Cytomegalovirus pp65 limits dissemination but is dispensable for persistence

The most abundantly produced virion protein in human cytomegalovirus (HCMV) is the immunodominant phosphoprotein 65 (pp65), which is frequently included in CMV vaccines. Although it is nonessential for in vitro CMV growth, pp65 displays immunomodulatory functions that support a potential role in pri...

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Veröffentlicht in:	The Journal of clinical investigation 2014-05, Vol.124 (5), p.1928-1944
Hauptverfasser:	Malouli, Daniel, Hansen, Scott G, Nakayasu, Ernesto S, Marshall, Emily E, Hughes, Colette M, Ventura, Abigail B, Gilbride, Roxanne M, Lewis, Matthew S, Xu, Guangwu, Kreklywich, Craig, Whizin, Nathan, Fischer, Miranda, Legasse, Alfred W, Viswanathan, Kasinath, Siess, Don, Camp, 2nd, David G, Axthelm, Michael K, Kahl, Christoph, DeFilippis, Victor R, Smith, Richard D, Streblow, Daniel N, Picker, Louis J, Früh, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation - immunology Biomedical research Cell Line Cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus - immunology Cytomegalovirus Infections - genetics Cytomegalovirus Infections - immunology Cytomegalovirus Infections - pathology Cytomegalovirus Vaccines - genetics Cytomegalovirus Vaccines - immunology Environmental Molecular Sciences Laboratory Gene Deletion Genetic aspects Human cytomegalovirus Humans Immune response Infections Lymphocytes Macaca mulatta Medical research Medicine, Experimental Mice Monkeys & apes Phosphoproteins - genetics Phosphoproteins - immunology Properties Proteins T-Lymphocytes - immunology T-Lymphocytes - pathology Vaccination Vaccines Viral Matrix Proteins - genetics Viral Matrix Proteins - immunology Viral proteins
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