Autophagy modulation as a target for anticancer drug discovery
an evolutionarily conserved catabolic process involving the engulfment and degradation of non-essential or abnormal cel- lular organelles and proteins, is crucial for homeostatic maintenance in living cells. This highly regulated, multi-step process has been implicated in diverse diseases including...
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| Veröffentlicht in: | Acta pharmacologica Sinica 2013-05, Vol.34 (5), p.612-624 |
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| container_title | Acta pharmacologica Sinica |
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| creator | Li, Xin Xu, Huai-long Liu, Yong-xi An, Na Zhao, Si Bao, Jin-ku |
| description | an evolutionarily conserved catabolic process involving the engulfment and degradation of non-essential or abnormal cel- lular organelles and proteins, is crucial for homeostatic maintenance in living cells. This highly regulated, multi-step process has been implicated in diverse diseases including cancer. Autophagy can function as either a promoter or a suppressor of cancer, which makes it a promising and challenging therapeutic target. Herein, we overview the regulatory mechanisms and dual roles of autophagy in cancer. We also describe some of the representative agents that exert their anticancer effects by regulating autophagy. Additionally, some emerging strategies aimed at modulating autophagy are discussed as having the potential for future anticancer drug discovery. In summary, these findings will provide valuable information to better utilize autophagy in the future development of anticancer thera- peutics that meet clinical requirements. |
| doi_str_mv | 10.1038/aps.2013.23 |
| format | Article |
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This highly regulated, multi-step process has been implicated in diverse diseases including cancer. Autophagy can function as either a promoter or a suppressor of cancer, which makes it a promising and challenging therapeutic target. Herein, we overview the regulatory mechanisms and dual roles of autophagy in cancer. We also describe some of the representative agents that exert their anticancer effects by regulating autophagy. Additionally, some emerging strategies aimed at modulating autophagy are discussed as having the potential for future anticancer drug discovery. In summary, these findings will provide valuable information to better utilize autophagy in the future development of anticancer thera- peutics that meet clinical requirements.</description><identifier>ISSN: 1671-4083</identifier><identifier>EISSN: 1745-7254</identifier><identifier>DOI: 10.1038/aps.2013.23</identifier><identifier>PMID: 23564085</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; Autophagy - drug effects ; Biomedical and Life Sciences ; Biomedicine ; Drug Discovery - methods ; Humans ; Immunology ; Internal Medicine ; Medical Microbiology ; MicroRNAs - genetics ; Neoplasms - drug therapy ; Neoplasms - genetics ; Neoplasms - metabolism ; Pharmacology/Toxicology ; Review ; Vaccine ; 代谢过程 ; 体内平衡 ; 制作 ; 抗癌作用 ; 抗癌药物 ; 监管机制 ; 自噬 ; 药物发现</subject><ispartof>Acta pharmacologica Sinica, 2013-05, Vol.34 (5), p.612-624</ispartof><rights>CPS and SIMM 2013</rights><rights>Copyright Nature Publishing Group May 2013</rights><rights>Copyright © 2013 CPS and SIMM 2013 CPS and SIMM</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-501b00006321aeef36053bb7627b9df18e4a33a2b0d1e5c2a00308f5d1ff4ee3</citedby><cites>FETCH-LOGICAL-c505t-501b00006321aeef36053bb7627b9df18e4a33a2b0d1e5c2a00308f5d1ff4ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/95561A/95561A.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002878/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002878/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23564085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xin</creatorcontrib><creatorcontrib>Xu, Huai-long</creatorcontrib><creatorcontrib>Liu, Yong-xi</creatorcontrib><creatorcontrib>An, Na</creatorcontrib><creatorcontrib>Zhao, Si</creatorcontrib><creatorcontrib>Bao, Jin-ku</creatorcontrib><title>Autophagy modulation as a target for anticancer drug discovery</title><title>Acta pharmacologica Sinica</title><addtitle>Acta Pharmacol Sin</addtitle><addtitle>Acta Pharmacologica Sinica</addtitle><description>an evolutionarily conserved catabolic process involving the engulfment and degradation of non-essential or abnormal cel- lular organelles and proteins, is crucial for homeostatic maintenance in living cells. This highly regulated, multi-step process has been implicated in diverse diseases including cancer. Autophagy can function as either a promoter or a suppressor of cancer, which makes it a promising and challenging therapeutic target. Herein, we overview the regulatory mechanisms and dual roles of autophagy in cancer. We also describe some of the representative agents that exert their anticancer effects by regulating autophagy. Additionally, some emerging strategies aimed at modulating autophagy are discussed as having the potential for future anticancer drug discovery. In summary, these findings will provide valuable information to better utilize autophagy in the future development of anticancer thera- peutics that meet clinical requirements.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Autophagy - drug effects</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Drug Discovery - methods</subject><subject>Humans</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Medical Microbiology</subject><subject>MicroRNAs - genetics</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Pharmacology/Toxicology</subject><subject>Review</subject><subject>Vaccine</subject><subject>代谢过程</subject><subject>体内平衡</subject><subject>制作</subject><subject>抗癌作用</subject><subject>抗癌药物</subject><subject>监管机制</subject><subject>自噬</subject><subject>药物发现</subject><issn>1671-4083</issn><issn>1745-7254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkk1r3DAQhkVpadK0p96LSy-F1tuRxrLlSyCEfkGgl9zF2B57HbzSRrID---jZbdLWgrVRULz6J2PV0K8lbCSgOYLbeNKgcSVwmfiXFaFziuli-fpXFYyL8DgmXgV4x0AKpT1S3GmUJfpXp-Ly6tl9ts1Dbts47tlonn0LqOYUTZTGHjOeh8ycvPYkms5ZF1YhqwbY-sfOOxeixc9TZHfHPcLcfvt6-31j_zm1_ef11c3eatBz7kG2UBaJSpJzD2WoLFpqlJVTd310nBBiKQa6CTrVlEqFUyvO9n3BTNeiMuD7HZpNty17OZAk92GcUNhZz2N9s-IG9d28A-2AFCmMkng41Eg-PuF42w3qQWeJnLsl2gl1nWdhpkG-n-0qKGWJeqEfvgLvfNLcGkQe8qUNYDZ5_50oNrgYwzcn-qWYPcO2uSg3TtoFSb63dNWT-xvyxLw-QDEFHIDhydJ_6n3_ph97d1wn16cJAtt0kdRgI-WELAF</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Li, Xin</creator><creator>Xu, Huai-long</creator><creator>Liu, Yong-xi</creator><creator>An, Na</creator><creator>Zhao, Si</creator><creator>Bao, Jin-ku</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QO</scope><scope>5PM</scope></search><sort><creationdate>20130501</creationdate><title>Autophagy modulation as a target for anticancer drug discovery</title><author>Li, Xin ; Xu, Huai-long ; Liu, Yong-xi ; An, Na ; Zhao, Si ; Bao, Jin-ku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-501b00006321aeef36053bb7627b9df18e4a33a2b0d1e5c2a00308f5d1ff4ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - 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Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta pharmacologica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xin</au><au>Xu, Huai-long</au><au>Liu, Yong-xi</au><au>An, Na</au><au>Zhao, Si</au><au>Bao, Jin-ku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autophagy modulation as a target for anticancer drug discovery</atitle><jtitle>Acta pharmacologica Sinica</jtitle><stitle>Acta Pharmacol Sin</stitle><addtitle>Acta Pharmacologica Sinica</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>34</volume><issue>5</issue><spage>612</spage><epage>624</epage><pages>612-624</pages><issn>1671-4083</issn><eissn>1745-7254</eissn><abstract>an evolutionarily conserved catabolic process involving the engulfment and degradation of non-essential or abnormal cel- lular organelles and proteins, is crucial for homeostatic maintenance in living cells. This highly regulated, multi-step process has been implicated in diverse diseases including cancer. Autophagy can function as either a promoter or a suppressor of cancer, which makes it a promising and challenging therapeutic target. Herein, we overview the regulatory mechanisms and dual roles of autophagy in cancer. We also describe some of the representative agents that exert their anticancer effects by regulating autophagy. Additionally, some emerging strategies aimed at modulating autophagy are discussed as having the potential for future anticancer drug discovery. In summary, these findings will provide valuable information to better utilize autophagy in the future development of anticancer thera- peutics that meet clinical requirements.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23564085</pmid><doi>10.1038/aps.2013.23</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta pharmacologica Sinica, 2013-05, Vol.34 (5), p.612-624 |
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| subjects | Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Autophagy - drug effects Biomedical and Life Sciences Biomedicine Drug Discovery - methods Humans Immunology Internal Medicine Medical Microbiology MicroRNAs - genetics Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Pharmacology/Toxicology Review Vaccine 代谢过程 体内平衡 制作 抗癌作用 抗癌药物 监管机制 自噬 药物发现 |
| title | Autophagy modulation as a target for anticancer drug discovery |
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