Development of ionic-complex-based nanostructured lipid carriers to improve the pharmacokinetic profiles of breviscapine

Aim： Breviscapine isolated from the Chinese herb Erigeron breviscapus （Vant） Hand-Mazz is widely used to treat cardiovascular and cerebrovascular diseases. The aim of this study was to improve the pharmacokinetic profiles of breviscapine using nanostructured lipid carrier based on an ionic complex f...

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Veröffentlicht in:	Acta pharmacologica Sinica 2013-08, Vol.34 (8), p.1108-1115
Hauptverfasser:	Li, Mei, Zheng, Yong, Shan, Feng-ying, Zhou, Jing, Gong, Tao, Zhang, Zhi-rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Chemistry, Pharmaceutical - methods Drug Carriers - chemical synthesis Drug Carriers - pharmacokinetics Flavonoids - blood Flavonoids - chemical synthesis Flavonoids - pharmacokinetics Immunology Internal Medicine Macromolecular Substances - chemical synthesis Macromolecular Substances - chemistry Macromolecular Substances - pharmacokinetics Male Medical Microbiology Nanostructures - chemistry Original original-article Particle Size Pharmacology/Toxicology Phospholipids - blood Phospholipids - chemical synthesis Phospholipids - pharmacokinetics Rats Rats, Wistar Vaccine 体内药代动力学灯盏花素离子纳米结构脂质联络委员会载体透射电子显微镜
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