Quercetin protects rat dorsal root ganglion neurons against high glucose-induced injury in vitro through Nrf-2/HO-1 activation and NF-κB inhibition

Aim： To examine the effects of quercetin, a natural antioxidant, on high glucose （HG）-induced apoptosis of cultured dorsal root ganglion （DRG） neurons of rats. Methods： DRG neurons exposed to HG （45 mmol/L） for 24 h were employed as an in vitro model of diabetic neuropathy. Cell viability, reactive...

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Veröffentlicht in:	Acta pharmacologica Sinica 2013-09, Vol.34 (9), p.1140-1148
Hauptverfasser:	Shi, Yue, Liang, Xiao-chun, Zhang, Hong, Wu, Qun-li, Qu, Ling, Sun, Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Dose-Response Relationship, Drug Enzyme Activation - drug effects Enzyme Activation - physiology Female Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Ganglia, Spinal - pathology Glucose - toxicity Heme Oxygenase (Decyclizing) - biosynthesis Immunology Internal Medicine Medical Microbiology Neurons - drug effects Neurons - metabolism Neurons - physiology Neuroprotective Agents - pharmacology NF-E2-Related Factor 2 - biosynthesis NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Original original-article Pharmacology/Toxicology Pregnancy Quercetin - pharmacology Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Vaccine 体外大鼠损伤槲皮素激活背根神经节神经元诱导培养高糖
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