The requirement for Cdc48/p97 in nuclear protein quality control degradation depends on the substrate and correlates with substrate insolubility

Cdc48, known as p97 or valosin-containing protein (VCP) in mammals, is an abundant AAA-ATPase that is essential for many ubiquitin-dependent processes. One well-documented role for Cdc48 is in facilitating the delivery of ubiquitylated misfolded endoplasmic reticulum proteins to the proteasome for d...

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Veröffentlicht in:	Journal of cell science 2014-05, Vol.127 (Pt 9), p.1980-1991
Hauptverfasser:	Gallagher, Pamela S, Clowes Candadai, Sarah V, Gardner, Richard G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Protein Folding Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Solubility Ubiquitin - genetics Ubiquitin - metabolism Ubiquitin-Protein Ligases - metabolism Valosin Containing Protein
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