A novel Netrin-1-sensitive mechanism promotes local SNARE-mediated exocytosis during axon branching

Developmental axon branching dramatically increases synaptic capacity and neuronal surface area. Netrin-1 promotes branching and synaptogenesis, but the mechanism by which Netrin-1 stimulates plasma membrane expansion is unknown. We demonstrate that SNARE-mediated exocytosis is a prerequisite for ax...

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Veröffentlicht in:	The Journal of cell biology 2014-04, Vol.205 (2), p.217-232
Hauptverfasser:	Winkle, Cortney C, McClain, Leslie M, Valtschanoff, Juli G, Park, Charles S, Maglione, Christopher, Gupton, Stephanie L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - genetics Carrier Proteins - metabolism Cellular biology Cerebral Cortex - cytology Cerebral Cortex - metabolism Exocytosis - physiology Humans Membranes Mice Mice, Knockout Nerve Growth Factors - genetics Nerve Growth Factors - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Netrin-1 Neurochemistry Neurons Neurons - cytology Neurons - metabolism Proteins Synaptosomal-Associated Protein 25 - genetics Synaptosomal-Associated Protein 25 - metabolism Tripartite Motif Proteins Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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