GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells

Parallel visual pathways are initiated at the first retinal synapse by signaling between the rod and cone photoreceptors and two general classes of bipolar cells. For normal function, ON or depolarizing bipolar cells (DBCs) require the G-protein-coupled receptor, mGluR6, an intact G-protein-coupled...

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Veröffentlicht in:	The Journal of neuroscience 2014-04, Vol.34 (18), p.6334-6343
Hauptverfasser:	Ray, Thomas A, Heath, Kathryn M, Hasan, Nazarul, Noel, Jennifer M, Samuels, Ivy S, Martemyanov, Kirill A, Peachey, Neal S, McCall, Maureen A, Gregg, Ronald G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Capsaicin - pharmacology Cell Line, Transformed Excitatory Amino Acid Antagonists - pharmacology Gene Expression Regulation - genetics Gene Expression Regulation - physiology Glycine - analogs & derivatives Glycine - pharmacology Glycine Agents - pharmacology Humans In Vitro Techniques Mice Mice, Inbred C57BL Mice, Transgenic Proteoglycans - metabolism Receptors, G-Protein-Coupled - metabolism Receptors, GABA-A - genetics Receptors, Metabotropic Glutamate - metabolism Retina - cytology Retina - metabolism Retinal Bipolar Cells - cytology Retinal Bipolar Cells - drug effects Retinal Bipolar Cells - metabolism Signal Transduction - genetics Signal Transduction - physiology Strychnine - pharmacology TRPM Cation Channels - genetics TRPM Cation Channels - metabolism
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