Mesenchymal stem cells transplantation suppresses inflammatory responses in global cerebral ischemia: contribution of TNF-α-induced protein 6

Aim: To investigate the effects of mesenchymal stem cells (MSCs) transplantation on rat global cerebral ischemia and the underlying mechanisms. Methods: Adult male SD rats underwent asphxial cardiac arrest to induce global cerebral ischemia, then received intravenous injection of 5×10 6 cultured MSC...

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Veröffentlicht in:	Acta pharmacologica Sinica 2013-06, Vol.34 (6), p.784-792
Hauptverfasser:	Lin, Qing-ming, Zhao, Shen, Zhou, Li-li, Fang, Xiang-shao, Fu, Yue, Huang, Zi-tong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Blotting, Western Brain Ischemia - physiopathology Brain Ischemia - therapy Cell Adhesion Molecules - administration & dosage Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cerebral Cortex - metabolism Cerebral Cortex - pathology Disease Models, Animal Enzyme-Linked Immunosorbent Assay Immunology Inflammation - pathology Inflammation - therapy Inflammation Mediators - metabolism Injections, Intravenous Internal Medicine Leukocyte Elastase - genetics Leukocyte Elastase - metabolism Male Medical Microbiology Mesenchymal Stem Cell Transplantation - methods Original original-article Pharmacology/Toxicology Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction S100 Calcium Binding Protein beta Subunit - blood Time Factors Treatment Outcome Up-Regulation Vaccine
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