Human uterine and placental arteries exhibit tissue-specific acute responses to 17β-estradiol and estrogen-receptor-specific agonists

The discrete regulation of vascular tone in the human uterine and placental circulations is a key determinant of appropriate uteroplacental blood perfusion and pregnancy success. Humoral factors such as estrogen, which increases in the placenta and maternal circulation throughout human pregnancy, ma...

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Veröffentlicht in:	Molecular human reproduction 2014-05, Vol.20 (5), p.433-441
Hauptverfasser:	Corcoran, Jemma J., Nicholson, Christopher, Sweeney, Michèle, Charnock, Jayne C., Robson, Stephen C., Westwood, Melissa, Taggart, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium Channel Agonists - pharmacology Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - metabolism Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - metabolism Estradiol - pharmacology Estrogen Receptor alpha - drug effects Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen Receptor beta - drug effects Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism Estrogens - pharmacology Female Humans Nitric Oxide - metabolism Placenta - blood supply Pregnancy RNA, Messenger - metabolism Uterine Artery - drug effects Uterine Artery - metabolism Vasodilation - drug effects Vasodilator Agents - pharmacology
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