Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production and decreasing proinflammatory cytokine secretion via the PI3K/Akt/GSK3β pathway

Approaches for controlling inflammatory responses and reducing the mortality rate of septic patients remain clinically ineffective; new drugs need to be identified that can induce anti-inflammatory responses. Ephedrine hydrochloride （EH） is a compound that is widely used in cardiovascular diseases,...

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Veröffentlicht in:	Cellular & molecular immunology 2013-07, Vol.10 (4), p.330-337
Hauptverfasser:	Zheng, Yuejuan, Yang, Yang, Li, Yuhu, Xu, Limin, Wang, Yi, Guo, Ziyi, Song, Haiyan, Yang, Muyi, Luo, Beier, Zheng, Aoxiang, Li, Ping, Zhang, Yan, Ji, Guang, Yu, Yizhi
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Anesthesia Animals Anti-inflammatory agents Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Antibodies Antihypertensives Biomedical and Life Sciences Biomedicine Cardiovascular diseases Cell Line Cell walls Cytokines Cytokines - metabolism Disease Models, Animal Ephedrine Ephedrine - administration & dosage Ephedrine - pharmacology Female Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Humans Hypotension IL-10 IL-1β Immunology Immunosuppressive agents Inflammation Inflammation Mediators - metabolism Interleukin 10 Interleukin 12 Interleukin 6 Interleukin-10 - metabolism Macrophages Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Medical Microbiology Mice Mice, Inbred C57BL Microbiology Overdose Peptidoglycan - administration & dosage Peptidoglycan - immunology Peptidoglycans Peritonitis Peritonitis - chemically induced Peritonitis - drug therapy Peritonitis - immunology Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism research-article Sepsis - drug therapy Sepsis - immunology Signal Transduction - drug effects Tumor necrosis factor-α Tumors Vaccine 分泌平衡生产炎性细胞因子炎症反应盐酸麻黄碱磷脂酰肌醇3激酶诱导
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