SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways

Superoxide dismutase (SOD) enzymes are indispensable and ubiquitous antioxidant defenses maintaining the steady-state levels of O2·(-); no wonder, thus, that their mimics are remarkably efficacious in essentially any animal model of oxidative stress injuries thus far explored. Structure-activity rel...

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Veröffentlicht in:	Antioxidants & redox signaling 2014-05, Vol.20 (15), p.2372-2415
Hauptverfasser:	Batinic-Haberle, Ines, Tovmasyan, Artak, Roberts, Emily R H, Vujaskovic, Zeljko, Leong, Kam W, Spasojevic, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Design Forum Review Humans Metalloporphyrins - chemistry Metalloporphyrins - metabolism Metalloporphyrins - pharmacology Molecular Mimicry Oxidation-Reduction - drug effects Signal Transduction - drug effects Structure-Activity Relationship Superoxide Dismutase - chemistry Superoxide Dismutase - metabolism Superoxide Dismutase - pharmacology Superoxide Dismutase - therapeutic use
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