Betulinic acid inhibits autophagic flux and induces apoptosis in human multiple myeloma cells in vitro

Aim： To investigate the effects of betulinic acid （BA） on apoptosis and autophagic flux in multiple myeloma cells and the relationship between the two processes. Methods： The proliferation of human multiple myeloma KM3 cells was measured with MTT assay. FITC/PI double-labeled flow cytom- etry （FCM）...

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Veröffentlicht in:	Acta pharmacologica Sinica 2012-12, Vol.33 (12), p.1542-1548
Hauptverfasser:	Yang, Li-jing, Chen, Yan, He, Jing, Yi, Sha, Wen, Lu, Zhao, Jie, Zhang, Ben-ping, Cui, Guo-hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis - drug effects Autophagy - drug effects Biomedical and Life Sciences Biomedicine Blotting, Western Caspase 3 - metabolism Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Humans Immunology Internal Medicine Medical Microbiology Multiple Myeloma - drug therapy Multiple Myeloma - pathology Oligopeptides - pharmacology Original original-article Pharmacology/Toxicology Triterpenes - pharmacology Triterpenes - therapeutic use Vaccine 人类体外诱导多发性骨髓瘤桦木细胞凋亡自噬通量骨髓瘤细胞
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