$Long-term effects of alendronate on fracture healing and bone remodeling of femoral shaft in ovariectomized rats$

Long-term effects of alendronate on fracture healing and bone remodeling of femoral shaft in ovariectomized rats

Aim： To investigate the long-term effects of alendronate （AIn）, a widely used oral bisphosphonate, on fracture healing and bone remod- eling in ovariectomized rats. Methods： Adult female SD rats underwent ovariectomy, and then bilateral femoral osteotomy at 12 weeks post-ovariectomy. From d 2 post-o...

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Veröffentlicht in:	Acta pharmacologica Sinica 2013-03, Vol.34 (3), p.387-392
Hauptverfasser:	Fu, Ling-jie, Tang, Ting-ting, Hao, Yong-qiang, Dai, Ke-rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Alendronate - administration & dosage Alendronate - therapeutic use Animals Biomedical and Life Sciences Biomedicine Bone Density Conservation Agents - administration & dosage Bone Density Conservation Agents - therapeutic use Bone Remodeling - drug effects Disease Models, Animal Drug Administration Schedule Female Femoral Fractures - drug therapy Femoral Fractures - metabolism Femoral Fractures - pathology Femur - injuries Femur - metabolism Femur - pathology Fracture Healing - drug effects Immunology Internal Medicine Medical Microbiology Original original-article Ovariectomy Pharmacology/Toxicology Rats Rats, Sprague-Dawley Time Factors Vaccine 卵巢切除术去卵巢大鼠愈伤组织生理盐水股骨阿仑膦酸钠骨折愈合骨重建
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