Enhancement of antitumor immunity by low-dose total body irradiationis associated with selectively decreasing the proportion and number of T regulatorycells
Low-dose total body irradiation (LTBI) is used in the treatment of somecancers mainly for immune enhancement rather than cell killing. However, themechanism underlying LTBI remains unknown. In this study, by analyzing theimmune patterns of lymphocytes, we found that the percentage and absolutenumber...
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| Veröffentlicht in: | Cellular & molecular immunology 2010-03, Vol.7 (2), p.157-162 |
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| creator | Liu, Rongjun Xiong, Shudao Zhang, Lei Chu, Yiwei |
| description | Low-dose total body irradiation (LTBI) is used in the treatment of somecancers mainly for immune enhancement rather than cell killing. However, themechanism underlying LTBI remains unknown. In this study, by analyzing theimmune patterns of lymphocytes, we found that the percentage and absolutenumber of CD4
+
CD25
+
Foxp3
+
regulatory T cells are markedly decreased in naive mice following treatmentwith LTBI. On the contrary, the CD4
+
CD44
+
/CD8
+
CD44
+
effector-memory T cells are greatly increased. Importantly, naive mice treatedwith dendritic cell-gp100 tumor vaccines under LTBI induced an enhancementof antigen-specific proliferation and cytotoxicity as well as interferon-γ(IFN-γ) secretion against F10 melanoma tumor challenge, compared to treatmentwith either the tumor vaccine or LTBI alone. Consequently, the treatment resultedin a reduced tumor burden and prolonged mouse survival. Our data demonstratethat LTBI’s enhancement of antitumor immunity was mainly associatedwith selectively decreasing the proportion and number of T regulatory cells,implying the potential application of the combination of LTBI and a tumorvaccine in antitumor therapy. |
| doi_str_mv | 10.1038/cmi.2009.117 |
| format | Article |
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+
CD25
+
Foxp3
+
regulatory T cells are markedly decreased in naive mice following treatmentwith LTBI. On the contrary, the CD4
+
CD44
+
/CD8
+
CD44
+
effector-memory T cells are greatly increased. Importantly, naive mice treatedwith dendritic cell-gp100 tumor vaccines under LTBI induced an enhancementof antigen-specific proliferation and cytotoxicity as well as interferon-γ(IFN-γ) secretion against F10 melanoma tumor challenge, compared to treatmentwith either the tumor vaccine or LTBI alone. Consequently, the treatment resultedin a reduced tumor burden and prolonged mouse survival. Our data demonstratethat LTBI’s enhancement of antitumor immunity was mainly associatedwith selectively decreasing the proportion and number of T regulatory cells,implying the potential application of the combination of LTBI and a tumorvaccine in antitumor therapy.</description><identifier>ISSN: 1672-7681</identifier><identifier>EISSN: 2042-0226</identifier><identifier>DOI: 10.1038/cmi.2009.117</identifier><identifier>PMID: 20140010</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Antibodies ; Biomedical and Life Sciences ; Biomedicine ; Cancer vaccines ; CD25 antigen ; CD4 antigen ; CD44 antigen ; CD8 antigen ; Cytotoxicity ; Dendritic cells ; Effector cells ; Foxp3 protein ; Glycoprotein gp100 ; Immunity ; Immunological memory ; Immunology ; Immunoregulation ; Lymphocytes T ; Medical Microbiology ; Melanoma ; Memory cells ; Microbiology ; Radiation ; research-article ; Tumors ; Vaccine ; Vaccines ; γ-Interferon</subject><ispartof>Cellular & molecular immunology, 2010-03, Vol.7 (2), p.157-162</ispartof><rights>Chinese Society of Immunology and The University of Science and Technology 2010</rights><rights>Copyright Nature Publishing Group Mar 2010</rights><rights>Chinese Society of Immunology and The University of Science and Technology 2010.</rights><rights>Copyright © 2010 Chinese Society of Immunology and The University of Science and Technology 2010 Chinese Society of Immunology and The University of Science and Technology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3947-4301e3807e6057e89e428f6282f174a091c8d2c91eaf2b778b5dcd46311c51f93</citedby><cites>FETCH-LOGICAL-c3947-4301e3807e6057e89e428f6282f174a091c8d2c91eaf2b778b5dcd46311c51f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001896/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001896/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Liu, Rongjun</creatorcontrib><creatorcontrib>Xiong, Shudao</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Chu, Yiwei</creatorcontrib><title>Enhancement of antitumor immunity by low-dose total body irradiationis associated with selectively decreasing the proportion and number of T regulatorycells</title><title>Cellular & molecular immunology</title><addtitle>Cell Mol Immunol</addtitle><description>Low-dose total body irradiation (LTBI) is used in the treatment of somecancers mainly for immune enhancement rather than cell killing. However, themechanism underlying LTBI remains unknown. In this study, by analyzing theimmune patterns of lymphocytes, we found that the percentage and absolutenumber of CD4
+
CD25
+
Foxp3
+
regulatory T cells are markedly decreased in naive mice following treatmentwith LTBI. On the contrary, the CD4
+
CD44
+
/CD8
+
CD44
+
effector-memory T cells are greatly increased. Importantly, naive mice treatedwith dendritic cell-gp100 tumor vaccines under LTBI induced an enhancementof antigen-specific proliferation and cytotoxicity as well as interferon-γ(IFN-γ) secretion against F10 melanoma tumor challenge, compared to treatmentwith either the tumor vaccine or LTBI alone. Consequently, the treatment resultedin a reduced tumor burden and prolonged mouse survival. Our data demonstratethat LTBI’s enhancement of antitumor immunity was mainly associatedwith selectively decreasing the proportion and number of T regulatory cells,implying the potential application of the combination of LTBI and a tumorvaccine in antitumor therapy.</description><subject>Antibodies</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer vaccines</subject><subject>CD25 antigen</subject><subject>CD4 antigen</subject><subject>CD44 antigen</subject><subject>CD8 antigen</subject><subject>Cytotoxicity</subject><subject>Dendritic cells</subject><subject>Effector cells</subject><subject>Foxp3 protein</subject><subject>Glycoprotein gp100</subject><subject>Immunity</subject><subject>Immunological memory</subject><subject>Immunology</subject><subject>Immunoregulation</subject><subject>Lymphocytes T</subject><subject>Medical Microbiology</subject><subject>Melanoma</subject><subject>Memory cells</subject><subject>Microbiology</subject><subject>Radiation</subject><subject>research-article</subject><subject>Tumors</subject><subject>Vaccine</subject><subject>Vaccines</subject><subject>γ-Interferon</subject><issn>1672-7681</issn><issn>2042-0226</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9ksFqHSEUhqU0NLdpd30AoYtuOrfqOKOzKZSQNoFAN8laHD1zr2FGb9VJmHfpw9bhhtCGkpWIn9_xHH-EPlCypaSWX8zktoyQbkupeIU2jHBWEcba12hDW8Eq0Up6it6mdEdII7ngb9ApI5QTQskG_b7we-0NTOAzDgPWPrs8TyFiN02zd3nB_YLH8FDZkADnkPWI-2AX7GLU1unsgncJ65SCKTuw-MHlPU4wgsnuHsYFWzARdHJ-h_Me8CGGQ4jrvVLNYj9PPcS19g2OsJtHnUNcDIxjeodOBj0meP-4nqHb7xc355fV9c8fV-ffritTd1xUvCYUakkEtKQRIDvgTA4tk2yggmvSUSMtMx0FPbBeCNk31lje1pSahg5dfYa-Hr2HuZ_AmjKLqEd1iG7ScVFBO_XviXd7tQv3ah2i7Noi-PQoiOHXDCmryaW1Be0hzEmJhje8FowV8uMz8i7M0ZfuFBNt-c-Gi_YligrZiEZQvro-HykTQ0oRhqcXU6LWbKiSDbVmQ5VsFLw64qlgfgfxL-n_eXzkvc5zhCd5gVZmRf4AwkDIQg</recordid><startdate>201003</startdate><enddate>201003</enddate><creator>Liu, Rongjun</creator><creator>Xiong, Shudao</creator><creator>Zhang, Lei</creator><creator>Chu, Yiwei</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>201003</creationdate><title>Enhancement of antitumor immunity by low-dose total body irradiationis associated with selectively decreasing the proportion and number of T regulatorycells</title><author>Liu, Rongjun ; Xiong, Shudao ; Zhang, Lei ; Chu, Yiwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3947-4301e3807e6057e89e428f6282f174a091c8d2c91eaf2b778b5dcd46311c51f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antibodies</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer vaccines</topic><topic>CD25 antigen</topic><topic>CD4 antigen</topic><topic>CD44 antigen</topic><topic>CD8 antigen</topic><topic>Cytotoxicity</topic><topic>Dendritic cells</topic><topic>Effector cells</topic><topic>Foxp3 protein</topic><topic>Glycoprotein gp100</topic><topic>Immunity</topic><topic>Immunological memory</topic><topic>Immunology</topic><topic>Immunoregulation</topic><topic>Lymphocytes T</topic><topic>Medical Microbiology</topic><topic>Melanoma</topic><topic>Memory cells</topic><topic>Microbiology</topic><topic>Radiation</topic><topic>research-article</topic><topic>Tumors</topic><topic>Vaccine</topic><topic>Vaccines</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Rongjun</creatorcontrib><creatorcontrib>Xiong, Shudao</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Chu, Yiwei</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular & molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Rongjun</au><au>Xiong, Shudao</au><au>Zhang, Lei</au><au>Chu, Yiwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancement of antitumor immunity by low-dose total body irradiationis associated with selectively decreasing the proportion and number of T regulatorycells</atitle><jtitle>Cellular & molecular immunology</jtitle><stitle>Cell Mol Immunol</stitle><date>2010-03</date><risdate>2010</risdate><volume>7</volume><issue>2</issue><spage>157</spage><epage>162</epage><pages>157-162</pages><issn>1672-7681</issn><eissn>2042-0226</eissn><abstract>Low-dose total body irradiation (LTBI) is used in the treatment of somecancers mainly for immune enhancement rather than cell killing. However, themechanism underlying LTBI remains unknown. In this study, by analyzing theimmune patterns of lymphocytes, we found that the percentage and absolutenumber of CD4
+
CD25
+
Foxp3
+
regulatory T cells are markedly decreased in naive mice following treatmentwith LTBI. On the contrary, the CD4
+
CD44
+
/CD8
+
CD44
+
effector-memory T cells are greatly increased. Importantly, naive mice treatedwith dendritic cell-gp100 tumor vaccines under LTBI induced an enhancementof antigen-specific proliferation and cytotoxicity as well as interferon-γ(IFN-γ) secretion against F10 melanoma tumor challenge, compared to treatmentwith either the tumor vaccine or LTBI alone. Consequently, the treatment resultedin a reduced tumor burden and prolonged mouse survival. Our data demonstratethat LTBI’s enhancement of antitumor immunity was mainly associatedwith selectively decreasing the proportion and number of T regulatory cells,implying the potential application of the combination of LTBI and a tumorvaccine in antitumor therapy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20140010</pmid><doi>10.1038/cmi.2009.117</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cellular & molecular immunology, 2010-03, Vol.7 (2), p.157-162 |
| issn | 1672-7681 2042-0226 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4001896 |
| source | EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Antibodies Biomedical and Life Sciences Biomedicine Cancer vaccines CD25 antigen CD4 antigen CD44 antigen CD8 antigen Cytotoxicity Dendritic cells Effector cells Foxp3 protein Glycoprotein gp100 Immunity Immunological memory Immunology Immunoregulation Lymphocytes T Medical Microbiology Melanoma Memory cells Microbiology Radiation research-article Tumors Vaccine Vaccines γ-Interferon |
| title | Enhancement of antitumor immunity by low-dose total body irradiationis associated with selectively decreasing the proportion and number of T regulatorycells |
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