C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population
Aim： The inflammatory marker C-reactive protein （CRP） has been strongly correlated with the risk of cardiovascular disease. Some single-nucleotide polymorphisms （SNPs） have been reported to be associated with serum CRP levels. In this study, we assessed the genetic association between SNPs within th...
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| Veröffentlicht in: | Acta pharmacologica Sinica 2009-03, Vol.30 (3), p.291-298 |
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| creator | Wang, Qi Ding, Hu Tang, Jia-rong Zhang, Lan Xu, Yu-jun Yan, Jiang-tao Wang, Wei Hui, Ru-tai Wang, Cong-yi Wang, Dao-wen |
| description | Aim： The inflammatory marker C-reactive protein （CRP） has been strongly correlated with the risk of cardiovascular disease. Some single-nucleotide polymorphisms （SNPs） have been reported to be associated with serum CRP levels. In this study, we assessed the genetic association between SNPs within the CRP gene and ischemic and hemorrhagic stroke in the Han Chinese population.
Methods： This study comprises 564 ischemic stroke patients, 220 hemorrhagic stroke patients and 564 controls from the ethnic Han Chinese population in Wuhan. Four CRP SNPs, -757A〉G （rs3093059）, -717A〉G （rs2794521）, -286C〉T〉A （rs3091244） and ＋2147C〉T （rs1205）, were genotyped from patients using TaqMan assays.
Results： The A allele frequency for the -717A〉G polymorphism was significant higher in controls than in ischemic stroke patients （P=0.037）, after adjustment for traditional risk factors （odds ratio 0.28; 95% CI 0.12-0.65; P=0.003）, suggesting a protective effect for this allele against ischemic stroke. Haplotype analysis showed that the H3 （G-C-C） haplotype conferred a significantly increased risk of ischemic stroke （odds ratio 1.052, 95% CI 1.001-1.106： P=0.047）. Neither CRP genotypes nor haplotypes showed an association with hemorrhagic stroke. However, the frequency for haplotype H5 （A-T-C） was significantly higher in ischemic stroke than hemorrhagic stroke patients （P=0.0003）.
Conclusions： These data suggest that the CRP gene -717A allele confers a protective effect against ischemic stroke. Furthermore, the H3 haplotype （G-C-C） is an independent risk marker for ischemic stroke, whereas the H5 haplotype （A-T-C） can be used as a prognostic marker of hemorrhagic stroke. |
| doi_str_mv | 10.1038/aps.2009.14 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4002404</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>29669673</cqvip_id><sourcerecordid>1730259521</sourcerecordid><originalsourceid>FETCH-LOGICAL-c502t-8db18309dd937508c03dd401a954a7845ee59f5e5c8bf7e34a405854a57296933</originalsourceid><addsrcrecordid>eNp9ks2L1DAYxoso7rp68i7Fgx60Y77bXBZkUFdY8KLnkKZvp9ltk26SLszZf9zUGRwV8ZSQ55fn_SyK5xhtMKLNOz3HDUFIbjB7UJzjmvGqJpw9zHdR44qhhp4VT2K8QYgSiuXj4gxLIgjn5Lz4vq0CaJPsPZRz8AmsK2c_7icf5sHGKZbadeUOHCRryrhEA3OyrR1t2pfJlzaaAaZVSsHfwk86P_gQBr07PWfXNEC5HayDCOWVXqPMy6iT9e5p8ajXY4Rnx_Oi-Pbxw9ftVXX95dPn7fvrynBEUtV0LW4okl0nac1RYxDtOoawlpzpumEcgMueAzdN29dAmWaIN1njNZFCUnpRXB5856WdoDPgUtCjmoOddNgrr636U3F2UDt_rxhChCGWDV4fDYK_WyAmNeX6YRy1A79EVTOBRR7JSr76LymEbKSgPIMv_wJv_BJcboMimOaBISEy9OYAmeBjDND_yhkjte6Ayjug1h1QeI394vcyT-xx6Bl4ewBiltwOwinmv_2OKZrBu91d_qFabW57O4LKjRVS1JT-AOqwyXY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213032066</pqid></control><display><type>article</type><title>C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Wang, Qi ; Ding, Hu ; Tang, Jia-rong ; Zhang, Lan ; Xu, Yu-jun ; Yan, Jiang-tao ; Wang, Wei ; Hui, Ru-tai ; Wang, Cong-yi ; Wang, Dao-wen</creator><creatorcontrib>Wang, Qi ; Ding, Hu ; Tang, Jia-rong ; Zhang, Lan ; Xu, Yu-jun ; Yan, Jiang-tao ; Wang, Wei ; Hui, Ru-tai ; Wang, Cong-yi ; Wang, Dao-wen</creatorcontrib><description>Aim： The inflammatory marker C-reactive protein （CRP） has been strongly correlated with the risk of cardiovascular disease. Some single-nucleotide polymorphisms （SNPs） have been reported to be associated with serum CRP levels. In this study, we assessed the genetic association between SNPs within the CRP gene and ischemic and hemorrhagic stroke in the Han Chinese population.
Methods： This study comprises 564 ischemic stroke patients, 220 hemorrhagic stroke patients and 564 controls from the ethnic Han Chinese population in Wuhan. Four CRP SNPs, -757A〉G （rs3093059）, -717A〉G （rs2794521）, -286C〉T〉A （rs3091244） and ＋2147C〉T （rs1205）, were genotyped from patients using TaqMan assays.
Results： The A allele frequency for the -717A〉G polymorphism was significant higher in controls than in ischemic stroke patients （P=0.037）, after adjustment for traditional risk factors （odds ratio 0.28; 95% CI 0.12-0.65; P=0.003）, suggesting a protective effect for this allele against ischemic stroke. Haplotype analysis showed that the H3 （G-C-C） haplotype conferred a significantly increased risk of ischemic stroke （odds ratio 1.052, 95% CI 1.001-1.106： P=0.047）. Neither CRP genotypes nor haplotypes showed an association with hemorrhagic stroke. However, the frequency for haplotype H5 （A-T-C） was significantly higher in ischemic stroke than hemorrhagic stroke patients （P=0.0003）.
Conclusions： These data suggest that the CRP gene -717A allele confers a protective effect against ischemic stroke. Furthermore, the H3 haplotype （G-C-C） is an independent risk marker for ischemic stroke, whereas the H5 haplotype （A-T-C） can be used as a prognostic marker of hemorrhagic stroke.</description><identifier>ISSN: 1671-4083</identifier><identifier>EISSN: 1745-7254</identifier><identifier>DOI: 10.1038/aps.2009.14</identifier><identifier>PMID: 19262552</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Alleles ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Brain Ischemia - ethnology ; Brain Ischemia - genetics ; C-Reactive Protein - genetics ; Cerebral Hemorrhage - ethnology ; Cerebral Hemorrhage - genetics ; China ; C反应蛋白 ; Female ; Genetic Predisposition to Disease - ethnology ; Genotype ; Haplotypes ; Humans ; Immunology ; Internal Medicine ; Male ; Medical Microbiology ; Middle Aged ; Odds Ratio ; Original ; original-article ; Pharmacology/Toxicology ; Polymorphism, Single Nucleotide ; Risk Factors ; Stroke - ethnology ; Stroke - genetics ; Vaccine ; 出血性中风 ; 单核苷酸多态性 ; 基因多态性 ; 汉族人群 ; 等位基因频率 ; 缺血性中风 ; 遗传易感性</subject><ispartof>Acta pharmacologica Sinica, 2009-03, Vol.30 (3), p.291-298</ispartof><rights>CPS and SIMM 2009</rights><rights>Copyright Nature Publishing Group Mar 2009</rights><rights>Copyright © 2009 CPS and SIMM 2009 CPS and SIMM</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-8db18309dd937508c03dd401a954a7845ee59f5e5c8bf7e34a405854a57296933</citedby><cites>FETCH-LOGICAL-c502t-8db18309dd937508c03dd401a954a7845ee59f5e5c8bf7e34a405854a57296933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/95561A/95561A.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002404/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002404/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19262552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Ding, Hu</creatorcontrib><creatorcontrib>Tang, Jia-rong</creatorcontrib><creatorcontrib>Zhang, Lan</creatorcontrib><creatorcontrib>Xu, Yu-jun</creatorcontrib><creatorcontrib>Yan, Jiang-tao</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Hui, Ru-tai</creatorcontrib><creatorcontrib>Wang, Cong-yi</creatorcontrib><creatorcontrib>Wang, Dao-wen</creatorcontrib><title>C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population</title><title>Acta pharmacologica Sinica</title><addtitle>Acta Pharmacol Sin</addtitle><addtitle>Acta Pharmacologica Sinica</addtitle><description>Aim： The inflammatory marker C-reactive protein （CRP） has been strongly correlated with the risk of cardiovascular disease. Some single-nucleotide polymorphisms （SNPs） have been reported to be associated with serum CRP levels. In this study, we assessed the genetic association between SNPs within the CRP gene and ischemic and hemorrhagic stroke in the Han Chinese population.
Methods： This study comprises 564 ischemic stroke patients, 220 hemorrhagic stroke patients and 564 controls from the ethnic Han Chinese population in Wuhan. Four CRP SNPs, -757A〉G （rs3093059）, -717A〉G （rs2794521）, -286C〉T〉A （rs3091244） and ＋2147C〉T （rs1205）, were genotyped from patients using TaqMan assays.
Results： The A allele frequency for the -717A〉G polymorphism was significant higher in controls than in ischemic stroke patients （P=0.037）, after adjustment for traditional risk factors （odds ratio 0.28; 95% CI 0.12-0.65; P=0.003）, suggesting a protective effect for this allele against ischemic stroke. Haplotype analysis showed that the H3 （G-C-C） haplotype conferred a significantly increased risk of ischemic stroke （odds ratio 1.052, 95% CI 1.001-1.106： P=0.047）. Neither CRP genotypes nor haplotypes showed an association with hemorrhagic stroke. However, the frequency for haplotype H5 （A-T-C） was significantly higher in ischemic stroke than hemorrhagic stroke patients （P=0.0003）.
Conclusions： These data suggest that the CRP gene -717A allele confers a protective effect against ischemic stroke. Furthermore, the H3 haplotype （G-C-C） is an independent risk marker for ischemic stroke, whereas the H5 haplotype （A-T-C） can be used as a prognostic marker of hemorrhagic stroke.</description><subject>Alleles</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain Ischemia - ethnology</subject><subject>Brain Ischemia - genetics</subject><subject>C-Reactive Protein - genetics</subject><subject>Cerebral Hemorrhage - ethnology</subject><subject>Cerebral Hemorrhage - genetics</subject><subject>China</subject><subject>C反应蛋白</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - ethnology</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Original</subject><subject>original-article</subject><subject>Pharmacology/Toxicology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><subject>Stroke - ethnology</subject><subject>Stroke - genetics</subject><subject>Vaccine</subject><subject>出血性中风</subject><subject>单核苷酸多态性</subject><subject>基因多态性</subject><subject>汉族人群</subject><subject>等位基因频率</subject><subject>缺血性中风</subject><subject>遗传易感性</subject><issn>1671-4083</issn><issn>1745-7254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9ks2L1DAYxoso7rp68i7Fgx60Y77bXBZkUFdY8KLnkKZvp9ltk26SLszZf9zUGRwV8ZSQ55fn_SyK5xhtMKLNOz3HDUFIbjB7UJzjmvGqJpw9zHdR44qhhp4VT2K8QYgSiuXj4gxLIgjn5Lz4vq0CaJPsPZRz8AmsK2c_7icf5sHGKZbadeUOHCRryrhEA3OyrR1t2pfJlzaaAaZVSsHfwk86P_gQBr07PWfXNEC5HayDCOWVXqPMy6iT9e5p8ajXY4Rnx_Oi-Pbxw9ftVXX95dPn7fvrynBEUtV0LW4okl0nac1RYxDtOoawlpzpumEcgMueAzdN29dAmWaIN1njNZFCUnpRXB5856WdoDPgUtCjmoOddNgrr636U3F2UDt_rxhChCGWDV4fDYK_WyAmNeX6YRy1A79EVTOBRR7JSr76LymEbKSgPIMv_wJv_BJcboMimOaBISEy9OYAmeBjDND_yhkjte6Ayjug1h1QeI394vcyT-xx6Bl4ewBiltwOwinmv_2OKZrBu91d_qFabW57O4LKjRVS1JT-AOqwyXY</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Wang, Qi</creator><creator>Ding, Hu</creator><creator>Tang, Jia-rong</creator><creator>Zhang, Lan</creator><creator>Xu, Yu-jun</creator><creator>Yan, Jiang-tao</creator><creator>Wang, Wei</creator><creator>Hui, Ru-tai</creator><creator>Wang, Cong-yi</creator><creator>Wang, Dao-wen</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090301</creationdate><title>C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population</title><author>Wang, Qi ; Ding, Hu ; Tang, Jia-rong ; Zhang, Lan ; Xu, Yu-jun ; Yan, Jiang-tao ; Wang, Wei ; Hui, Ru-tai ; Wang, Cong-yi ; Wang, Dao-wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-8db18309dd937508c03dd401a954a7845ee59f5e5c8bf7e34a405854a57296933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Alleles</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain Ischemia - ethnology</topic><topic>Brain Ischemia - genetics</topic><topic>C-Reactive Protein - genetics</topic><topic>Cerebral Hemorrhage - ethnology</topic><topic>Cerebral Hemorrhage - genetics</topic><topic>China</topic><topic>C反应蛋白</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - ethnology</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Immunology</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Original</topic><topic>original-article</topic><topic>Pharmacology/Toxicology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><topic>Stroke - ethnology</topic><topic>Stroke - genetics</topic><topic>Vaccine</topic><topic>出血性中风</topic><topic>单核苷酸多态性</topic><topic>基因多态性</topic><topic>汉族人群</topic><topic>等位基因频率</topic><topic>缺血性中风</topic><topic>遗传易感性</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Ding, Hu</creatorcontrib><creatorcontrib>Tang, Jia-rong</creatorcontrib><creatorcontrib>Zhang, Lan</creatorcontrib><creatorcontrib>Xu, Yu-jun</creatorcontrib><creatorcontrib>Yan, Jiang-tao</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Hui, Ru-tai</creatorcontrib><creatorcontrib>Wang, Cong-yi</creatorcontrib><creatorcontrib>Wang, Dao-wen</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta pharmacologica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Qi</au><au>Ding, Hu</au><au>Tang, Jia-rong</au><au>Zhang, Lan</au><au>Xu, Yu-jun</au><au>Yan, Jiang-tao</au><au>Wang, Wei</au><au>Hui, Ru-tai</au><au>Wang, Cong-yi</au><au>Wang, Dao-wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population</atitle><jtitle>Acta pharmacologica Sinica</jtitle><stitle>Acta Pharmacol Sin</stitle><addtitle>Acta Pharmacologica Sinica</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>30</volume><issue>3</issue><spage>291</spage><epage>298</epage><pages>291-298</pages><issn>1671-4083</issn><eissn>1745-7254</eissn><abstract>Aim： The inflammatory marker C-reactive protein （CRP） has been strongly correlated with the risk of cardiovascular disease. Some single-nucleotide polymorphisms （SNPs） have been reported to be associated with serum CRP levels. In this study, we assessed the genetic association between SNPs within the CRP gene and ischemic and hemorrhagic stroke in the Han Chinese population.
Methods： This study comprises 564 ischemic stroke patients, 220 hemorrhagic stroke patients and 564 controls from the ethnic Han Chinese population in Wuhan. Four CRP SNPs, -757A〉G （rs3093059）, -717A〉G （rs2794521）, -286C〉T〉A （rs3091244） and ＋2147C〉T （rs1205）, were genotyped from patients using TaqMan assays.
Results： The A allele frequency for the -717A〉G polymorphism was significant higher in controls than in ischemic stroke patients （P=0.037）, after adjustment for traditional risk factors （odds ratio 0.28; 95% CI 0.12-0.65; P=0.003）, suggesting a protective effect for this allele against ischemic stroke. Haplotype analysis showed that the H3 （G-C-C） haplotype conferred a significantly increased risk of ischemic stroke （odds ratio 1.052, 95% CI 1.001-1.106： P=0.047）. Neither CRP genotypes nor haplotypes showed an association with hemorrhagic stroke. However, the frequency for haplotype H5 （A-T-C） was significantly higher in ischemic stroke than hemorrhagic stroke patients （P=0.0003）.
Conclusions： These data suggest that the CRP gene -717A allele confers a protective effect against ischemic stroke. Furthermore, the H3 haplotype （G-C-C） is an independent risk marker for ischemic stroke, whereas the H5 haplotype （A-T-C） can be used as a prognostic marker of hemorrhagic stroke.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19262552</pmid><doi>10.1038/aps.2009.14</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alleles Biomarkers Biomedical and Life Sciences Biomedicine Brain Ischemia - ethnology Brain Ischemia - genetics C-Reactive Protein - genetics Cerebral Hemorrhage - ethnology Cerebral Hemorrhage - genetics China C反应蛋白 Female Genetic Predisposition to Disease - ethnology Genotype Haplotypes Humans Immunology Internal Medicine Male Medical Microbiology Middle Aged Odds Ratio Original original-article Pharmacology/Toxicology Polymorphism, Single Nucleotide Risk Factors Stroke - ethnology Stroke - genetics Vaccine 出血性中风 单核苷酸多态性 基因多态性 汉族人群 等位基因频率 缺血性中风 遗传易感性 |
| title | C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population |
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