Increased expression of human T-cell immunoglobulin-and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus
Systemic lupus erythematosus （SLE） is a prototypic autoimmune disease. Innate and adaptive immunity cooperatively contribute to the development of SLE. Antigen-presenting cells （APCs） have been suggested to link innate and adaptive immunity. T-cell immunoglobulin- and mucin-domain-containing molecul...
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| Veröffentlicht in: | Cellular & molecular immunology 2010-03, Vol.7 (2), p.152-156 |
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| creator | Zhao, Peiqing Xu, Liyun Wang, Piming Liang, Xiaohong Qi, Jianni Liu, Peng Guo, Chun Zhang, Lining Ma, Chunhong Gao, Lifen |
| description | Systemic lupus erythematosus （SLE） is a prototypic autoimmune disease. Innate and adaptive immunity cooperatively contribute to the development of SLE. Antigen-presenting cells （APCs） have been suggested to link innate and adaptive immunity. T-cell immunoglobulin- and mucin-domain-containing molecule-4 （Tim-4; also known as Timd4）, expressed primarily on the surface of APCs, is a member of the TIM family, a recently described group of molecules that have received much attention as potential regulators of the immune system. In this study, we used quantitative real-time reverse transcription-polymerase chain reaction to examine the mRNA expression of Tim-4 in peripheral blood mononuclear cells （PBMCs） from SLE patients and further analyzed the correlation between the expression of Tim-4 and Tim- 1 （a potential l igand for Tim-4） in PB MCs and serum tumor necrosis factor （TNF）-a levels. The results showed that Tim-4 mRNA expression in PBMCs was significantly higher in SLE patients than in healthy controls, especially those patients in the active phase of disease. Moreover, Tim-4 mRNA levels were closely correlated with Tim- 1 mRNA levels in PBMCs and with serum TNF-a levels in SLE patients but not in the control group. Taken together, these results demonstrate that Tim-4 may be involved in the pathogenesis of SLE. |
| doi_str_mv | 10.1038/cmi.2009.118 |
| format | Article |
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Innate and adaptive immunity cooperatively contribute to the development of SLE. Antigen-presenting cells （APCs） have been suggested to link innate and adaptive immunity. T-cell immunoglobulin- and mucin-domain-containing molecule-4 （Tim-4; also known as Timd4）, expressed primarily on the surface of APCs, is a member of the TIM family, a recently described group of molecules that have received much attention as potential regulators of the immune system. In this study, we used quantitative real-time reverse transcription-polymerase chain reaction to examine the mRNA expression of Tim-4 in peripheral blood mononuclear cells （PBMCs） from SLE patients and further analyzed the correlation between the expression of Tim-4 and Tim- 1 （a potential l igand for Tim-4） in PB MCs and serum tumor necrosis factor （TNF）-a levels. The results showed that Tim-4 mRNA expression in PBMCs was significantly higher in SLE patients than in healthy controls, especially those patients in the active phase of disease. Moreover, Tim-4 mRNA levels were closely correlated with Tim- 1 mRNA levels in PBMCs and with serum TNF-a levels in SLE patients but not in the control group. Taken together, these results demonstrate that Tim-4 may be involved in the pathogenesis of SLE.</description><identifier>ISSN: 1672-7681</identifier><identifier>EISSN: 2042-0226</identifier><identifier>DOI: 10.1038/cmi.2009.118</identifier><identifier>PMID: 20140011</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adaptive immunity ; Adolescent ; Adult ; Antibodies ; Antigen-presenting cells ; Autoimmune diseases ; Biomedical and Life Sciences ; Biomedicine ; Child ; Female ; Gene expression ; Gene Expression Regulation ; Hepatitis A Virus Cellular Receptor 1 ; Humans ; Immune system ; Immunoglobulins ; Immunology ; Leukocytes (mononuclear) ; Leukocytes - immunology ; Lupus ; Lupus Erythematosus, Systemic - blood ; Lupus Erythematosus, Systemic - genetics ; Lupus Erythematosus, Systemic - immunology ; Lymphocytes T ; Male ; Medical Microbiology ; Membrane Glycoproteins - genetics ; Membrane Proteins - genetics ; Membrane Proteins - immunology ; Microbiology ; Middle Aged ; mRNA水平 ; Mucin ; Peripheral blood mononuclear cells ; Receptors, Virus - genetics ; research-article ; Reverse transcription ; RNA, Messenger - genetics ; Systemic lupus erythematosus ; Tumor Necrosis Factor-alpha - blood ; Tumor Necrosis Factor-alpha - immunology ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; T细胞 ; Vaccine ; Young Adult ; 免疫球蛋白 ; 外周血单个核细胞 ; 粘蛋白 ; 系统性红斑狼疮</subject><ispartof>Cellular & molecular immunology, 2010-03, Vol.7 (2), p.152-156</ispartof><rights>Chinese Society of Immunology and The University of Science and Technology 2010</rights><rights>Copyright Nature Publishing Group Mar 2010</rights><rights>Chinese Society of Immunology and The University of Science and Technology 2010.</rights><rights>Copyright © 2010 Chinese Society of Immunology and The University of Science and Technology 2010 Chinese Society of Immunology and The University of Science and Technology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-f22b9b6cf0fe1e4318a082fe3170892f00748f929918c64fe792f512c07b20463</citedby><cites>FETCH-LOGICAL-c561t-f22b9b6cf0fe1e4318a082fe3170892f00748f929918c64fe792f512c07b20463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/87787X/87787X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001890/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001890/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20140011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Peiqing</creatorcontrib><creatorcontrib>Xu, Liyun</creatorcontrib><creatorcontrib>Wang, Piming</creatorcontrib><creatorcontrib>Liang, Xiaohong</creatorcontrib><creatorcontrib>Qi, Jianni</creatorcontrib><creatorcontrib>Liu, Peng</creatorcontrib><creatorcontrib>Guo, Chun</creatorcontrib><creatorcontrib>Zhang, Lining</creatorcontrib><creatorcontrib>Ma, Chunhong</creatorcontrib><creatorcontrib>Gao, Lifen</creatorcontrib><title>Increased expression of human T-cell immunoglobulin-and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus</title><title>Cellular & molecular immunology</title><addtitle>Cell Mol Immunol</addtitle><addtitle>Cellular ＆ Molecular Immunology</addtitle><description>Systemic lupus erythematosus （SLE） is a prototypic autoimmune disease. Innate and adaptive immunity cooperatively contribute to the development of SLE. Antigen-presenting cells （APCs） have been suggested to link innate and adaptive immunity. T-cell immunoglobulin- and mucin-domain-containing molecule-4 （Tim-4; also known as Timd4）, expressed primarily on the surface of APCs, is a member of the TIM family, a recently described group of molecules that have received much attention as potential regulators of the immune system. In this study, we used quantitative real-time reverse transcription-polymerase chain reaction to examine the mRNA expression of Tim-4 in peripheral blood mononuclear cells （PBMCs） from SLE patients and further analyzed the correlation between the expression of Tim-4 and Tim- 1 （a potential l igand for Tim-4） in PB MCs and serum tumor necrosis factor （TNF）-a levels. The results showed that Tim-4 mRNA expression in PBMCs was significantly higher in SLE patients than in healthy controls, especially those patients in the active phase of disease. Moreover, Tim-4 mRNA levels were closely correlated with Tim- 1 mRNA levels in PBMCs and with serum TNF-a levels in SLE patients but not in the control group. Taken together, these results demonstrate that Tim-4 may be involved in the pathogenesis of SLE.</description><subject>Adaptive immunity</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies</subject><subject>Antigen-presenting cells</subject><subject>Autoimmune diseases</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Child</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Hepatitis A Virus Cellular Receptor 1</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunoglobulins</subject><subject>Immunology</subject><subject>Leukocytes (mononuclear)</subject><subject>Leukocytes - immunology</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - blood</subject><subject>Lupus Erythematosus, Systemic - genetics</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - immunology</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>mRNA水平</subject><subject>Mucin</subject><subject>Peripheral blood mononuclear cells</subject><subject>Receptors, Virus - genetics</subject><subject>research-article</subject><subject>Reverse transcription</subject><subject>RNA, Messenger - genetics</subject><subject>Systemic lupus erythematosus</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumor Necrosis Factor-alpha - immunology</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>T细胞</subject><subject>Vaccine</subject><subject>Young Adult</subject><subject>免疫球蛋白</subject><subject>外周血单个核细胞</subject><subject>粘蛋白</subject><subject>系统性红斑狼疮</subject><issn>1672-7681</issn><issn>2042-0226</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkktv1DAUhSMEokNhxxpZsGBDBttx4mSDhCoelSqxKWvL8VzPuPiR2jEwf4rfiKMZRgUhWF3L9_PxvUenqp4SvCa46V8rZ9YU42FNSH-vWlHMaI0p7e5XK9JxWvOuJ2fVo5RuMG57xtnD6oxiwjAmZFX9uPQqgkywQfB9ipCSCR4FjXbZSY-uawXWIuNc9mFrw5it8bX0G-SyKqdNcLIUFfxcqvFb5IIFlS3UDBmPJohm2kGUFo02hPIs-OCzsiAjWqQT0jE4NMnZgJ8T-mbmHUr7NINDNk85IYj7eQdOziHl9Lh6oKVN8ORYz6vP799dX3ysrz59uLx4e1WrtiNzrSkdh7FTGmsgwBrSS9xTDQ3huB-oxpizXg90GEivOqaBl8uWUIX5WAzsmvPqzUF3yqODjSqzlR3EFI2TcS-CNOL3jjc7sQ1fxWJrP-Ai8PIoEMNthjQLZ9KysPQQchK8ZS1r2ND_n2wajjvetIV88Qd5E3L0xQdBeVeywFo-_IsivG95yzFjhXp1oFQMKUXQp90IFkuuRMmVWHIlSq4K_uyuHyf4V5AKUB-AVFp-C_HOr38XRAfeyzlHOAkWaGEOyPPjiLvgt7dFVYxSfdHGgmiaEnPW0eYnvk_xkw</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Zhao, Peiqing</creator><creator>Xu, Liyun</creator><creator>Wang, Piming</creator><creator>Liang, Xiaohong</creator><creator>Qi, Jianni</creator><creator>Liu, Peng</creator><creator>Guo, Chun</creator><creator>Zhang, Lining</creator><creator>Ma, Chunhong</creator><creator>Gao, Lifen</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W95</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20100301</creationdate><title>Increased expression of human T-cell immunoglobulin-and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus</title><author>Zhao, Peiqing ; Xu, Liyun ; Wang, Piming ; Liang, Xiaohong ; Qi, Jianni ; Liu, Peng ; Guo, Chun ; Zhang, Lining ; Ma, Chunhong ; Gao, Lifen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-f22b9b6cf0fe1e4318a082fe3170892f00748f929918c64fe792f512c07b20463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adaptive immunity</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies</topic><topic>Antigen-presenting cells</topic><topic>Autoimmune diseases</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Child</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>Hepatitis A Virus Cellular Receptor 1</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunoglobulins</topic><topic>Immunology</topic><topic>Leukocytes (mononuclear)</topic><topic>Leukocytes - immunology</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - blood</topic><topic>Lupus Erythematosus, Systemic - genetics</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - immunology</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>mRNA水平</topic><topic>Mucin</topic><topic>Peripheral blood mononuclear cells</topic><topic>Receptors, Virus - genetics</topic><topic>research-article</topic><topic>Reverse transcription</topic><topic>RNA, Messenger - genetics</topic><topic>Systemic lupus erythematosus</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor Necrosis Factor-alpha - immunology</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>T细胞</topic><topic>Vaccine</topic><topic>Young Adult</topic><topic>免疫球蛋白</topic><topic>外周血单个核细胞</topic><topic>粘蛋白</topic><topic>系统性红斑狼疮</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Peiqing</creatorcontrib><creatorcontrib>Xu, Liyun</creatorcontrib><creatorcontrib>Wang, Piming</creatorcontrib><creatorcontrib>Liang, Xiaohong</creatorcontrib><creatorcontrib>Qi, Jianni</creatorcontrib><creatorcontrib>Liu, Peng</creatorcontrib><creatorcontrib>Guo, Chun</creatorcontrib><creatorcontrib>Zhang, Lining</creatorcontrib><creatorcontrib>Ma, Chunhong</creatorcontrib><creatorcontrib>Gao, Lifen</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-农业科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular & molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Peiqing</au><au>Xu, Liyun</au><au>Wang, Piming</au><au>Liang, Xiaohong</au><au>Qi, Jianni</au><au>Liu, Peng</au><au>Guo, Chun</au><au>Zhang, Lining</au><au>Ma, Chunhong</au><au>Gao, Lifen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased expression of human T-cell immunoglobulin-and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus</atitle><jtitle>Cellular & molecular immunology</jtitle><stitle>Cell Mol Immunol</stitle><addtitle>Cellular ＆ Molecular Immunology</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>7</volume><issue>2</issue><spage>152</spage><epage>156</epage><pages>152-156</pages><issn>1672-7681</issn><eissn>2042-0226</eissn><abstract>Systemic lupus erythematosus （SLE） is a prototypic autoimmune disease. Innate and adaptive immunity cooperatively contribute to the development of SLE. Antigen-presenting cells （APCs） have been suggested to link innate and adaptive immunity. T-cell immunoglobulin- and mucin-domain-containing molecule-4 （Tim-4; also known as Timd4）, expressed primarily on the surface of APCs, is a member of the TIM family, a recently described group of molecules that have received much attention as potential regulators of the immune system. In this study, we used quantitative real-time reverse transcription-polymerase chain reaction to examine the mRNA expression of Tim-4 in peripheral blood mononuclear cells （PBMCs） from SLE patients and further analyzed the correlation between the expression of Tim-4 and Tim- 1 （a potential l igand for Tim-4） in PB MCs and serum tumor necrosis factor （TNF）-a levels. The results showed that Tim-4 mRNA expression in PBMCs was significantly higher in SLE patients than in healthy controls, especially those patients in the active phase of disease. Moreover, Tim-4 mRNA levels were closely correlated with Tim- 1 mRNA levels in PBMCs and with serum TNF-a levels in SLE patients but not in the control group. Taken together, these results demonstrate that Tim-4 may be involved in the pathogenesis of SLE.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20140011</pmid><doi>10.1038/cmi.2009.118</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cellular & molecular immunology, 2010-03, Vol.7 (2), p.152-156 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adaptive immunity Adolescent Adult Antibodies Antigen-presenting cells Autoimmune diseases Biomedical and Life Sciences Biomedicine Child Female Gene expression Gene Expression Regulation Hepatitis A Virus Cellular Receptor 1 Humans Immune system Immunoglobulins Immunology Leukocytes (mononuclear) Leukocytes - immunology Lupus Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lymphocytes T Male Medical Microbiology Membrane Glycoproteins - genetics Membrane Proteins - genetics Membrane Proteins - immunology Microbiology Middle Aged mRNA水平 Mucin Peripheral blood mononuclear cells Receptors, Virus - genetics research-article Reverse transcription RNA, Messenger - genetics Systemic lupus erythematosus Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - immunology Tumor necrosis factor-TNF Tumor necrosis factor-α T细胞 Vaccine Young Adult 免疫球蛋白 外周血单个核细胞 粘蛋白 系统性红斑狼疮 |
| title | Increased expression of human T-cell immunoglobulin-and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus |
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