Vitamin D Inhibits COX-2 Expression and Inflammatory Response by Targeting Thioesterase Superfamily Member 4

Inadequate vitamin D status has been linked to increased risk of type 2 diabetes and cardiovascular disease. Inducible cyclooxygenase (COX) isoform COX-2 has been involved in the pathogenesis of such chronic inflammatory diseases. We found that the active form of vitamin D, 1,25(OH)2D produces dose-...

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Veröffentlicht in:	The Journal of biological chemistry 2014-04, Vol.289 (17), p.11681-11694
Hauptverfasser:	Wang, Qingsong, He, Yuhu, Shen, Yujun, Zhang, Qianqian, Chen, Di, Zuo, Caojian, Qin, Jing, Wang, Hui, Wang, Junwen, Yu, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Calcitriol - pharmacology Carrageenan - toxicity Cell Biology Cell Line Cyclooxygenase (COX) Pathway Cyclooxygenase 2 - genetics DNA Primers Enzyme-Linked Immunosorbent Assay Fatty Acids, Nonesterified - metabolism Gene Expression Regulation, Enzymologic - drug effects Humans Inflammation - chemically induced Inflammation - prevention & control Lipopolysaccharide (LPS) Macrophages Macrophages - drug effects Macrophages - enzymology Macrophages - metabolism MAP Kinase Signaling System - drug effects Mice Mice, Inbred C57BL Mice, Knockout NF-kappa B (NF-KB) Phosphorylation Prostaglandins - biosynthesis Reverse Transcriptase Polymerase Chain Reaction Thiolester Hydrolases - metabolism VDR Vitamin D
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