Prolonged blockade of VEGF receptors does not damage retinal photoreceptors or ganglion cells

It has recently been reported that relatively short‐term inhibition of vascular endothelial growth factor (VEGF) signaling can cause photoreceptor cell death, a potentially clinically important finding since VEGF blockade has become an important modality of treatment of ocular neovascularization and...

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Veröffentlicht in:	Journal of cellular physiology 2010-07, Vol.224 (1), p.262-272
Hauptverfasser:	Miki, Akiko, Miki, Katsuaki, Ueno, Shinji, Wersinger, Delphine M. Bonnet, Berlinicke, Cynthia, Shaw, Gillian C., Usui, Shinichi, Wang, Yuxia, Zack, Donald J., Campochiaro, Peter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - toxicity Animals Antagonists Cell death Cell Survival - drug effects Cell viability Cells, Cultured Damage Dose-Response Relationship, Drug Edema Electroretinograms Electroretinography Growth factors Indoles - administration & dosage Indoles - toxicity Injections Kinases Mice Mice, Inbred C57BL Mice, Transgenic Phosphorylation Photoreception Photoreceptor Cells, Vertebrate - drug effects Photoreceptor Cells, Vertebrate - metabolism Photoreceptor Cells, Vertebrate - pathology Photoreceptors Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - toxicity Proto-Oncogene Proteins c-akt - metabolism Rats Receptors Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors Receptors, Vascular Endothelial Growth Factor - genetics Receptors, Vascular Endothelial Growth Factor - metabolism Retina Retinal ganglion cells Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - pathology Retinal Neovascularization - genetics Retinal Neovascularization - metabolism Retinal Neovascularization - pathology Retinal Neovascularization - prevention & control Signal Transduction - drug effects Thickness Time Factors Toxicity Transgenic mice Vascular diseases Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascularization
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