RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats

Aim: To test the role of the Beclin 1-dependent autophagy pathway in brain damage during cerebral ischemia. Methods: Focal cerebral ischemia was established in rats using a middle cerebral artery occlusion (MCAO) model. A lentiviral vector-associated RNA interference (RNAi) system was stereotaxicall...

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Veröffentlicht in:	Acta pharmacologica Sinica 2009-07, Vol.30 (7), p.919-927
Hauptverfasser:	Zheng, Yong-qiu, Liu, Jian-xun, Li, Xin-zhi, Xu, Li, Xu, Yong-gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Beclin-1 Behavior, Animal - physiology Biomedical and Life Sciences Biomedicine Brain Ischemia - metabolism Brain Ischemia - pathology Cell Differentiation - physiology Doublecortin Protein Down-Regulation Immunology Infarction, Middle Cerebral Artery Internal Medicine Lateral Ventricles - metabolism Male Medical Microbiology Neurons - cytology Neurons - metabolism Original original-article Pharmacology/Toxicology Rats Rats, Sprague-Dawley RNA Interference Stem Cells - metabolism Vaccine
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