Bezafibrate enhances proliferation and differentiation of osteoblastic MC3T3-E1 cells via AMPK and eNOS activation

Aim： To investigate the effects of bezafibrate on the proliferation and differentiation of osteoblastic MC3T3-E1 cells, and to determine the signaling pathway underlying the effects. Methods： MC3T3-E1 cells, a mouse osteoblastic cell line, were used. Cell viability and proliferation were examined us...

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Veröffentlicht in:	Acta pharmacologica Sinica 2011-05, Vol.32 (5), p.591-600
Hauptverfasser:	Zhong, Xing, Xiu, Ling-ling, Wei, Guo-hong, Liu, Yuan-yuan, Su, Lei, Cao, Xiao-pei, Li, Yan-bing, Xiao, Hai-peng
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells AMP-Activated Protein Kinases - metabolism AMPK Animals Bezafibrate Bezafibrate - administration & dosage Bezafibrate - pharmacology Biomedical and Life Sciences Biomedicine Bone morphogenetic protein 2 Cell Differentiation - drug effects Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Collagen (type I) Colorimetry Differentiation Dose-Response Relationship, Drug Drugs eNOS Gene expression Gene Expression Regulation - drug effects Immunology Internal Medicine Medical Microbiology Mice Mineralization mRNA表达 NG-Nitroarginine methyl ester Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Original original-article Osteoblastogenesis Osteoblasts Osteoblasts - drug effects Osteoblasts - metabolism Osteocalcin Osteogenesis Pharmacology/Toxicology Phosphorylation Phosphorylation - drug effects Polymerase chain reaction PPAR-beta - metabolism Signal transduction Time Factors Vaccine Western blotting 分化成骨细胞碱性磷酸酶细胞增殖苯扎贝特
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