Effects of triptolide on RIZ1 expression, proliferation, and apoptosis in multiple myeloma U266 cells

Aim： To investigate the effects of triptolide on proliferation and apoptosis as well as on the expression of RIZ1 in the human multiple myeloma cell line U266 in vitro. Methods： The effect of triptolide on the growth of U266 cells was studied by MTi- assay. Apoptosis was detected by Hoechst 33258 st...

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Veröffentlicht in:	Acta pharmacologica Sinica 2010-06, Vol.31 (6), p.733-740
Hauptverfasser:	Zhao, Fei, Chen, Yan, Zeng, Ling-lan, Li, Rui, Zeng, Rong, Wen, Lu, Liu, Yuan, Zhang, Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin Antineoplastic Agents, Alkylating - pharmacology Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Bisbenzimidazole - analysis Blotting, Western caspase Cell Line, Tumor Cell Proliferation - drug effects Diterpenes - pharmacology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drugs, Chinese Herbal - pharmacology Epoxy Compounds - pharmacology Flow Cytometry Fluorescent Dyes - analysis Histone-Lysine N-Methyltransferase Histones - metabolism Humans Immunology Inhibitor of Apoptosis Proteins - genetics Internal Medicine Medical Microbiology Methylation Multiple Myeloma - drug therapy Multiple Myeloma - genetics Multiple Myeloma - pathology Nuclear Proteins - genetics Nuclear Proteins - metabolism Original original-article PCR检测 Pharmacology/Toxicology Phenanthrenes - pharmacology Transcription Factors - genetics Transcription Factors - metabolism Vaccine 多发性骨髓瘤浓度依赖性细胞凋亡细胞增殖雷公藤甲素
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