038/aps.2009.81 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4006658</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>30813335</cqvip_id><sourcerecordid>733363911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-12924833d4bd263c6293b8fd6f38ad6e502f9d271c7537eede68221f3a9db2c63</originalsourceid><addsrcrecordid>eNp9kktv1TAQhSMEoqWwYg8WC1hALrYncZwNEqrKQ6rEBtaW40wSl8RO7QR0l_xzHO5VCwix8mO-OeMznix7zOiOUZCv9Rx3nNJ6J9md7JRVRZlXvCzupr2oWF5QCSfZgxivKAUOrL6fnbC6rMqUcpr9uOg6NEskviODD5N3SALOozY4oVvIMmDQ8554RybdO1ysSfHonXYGiU131vVbchO0dWTWAZ0Z9pMmw37GYN2CLtrFYiRb2MclyfpZr1GP5LtPh4fZvU6PER8d17Psy7uLz-cf8stP7z-ev73MTcnFkjNe80ICtEXTcgFG8Boa2bWiA6lbgSXlXd3yipmqhAqxRSE5Zx3oum24EXCWvTnozmszYWuSu6BHNYdkIuyV11b9GXF2UL3_pgpKhShlEnhxFAj-esW4qMlGg-OoHfo1qgoABNSMJfL5f0lOa4BC8AQ--wu88mtwqQ2KM6BApYAEvTxAJvgYA3Y3b2ZUbROg0gSobQKU3Go_-d3mLXv88gS8OgAxhVyP4bbmv_WeHnCnlzXgjV5iNuQXcTRhBu_666SpGm2-dnZElRyw1JYSfgKQV9So</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213030863</pqid></control><display><type>article</type><title>Effects of hormone replacement therapy on magnetic resonance imaging of brain parenchyma hyperintensities in postmenopausal women</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Liu, Yan-yong ; Hu, Ling ; Ji, Chao ; Chen, Dong-wen ; Shen, Xi ; Yang, Nan ; Yue, Yun ; Jiang, Jing-mei ; Hong, Xia ; Ge, Qin-sheng ; Zuo, Ping-ping</creator><creatorcontrib>Liu, Yan-yong ; Hu, Ling ; Ji, Chao ; Chen, Dong-wen ; Shen, Xi ; Yang, Nan ; Yue, Yun ; Jiang, Jing-mei ; Hong, Xia ; Ge, Qin-sheng ; Zuo, Ping-ping</creatorcontrib><description>Aim： To apply 3.0 magnetic resonance imaging （MRI） to study the effects of long-term, low dose hormone replacement therapy （HRT） on the brain parenchyma of postmenopausal women.
Methods： A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital were enrolled. The HRT group was composed of 71 subjects who had been given a low dose of HRT for over 4 years, while 84 women who had never been given HRT were enrolled in the control group. The Mini-Mental State Examination （MMSE） was used to evaluate menta state, and an Enzyme-Linked ImmunoSorbent Assay （ELISA） was used to detect plasma levels of sex hormones. In addition, all participants were subjected to an MRI, including axial T2 weighted imaging （T2WI）, fluid-attenuated inversion recovery （FLAIR）, T1 weighted imaging （T1WI, oblique coronal, vertical to the hippocampus, slice thickness 3 mm without gaps）, and a 3D image of the whole brain.
Results： The ELISA showed that the plasma level of estradiol in the HRT group was significantly higher than that in the control group （P〈0.05）. No differences were observed in the MMSE between the two groups. In participants older than 70 years of age, the number of deep white matter hyperintensities （DWMHs） in the control group was significantly higher than that in the HRT group （P=0.0013）; however, in other age subgroups, no statistical differences were observed. Finally, no significant difference in periventricular hyperintensity （PVH） between the two groups was observed.
Conclusion： We found that a high plasma level of estradiol in postmenopausal women receiving long-term HRT was correlated with the survival of brain parenchyma.</description><identifier>ISSN: 1671-4083</identifier><identifier>EISSN: 1745-7254</identifier><identifier>DOI: 10.1038/aps.2009.81</identifier><identifier>PMID: 19575009</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Aged ; Aged, 80 and over ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Brain - anatomy & histology ; Brain - drug effects ; Brain - metabolism ; Estradiol - blood ; Estradiol - pharmacology ; Female ; Hormone Replacement Therapy ; Humans ; Immunology ; Internal Medicine ; Magnetic Resonance Imaging ; Medical Microbiology ; Mental Status Schedule ; Middle Aged ; Original ; original-article ; Pharmacology/Toxicology ; Vaccine ; 磁共振成像 ; 绝经后 ; 高密度</subject><ispartof>Acta pharmacologica Sinica, 2009-07, Vol.30 (7), p.1065-1070</ispartof><rights>CPS and SIMM 2009</rights><rights>Copyright Nature Publishing Group Jul 2009</rights><rights>Copyright © 2009 CPS and SIMM 2009 CPS and SIMM</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-12924833d4bd263c6293b8fd6f38ad6e502f9d271c7537eede68221f3a9db2c63</citedby><cites>FETCH-LOGICAL-c526t-12924833d4bd263c6293b8fd6f38ad6e502f9d271c7537eede68221f3a9db2c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/95561A/95561A.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006658/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006658/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19575009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yan-yong</creatorcontrib><creatorcontrib>Hu, Ling</creatorcontrib><creatorcontrib>Ji, Chao</creatorcontrib><creatorcontrib>Chen, Dong-wen</creatorcontrib><creatorcontrib>Shen, Xi</creatorcontrib><creatorcontrib>Yang, Nan</creatorcontrib><creatorcontrib>Yue, Yun</creatorcontrib><creatorcontrib>Jiang, Jing-mei</creatorcontrib><creatorcontrib>Hong, Xia</creatorcontrib><creatorcontrib>Ge, Qin-sheng</creatorcontrib><creatorcontrib>Zuo, Ping-ping</creatorcontrib><title>Effects of hormone replacement therapy on magnetic resonance imaging of brain parenchyma hyperintensities in postmenopausal women</title><title>Acta pharmacologica Sinica</title><addtitle>Acta Pharmacol Sin</addtitle><addtitle>Acta Pharmacologica Sinica</addtitle><description>Aim： To apply 3.0 magnetic resonance imaging （MRI） to study the effects of long-term, low dose hormone replacement therapy （HRT） on the brain parenchyma of postmenopausal women.
Methods： A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital were enrolled. The HRT group was composed of 71 subjects who had been given a low dose of HRT for over 4 years, while 84 women who had never been given HRT were enrolled in the control group. The Mini-Mental State Examination （MMSE） was used to evaluate menta state, and an Enzyme-Linked ImmunoSorbent Assay （ELISA） was used to detect plasma levels of sex hormones. In addition, all participants were subjected to an MRI, including axial T2 weighted imaging （T2WI）, fluid-attenuated inversion recovery （FLAIR）, T1 weighted imaging （T1WI, oblique coronal, vertical to the hippocampus, slice thickness 3 mm without gaps）, and a 3D image of the whole brain.
Results： The ELISA showed that the plasma level of estradiol in the HRT group was significantly higher than that in the control group （P〈0.05）. No differences were observed in the MMSE between the two groups. In participants older than 70 years of age, the number of deep white matter hyperintensities （DWMHs） in the control group was significantly higher than that in the HRT group （P=0.0013）; however, in other age subgroups, no statistical differences were observed. Finally, no significant difference in periventricular hyperintensity （PVH） between the two groups was observed.
Conclusion： We found that a high plasma level of estradiol in postmenopausal women receiving long-term HRT was correlated with the survival of brain parenchyma.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain - anatomy & histology</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Estradiol - blood</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Hormone Replacement Therapy</subject><subject>Humans</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical Microbiology</subject><subject>Mental Status Schedule</subject><subject>Middle Aged</subject><subject>Original</subject><subject>original-article</subject><subject>Pharmacology/Toxicology</subject><subject>Vaccine</subject><subject>磁共振成像</subject><subject>绝经后</subject><subject>高密度</subject><issn>1671-4083</issn><issn>1745-7254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kktv1TAQhSMEoqWwYg8WC1hALrYncZwNEqrKQ6rEBtaW40wSl8RO7QR0l_xzHO5VCwix8mO-OeMznix7zOiOUZCv9Rx3nNJ6J9md7JRVRZlXvCzupr2oWF5QCSfZgxivKAUOrL6fnbC6rMqUcpr9uOg6NEskviODD5N3SALOozY4oVvIMmDQ8554RybdO1ysSfHonXYGiU131vVbchO0dWTWAZ0Z9pMmw37GYN2CLtrFYiRb2MclyfpZr1GP5LtPh4fZvU6PER8d17Psy7uLz-cf8stP7z-ev73MTcnFkjNe80ICtEXTcgFG8Boa2bWiA6lbgSXlXd3yipmqhAqxRSE5Zx3oum24EXCWvTnozmszYWuSu6BHNYdkIuyV11b9GXF2UL3_pgpKhShlEnhxFAj-esW4qMlGg-OoHfo1qgoABNSMJfL5f0lOa4BC8AQ--wu88mtwqQ2KM6BApYAEvTxAJvgYA3Y3b2ZUbROg0gSobQKU3Go_-d3mLXv88gS8OgAxhVyP4bbmv_WeHnCnlzXgjV5iNuQXcTRhBu_666SpGm2-dnZElRyw1JYSfgKQV9So</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Liu, Yan-yong</creator><creator>Hu, Ling</creator><creator>Ji, Chao</creator><creator>Chen, Dong-wen</creator><creator>Shen, Xi</creator><creator>Yang, Nan</creator><creator>Yue, Yun</creator><creator>Jiang, Jing-mei</creator><creator>Hong, Xia</creator><creator>Ge, Qin-sheng</creator><creator>Zuo, Ping-ping</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090701</creationdate><title>Effects of hormone replacement therapy on magnetic resonance imaging of brain parenchyma hyperintensities in postmenopausal women</title><author>Liu, Yan-yong ; Hu, Ling ; Ji, Chao ; Chen, Dong-wen ; Shen, Xi ; Yang, Nan ; Yue, Yun ; Jiang, Jing-mei ; Hong, Xia ; Ge, Qin-sheng ; Zuo, Ping-ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-12924833d4bd263c6293b8fd6f38ad6e502f9d271c7537eede68221f3a9db2c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain - anatomy & histology</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Estradiol - blood</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Hormone Replacement Therapy</topic><topic>Humans</topic><topic>Immunology</topic><topic>Internal Medicine</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical Microbiology</topic><topic>Mental Status Schedule</topic><topic>Middle Aged</topic><topic>Original</topic><topic>original-article</topic><topic>Pharmacology/Toxicology</topic><topic>Vaccine</topic><topic>磁共振成像</topic><topic>绝经后</topic><topic>高密度</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yan-yong</creatorcontrib><creatorcontrib>Hu, Ling</creatorcontrib><creatorcontrib>Ji, Chao</creatorcontrib><creatorcontrib>Chen, Dong-wen</creatorcontrib><creatorcontrib>Shen, Xi</creatorcontrib><creatorcontrib>Yang, Nan</creatorcontrib><creatorcontrib>Yue, Yun</creatorcontrib><creatorcontrib>Jiang, Jing-mei</creatorcontrib><creatorcontrib>Hong, Xia</creatorcontrib><creatorcontrib>Ge, Qin-sheng</creatorcontrib><creatorcontrib>Zuo, Ping-ping</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta pharmacologica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yan-yong</au><au>Hu, Ling</au><au>Ji, Chao</au><au>Chen, Dong-wen</au><au>Shen, Xi</au><au>Yang, Nan</au><au>Yue, Yun</au><au>Jiang, Jing-mei</au><au>Hong, Xia</au><au>Ge, Qin-sheng</au><au>Zuo, Ping-ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of hormone replacement therapy on magnetic resonance imaging of brain parenchyma hyperintensities in postmenopausal women</atitle><jtitle>Acta pharmacologica Sinica</jtitle><stitle>Acta Pharmacol Sin</stitle><addtitle>Acta Pharmacologica Sinica</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>30</volume><issue>7</issue><spage>1065</spage><epage>1070</epage><pages>1065-1070</pages><issn>1671-4083</issn><eissn>1745-7254</eissn><abstract>Aim： To apply 3.0 magnetic resonance imaging （MRI） to study the effects of long-term, low dose hormone replacement therapy （HRT） on the brain parenchyma of postmenopausal women.
Methods： A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital were enrolled. The HRT group was composed of 71 subjects who had been given a low dose of HRT for over 4 years, while 84 women who had never been given HRT were enrolled in the control group. The Mini-Mental State Examination （MMSE） was used to evaluate menta state, and an Enzyme-Linked ImmunoSorbent Assay （ELISA） was used to detect plasma levels of sex hormones. In addition, all participants were subjected to an MRI, including axial T2 weighted imaging （T2WI）, fluid-attenuated inversion recovery （FLAIR）, T1 weighted imaging （T1WI, oblique coronal, vertical to the hippocampus, slice thickness 3 mm without gaps）, and a 3D image of the whole brain.
Results： The ELISA showed that the plasma level of estradiol in the HRT group was significantly higher than that in the control group （P〈0.05）. No differences were observed in the MMSE between the two groups. In participants older than 70 years of age, the number of deep white matter hyperintensities （DWMHs） in the control group was significantly higher than that in the HRT group （P=0.0013）; however, in other age subgroups, no statistical differences were observed. Finally, no significant difference in periventricular hyperintensity （PVH） between the two groups was observed.
Conclusion： We found that a high plasma level of estradiol in postmenopausal women receiving long-term HRT was correlated with the survival of brain parenchyma.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19575009</pmid><doi>10.1038/aps.2009.81</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Animals Biomedical and Life Sciences Biomedicine Brain - anatomy & histology Brain - drug effects Brain - metabolism Estradiol - blood Estradiol - pharmacology Female Hormone Replacement Therapy Humans Immunology Internal Medicine Magnetic Resonance Imaging Medical Microbiology Mental Status Schedule Middle Aged Original original-article Pharmacology/Toxicology Vaccine 磁共振成像 绝经后 高密度 |
| title | Effects of hormone replacement therapy on magnetic resonance imaging of brain parenchyma hyperintensities in postmenopausal women |
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