Why should autophagic flux be assessed
As autophagy is involved in cell growth, survival, development and death, impaired autophagic flux has been linked to a variety of human pathophysiological processes, including neurodegeneration, cancer, myopathy, cardiovascular and immune-mediated disorders. There is a growing need to identify and...
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| Veröffentlicht in: | Acta pharmacologica Sinica 2013-05, Vol.34 (5), p.595-599 |
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| container_title | Acta pharmacologica Sinica |
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| creator | Zhang, Xiao-jie Chen, Sheng Huang, Kai-xing Le, Wei-dong |
| description | As autophagy is involved in cell growth, survival, development and death, impaired autophagic flux has been linked to a variety of human pathophysiological processes, including neurodegeneration, cancer, myopathy, cardiovascular and immune-mediated disorders. There is a growing need to identify and quantify the status of autophagic flux in different pathological conditions. Given that autophagy is a highly dynamic and complex process that is regulated at multiple steps, it is often assessed accurately. This perspective review article will focus on the autophagic flux defects in different human disorders and update the current methods of monitoring autophagic flux. This knowledge is essential for developing autophagy-related therapeutics for treating the diseases. |
| doi_str_mv | 10.1038/aps.2012.184 |
| format | Article |
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| ispartof | Acta pharmacologica Sinica, 2013-05, Vol.34 (5), p.595-599 |
| issn | 1671-4083 1745-7254 |
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| source | MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Autophagy Biomedical and Life Sciences Biomedicine Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Humans Immune System Diseases - metabolism Immune System Diseases - pathology Immunology Internal Medicine Medical Microbiology Muscular Diseases - metabolism Muscular Diseases - pathology Neoplasms - metabolism Neoplasms - pathology Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology perspective Pharmacology/Toxicology Vaccine 人类疾病 心血管疾病 生理过程 神经退行性疾病 细胞生长 自噬 评估 通量 |
| title | Why should autophagic flux be assessed |
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