Bovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus

Bovine lactoferrin (bLf) is a multifunctional glycoprotein that plays an important role in innate immunity against infections, including influenza. Here we have dissected bLf into its C- and N-lobes and show that inhibition of influenza virus hemagglutination and cell infection is entirely attributa...

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Veröffentlicht in:	Pathogens and global health 2012-03, Vol.106 (1), p.12-19
Hauptverfasser:	Ammendolia, Maria Grazia, Agamennone, Mariangela, Pietrantoni, Agostina, Lannutti, Fabio, Siciliano, Rosa Anna, De Giulio, Beatrice, Amici, Carla, Superti, Fabiana
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antiviral Antiviral Agents - metabolism Antiviral Agents - pharmacology Biological and medical sciences Bovine lactoferrin C-lobe Cells, Cultured Dogs Drug Evaluation, Preclinical - methods General aspects Hemagglutinins - metabolism Human viral diseases Infectious diseases Influenza Influenza virus Lactoferrin - genetics Lactoferrin - metabolism Lactoferrin - pharmacology Medical sciences Molecular Sequence Data Original Orthomyxoviridae - drug effects Orthomyxoviridae - metabolism Peptide Fragments - genetics Peptide Fragments - metabolism Peptide Fragments - pharmacology Peptides Protein Binding Sequence Alignment Viral diseases Viral diseases of the respiratory system and ent viral diseases
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