Cathelicidins in inflammation and tissue repair： Potential therapeutic applications for gastrointestinal disorders
Cathelicidins, a family of host defense peptides, are highly expressed during infection, inflammation and wound healing. These peptides not only have broad-spectrum antimicrobial activities, but also modulate inflammation by altering cytokine response and chemoattraction of inflammatory cells in dis...
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| Veröffentlicht in: | Acta pharmacologica Sinica 2010-09, Vol.31 (9), p.1118-1122 |
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| creator | Wu, William Ka Kei Wong, Clover Ching Man Li, Zhi Jie Zhang, Lin Ren, Shun Xiang Cho, Chi Hin |
| description | Cathelicidins, a family of host defense peptides, are highly expressed during infection, inflammation and wound healing. These peptides not only have broad-spectrum antimicrobial activities, but also modulate inflammation by altering cytokine response and chemoattraction of inflammatory cells in diseased tissues. In this connection, a mouse cathelicidin has been demonstrated to prevent inflammation in the colon through enhancing mucus production and reducing production of pro-inflammatory cytokines. In addition, cathelicidins promote wound healing through stimulation of re-epithelialization and angiogenesis at injured tissues. In an animal model of gastric ulceration, the rat cathelicidin promotes ulcer healing by inducing proliferation of gastric epithelial cells both in vitro and in vivo. In conclusion, cathelicidins represent an important group of effector molecules in the innate immune system that operates a complex integration of inflammation and tissue repair in the gastrointestinal mucosa and other organs. |
| doi_str_mv | 10.1038/aps.2010.117 |
| format | Article |
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These peptides not only have broad-spectrum antimicrobial activities, but also modulate inflammation by altering cytokine response and chemoattraction of inflammatory cells in diseased tissues. In this connection, a mouse cathelicidin has been demonstrated to prevent inflammation in the colon through enhancing mucus production and reducing production of pro-inflammatory cytokines. In addition, cathelicidins promote wound healing through stimulation of re-epithelialization and angiogenesis at injured tissues. In an animal model of gastric ulceration, the rat cathelicidin promotes ulcer healing by inducing proliferation of gastric epithelial cells both in vitro and in vivo. In conclusion, cathelicidins represent an important group of effector molecules in the innate immune system that operates a complex integration of inflammation and tissue repair in the gastrointestinal mucosa and other organs.</description><identifier>ISSN: 1671-4083</identifier><identifier>EISSN: 1745-7254</identifier><identifier>DOI: 10.1038/aps.2010.117</identifier><identifier>PMID: 20676121</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Cathelicidins ; Cathelicidins - immunology ; Cathelicidins - therapeutic use ; Gastrointestinal Diseases - drug therapy ; Gastrointestinal Diseases - immunology ; Humans ; Immunology ; Inflammation - drug therapy ; Inflammation - immunology ; Internal Medicine ; Medical Microbiology ; Pharmacology/Toxicology ; Review ; Vaccine ; Wound Healing - drug effects ; 伤口愈合 ; 组织修复 ; 胃肠道疾病</subject><ispartof>Acta pharmacologica Sinica, 2010-09, Vol.31 (9), p.1118-1122</ispartof><rights>CPS and SIMM 2010</rights><rights>Copyright Nature Publishing Group Sep 2010</rights><rights>Copyright © 2010 CPS and SIMM 2010 CPS and SIMM</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-60ccf9bd48ec4d0080cf137daac55c2d61f92a168bcc2c471c13e1808ec5bf843</citedby><cites>FETCH-LOGICAL-c507t-60ccf9bd48ec4d0080cf137daac55c2d61f92a168bcc2c471c13e1808ec5bf843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/95561A/95561A.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002301/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002301/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20676121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, William Ka Kei</creatorcontrib><creatorcontrib>Wong, Clover Ching Man</creatorcontrib><creatorcontrib>Li, Zhi Jie</creatorcontrib><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Ren, Shun Xiang</creatorcontrib><creatorcontrib>Cho, Chi Hin</creatorcontrib><title>Cathelicidins in inflammation and tissue repair： Potential therapeutic applications for gastrointestinal disorders</title><title>Acta pharmacologica Sinica</title><addtitle>Acta Pharmacol Sin</addtitle><addtitle>Acta Pharmacologica Sinica</addtitle><description>Cathelicidins, a family of host defense peptides, are highly expressed during infection, inflammation and wound healing. These peptides not only have broad-spectrum antimicrobial activities, but also modulate inflammation by altering cytokine response and chemoattraction of inflammatory cells in diseased tissues. In this connection, a mouse cathelicidin has been demonstrated to prevent inflammation in the colon through enhancing mucus production and reducing production of pro-inflammatory cytokines. In addition, cathelicidins promote wound healing through stimulation of re-epithelialization and angiogenesis at injured tissues. In an animal model of gastric ulceration, the rat cathelicidin promotes ulcer healing by inducing proliferation of gastric epithelial cells both in vitro and in vivo. In conclusion, cathelicidins represent an important group of effector molecules in the innate immune system that operates a complex integration of inflammation and tissue repair in the gastrointestinal mucosa and other organs.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cathelicidins</subject><subject>Cathelicidins - immunology</subject><subject>Cathelicidins - therapeutic use</subject><subject>Gastrointestinal Diseases - drug therapy</subject><subject>Gastrointestinal Diseases - immunology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - immunology</subject><subject>Internal Medicine</subject><subject>Medical Microbiology</subject><subject>Pharmacology/Toxicology</subject><subject>Review</subject><subject>Vaccine</subject><subject>Wound Healing - drug effects</subject><subject>伤口愈合</subject><subject>组织修复</subject><subject>胃肠道疾病</subject><issn>1671-4083</issn><issn>1745-7254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkcuKFTEQhhtRnHF051oaN27ssXLpJL0RhoM3GNCFrkM6nT4nY3fSk6QFX8Vn8Z18Bet4juMFRBJIhfrqT1X-qnpI4JwAU8_Mks8p7G9E3qpOieRtI2nLb2MsJGk4KHZS3cv5CoBRRrq71QkFIQWh5LQqG1N2bvLWDz7k2gfc42Tm2RQfQ23CUBef8-rq5Bbj07evX-p3sbhQvJlqLE1mcWvxtjbLgjI_ynI9xlRvTS4p-lBcLj4gPfgc0-BSvl_dGc2U3YPjeVZ9ePni_eZ1c_n21ZvNxWVjW5ClEWDt2PUDV87yAUCBHQmTgzG2bS0dBBk7aohQvbXUckksYY4oQLztR8XZWfX8oLus_ewGi10nM-kl-dmkzzoar__MBL_T2_hJcwDKgKDAk6NAitcrzqFnn62bJhNcXLNWUraqEwL-S8qWA-GdUkg-_ou8imvC_0GId1xwIhlCTw-QTTHn5Mabpgnove0abdd72zXajvij3we9gX_6jEBzADKmwtalX4_-Q_DYpN3FsL3GEt0b-3H0k9OsxUWFYN8BNPzIGA</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Wu, William Ka Kei</creator><creator>Wong, Clover Ching Man</creator><creator>Li, Zhi Jie</creator><creator>Zhang, Lin</creator><creator>Ren, Shun Xiang</creator><creator>Cho, Chi Hin</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20100901</creationdate><title>Cathelicidins in inflammation and tissue repair： Potential therapeutic applications for gastrointestinal disorders</title><author>Wu, William Ka Kei ; Wong, Clover Ching Man ; Li, Zhi Jie ; Zhang, Lin ; Ren, Shun Xiang ; Cho, Chi Hin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-60ccf9bd48ec4d0080cf137daac55c2d61f92a168bcc2c471c13e1808ec5bf843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cathelicidins</topic><topic>Cathelicidins - 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Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta pharmacologica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, William Ka Kei</au><au>Wong, Clover Ching Man</au><au>Li, Zhi Jie</au><au>Zhang, Lin</au><au>Ren, Shun Xiang</au><au>Cho, Chi Hin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cathelicidins in inflammation and tissue repair： Potential therapeutic applications for gastrointestinal disorders</atitle><jtitle>Acta pharmacologica Sinica</jtitle><stitle>Acta Pharmacol Sin</stitle><addtitle>Acta Pharmacologica Sinica</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>31</volume><issue>9</issue><spage>1118</spage><epage>1122</epage><pages>1118-1122</pages><issn>1671-4083</issn><eissn>1745-7254</eissn><abstract>Cathelicidins, a family of host defense peptides, are highly expressed during infection, inflammation and wound healing. These peptides not only have broad-spectrum antimicrobial activities, but also modulate inflammation by altering cytokine response and chemoattraction of inflammatory cells in diseased tissues. In this connection, a mouse cathelicidin has been demonstrated to prevent inflammation in the colon through enhancing mucus production and reducing production of pro-inflammatory cytokines. In addition, cathelicidins promote wound healing through stimulation of re-epithelialization and angiogenesis at injured tissues. In an animal model of gastric ulceration, the rat cathelicidin promotes ulcer healing by inducing proliferation of gastric epithelial cells both in vitro and in vivo. In conclusion, cathelicidins represent an important group of effector molecules in the innate immune system that operates a complex integration of inflammation and tissue repair in the gastrointestinal mucosa and other organs.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20676121</pmid><doi>10.1038/aps.2010.117</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biomedical and Life Sciences Biomedicine Cathelicidins Cathelicidins - immunology Cathelicidins - therapeutic use Gastrointestinal Diseases - drug therapy Gastrointestinal Diseases - immunology Humans Immunology Inflammation - drug therapy Inflammation - immunology Internal Medicine Medical Microbiology Pharmacology/Toxicology Review Vaccine Wound Healing - drug effects 伤口愈合 组织修复 胃肠道疾病 |
| title | Cathelicidins in inflammation and tissue repair： Potential therapeutic applications for gastrointestinal disorders |
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