Rosiglitazone protects neuroblastoma cells against advanced glycation end products-induced injury

Aim： To investigate the protective effects of rosiglitazone （RGZ） against the neuronal toxicity induced by advanced glycation end products （AGEs） and the underlying mechanisms. Methods： Neuroblastoma cell line SH-SYSY was used. Cell viability and apoptosis were assessed using MTT assay and flow cyto...

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Veröffentlicht in:	Acta pharmacologica Sinica 2011-08, Vol.32 (8), p.991-998
Hauptverfasser:	Wang, Li, Yu, Chun-jiang, Liu, Wei, Cheng, Lu-yang, Zhang, Yi-na
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid precursor protein Apoptosis Bax protein beta -Amyloid beta -Site APP cleaving enzyme 1 Biomedical and Life Sciences Biomedicine Catalase Cell Line, Tumor Cell Survival - drug effects Flow cytometry Gene expression Glycation End Products, Advanced - antagonists & inhibitors Glycation End Products, Advanced - metabolism Humans Immunology Injuries Insulin Internal Medicine Medical Microbiology Neuroblastoma - pathology Neuroblastoma cells Neurodegenerative diseases Neurons - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology Neurotoxicity Original original-article Peroxisome proliferator-activated receptors Pharmacology/Toxicology Reactive oxygen species rosiglitazone Superoxide dismutase Thiazolidinediones - pharmacology Vaccine Western blotting 保护作用损伤晚期神经母细胞瘤糖化终产物罗格列酮超氧化物歧化酶
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