Chitosan oligosaccharides suppress LPS-induced IL-8 expression in human umbilical vein endothelial cells through blockade of p38 and Akt protein kinases

Aim： To investigate whether and how COS inhibited IL-8 production in LPS-induced human umbilical vein endothelial cells （HUVECs）. Methods： RT-PCR, enzyme-linked immunosorbent assays （ELISA） and Western blotting were used to study IL-8 expression and related signaling pathway. Wound healing migration...

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Veröffentlicht in:	Acta pharmacologica Sinica 2011-04, Vol.32 (4), p.478-486
Hauptverfasser:	Liu, Hong-tao, Huang, Pei, Ma, Pan, Liu, Qi-shun, Yu, Chao, Du, Yu-guang
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Base Sequence Biomedical and Life Sciences Biomedicine Cells, Cultured Chitosan - pharmacology DNA Primers Enzyme-Linked Immunosorbent Assay Humans Immunology Interleukin-8 - pharmacology Internal Medicine Lipopolysaccharides - pharmacology LPS Medical Microbiology Oligosaccharides - pharmacology Original original-article p38 Mitogen-Activated Protein Kinases - metabolism p38丝裂原活化蛋白激酶 Pharmacology/Toxicology Reverse Transcriptase Polymerase Chain Reaction Umbilical Veins - cytology Umbilical Veins - drug effects Umbilical Veins - enzymology Umbilical Veins - metabolism Vaccine Western印迹法人脐静脉内皮细胞封锁细胞表达诱导产生
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