Effect of sugar positions in ginsenosides and their inhibitory potency on Na^＋/K^＋-ATPase activity

Aim： To determine whether ginsenosides with various sugar attachments may act as active components responsible for the cardiac therapeutic effects of ginseng and sanqi （the roots of Panax ginseng and Panax notoginseng） via the same molecular mechanism triggered by cardiac glycosides, such as ouabain...

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Veröffentlicht in:	Acta pharmacologica Sinica 2009-01, Vol.30 (1), p.61-69
Hauptverfasser:	Chen, Ronald JY, Chung, Tse-yu, Li, Feng-yin, Lin, Nan-hei, Tzen, Jason TC
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biomedical and Life Sciences Biomedicine Carbohydrates - chemistry Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - metabolism Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Ginsenosides - chemistry Ginsenosides - metabolism Humans Immunology Internal Medicine Medical Microbiology Medicine, Chinese Traditional Models, Molecular Molecular Structure Original original-article Ouabain - chemistry Ouabain - metabolism Panax - chemistry Panax notoginseng - chemistry Pharmacology/Toxicology Protein Conformation Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Sodium-Potassium-Exchanging ATPase - metabolism Structure-Activity Relationship Vaccine 强心剂治疗学药理学钠离子钾离子
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