Ubiquitin Signals Proteolysis-Independent Stripping of Transcription Factors

Ubiquitination of transcription activators has been reported to regulate transcription via both proteolytic and nonproteolytic routes, yet the function of the ubiquitin (Ub) signal in the nonproteolytic process is poorly understood. By use of the heterologous transcription activator LexA-VP16 in Sac...

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Veröffentlicht in:	Molecular cell 2014-03, Vol.53 (6), p.893-903
Hauptverfasser:	Ndoja, Ada, Cohen, Robert E., Yao, Tingting
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism adenosinetriphosphatase Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Binding Sites Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor DNA DNA - genetics DNA - metabolism Humans mammals Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Proteolysis Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Signal Transduction Smad Proteins, Receptor-Regulated - genetics Smad Proteins, Receptor-Regulated - metabolism transactivators transcription (genetics) Transcription, Genetic Transcriptional Activation ubiquitin Ubiquitin - genetics Ubiquitin - metabolism Ubiquitination Valosin Containing Protein yeasts
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