Controlled attenuation parameter for non-invasive assessment of hepatic steatosis in Chinese patients
AIM:To evaluate the performance of a novel non-invasive controlled attenuation parameter(CAP)to assess liver steatosis.METHODS:This was a multi-center prospective cohort study.Consecutive patients(aged≥18 years)who had undergone percutaneous liver biopsy and CAP measurement were recruited from three...
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| creator | Shen, Feng Zheng, Rui-Dan Mi, Yu-Qiang Wang, Xiao-Ying Pan, Qin Chen, Guang-Yu Cao, Hai-Xia Chen, Ming-Li Xu, Liang Chen, Jian-Neng Cao, Yi Zhang, Rui-Nan Xu, Lei-Ming Fan, Jian-Gao |
| description | AIM:To evaluate the performance of a novel non-invasive controlled attenuation parameter(CAP)to assess liver steatosis.METHODS:This was a multi-center prospective cohort study.Consecutive patients(aged≥18 years)who had undergone percutaneous liver biopsy and CAP measurement were recruited from three Chinese liver centers.Steatosis was categorized as S0:<5%;S1:5%-33%;S2:34%-66%;or S3:≥67%,according to the nonalcoholic fatty liver disease(NAFLD)activity score.The FibroScan?502 equipped with the M probe(Echosens,Paris,France)was used to capture both CAP and liver stiffness measurement values simultaneously.Receiver operating characteristic curves were plotted,and the areas under the curves were calculated to determine the diagnostic efficacy.The accuracy of the CAP values at the optimal thresholds was defined by maximizing the sum of sensitivity and specificity(maximum Youden index).RESULTS:A total of 152 patients were recruited,including 52(34.2%)patients with NAFLD and 100(65.8%)with chronic hepatitis B(CHB)virus infection.After adjustment,the steatosis grade(OR=37.12;95%CI:21.63-52.60,P<0.001)and body mass index(BMI,OR=6.20;95%CI:2.92-9.48,P<0.001)were found independently associated with CAP by multivariate linear regression analysis.CAP was not influenced by inflammation,fibrosis or aetiology.The median CAP values and interquartile ranges among patients with S0,S1,S2 and S3 steatosis were 211(181-240)dB/m,270(253-305)dB/m,330(302-360)dB/m,and 346(313-363)dB/m,respectively.The cut-offs for the CAP values in all patients with steatosis≥5%,≥34%and≥67%were 253 dB/m,285 dB/m and 310 dB/m,respectively.The areas under the curves were 0.92,0.92and 0.88 for steatosis≥5%,≥34%and≥67%,respectively.No significant differences were found in the CAP values between the NAFLD group and the CHB group in each steatosis grade.CONCLUSION:CAP appears to be a promising tool for the non-invasive detection and quantification of hepatic steatosis,but is limited by BMI. |
| doi_str_mv | 10.3748/wjg.v20.i16.4702 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4000506</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>90888889504849524954485051</cqvip_id><sourcerecordid>24782622</sourcerecordid><originalsourceid>FETCH-LOGICAL-c506t-57b62fbd3304673b54dc94d193c167e5ad5298c56955d341023443296af3de103</originalsourceid><addsrcrecordid>eNpVkFtLAzEQhYMotl7efZL8ga2T2-7mRZDiDQRf9Dmku7NtSpvUJFb896aoRQNDHuacMzMfIRcMJqKR7dXHcj7Zcpg4Vk9kA_yAjDlnuuKthEMyZgBNpQVvRuQkpSUAF0LxYzLisml5zfmY4DT4HMNqhT21OaN_t9kFTzc22jVmjHQIkfrgK-e3NrktUpsSprRGn2kY6AI3xdHRlNHmkFyiztPpwnlMSHetoktn5Giwq4TnP_8peb27fZk-VE_P94_Tm6eqU1DnSjWzmg-zXgiQdSNmSvadlj3TomN1g8r2iuu2U7VWqheSlXukFFzXdhA9MhCn5Po7d_M-W2PfldnRrswmurWNnyZYZ_53vFuYedgaCQBlhRIA3wFdDClFHPZeBmaH3BTkpiA3BbnZIS-Wy78z94ZfxkUgfjIXwc_fnJ_vNRra3dMKZCu14qWkbBUoJr4AY-SP7w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Controlled attenuation parameter for non-invasive assessment of hepatic steatosis in Chinese patients</title><source>PubMed Central (Open Access)</source><source>MEDLINE</source><source>Baishideng "World Journal of" online journals</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Shen, Feng ; Zheng, Rui-Dan ; Mi, Yu-Qiang ; Wang, Xiao-Ying ; Pan, Qin ; Chen, Guang-Yu ; Cao, Hai-Xia ; Chen, Ming-Li ; Xu, Liang ; Chen, Jian-Neng ; Cao, Yi ; Zhang, Rui-Nan ; Xu, Lei-Ming ; Fan, Jian-Gao</creator><creatorcontrib>Shen, Feng ; Zheng, Rui-Dan ; Mi, Yu-Qiang ; Wang, Xiao-Ying ; Pan, Qin ; Chen, Guang-Yu ; Cao, Hai-Xia ; Chen, Ming-Li ; Xu, Liang ; Chen, Jian-Neng ; Cao, Yi ; Zhang, Rui-Nan ; Xu, Lei-Ming ; Fan, Jian-Gao</creatorcontrib><description>AIM:To evaluate the performance of a novel non-invasive controlled attenuation parameter(CAP)to assess liver steatosis.METHODS:This was a multi-center prospective cohort study.Consecutive patients(aged≥18 years)who had undergone percutaneous liver biopsy and CAP measurement were recruited from three Chinese liver centers.Steatosis was categorized as S0:&lt;5%;S1:5%-33%;S2:34%-66%;or S3:≥67%,according to the nonalcoholic fatty liver disease(NAFLD)activity score.The FibroScan?502 equipped with the M probe(Echosens,Paris,France)was used to capture both CAP and liver stiffness measurement values simultaneously.Receiver operating characteristic curves were plotted,and the areas under the curves were calculated to determine the diagnostic efficacy.The accuracy of the CAP values at the optimal thresholds was defined by maximizing the sum of sensitivity and specificity(maximum Youden index).RESULTS:A total of 152 patients were recruited,including 52(34.2%)patients with NAFLD and 100(65.8%)with chronic hepatitis B(CHB)virus infection.After adjustment,the steatosis grade(OR=37.12;95%CI:21.63-52.60,P&lt;0.001)and body mass index(BMI,OR=6.20;95%CI:2.92-9.48,P&lt;0.001)were found independently associated with CAP by multivariate linear regression analysis.CAP was not influenced by inflammation,fibrosis or aetiology.The median CAP values and interquartile ranges among patients with S0,S1,S2 and S3 steatosis were 211(181-240)dB/m,270(253-305)dB/m,330(302-360)dB/m,and 346(313-363)dB/m,respectively.The cut-offs for the CAP values in all patients with steatosis≥5%,≥34%and≥67%were 253 dB/m,285 dB/m and 310 dB/m,respectively.The areas under the curves were 0.92,0.92and 0.88 for steatosis≥5%,≥34%and≥67%,respectively.No significant differences were found in the CAP values between the NAFLD group and the CHB group in each steatosis grade.CONCLUSION:CAP appears to be a promising tool for the non-invasive detection and quantification of hepatic steatosis,but is limited by BMI.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v20.i16.4702</identifier><identifier>PMID: 24782622</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Co., Limited</publisher><subject>Adult ; Area Under Curve ; Asian Continental Ancestry Group ; attenuation ; Biopsy ; Body Mass Index ; Brief ; Chi-Square Distribution ; China ; Controlled ; Elasticity Imaging Techniques ; Fatty ; Female ; Humans ; Linear Models ; liver ; Liver - pathology ; Male ; Middle Aged ; Multivariate Analysis ; Non-alcoholic Fatty Liver Disease - ethnology ; Non-alcoholic Fatty Liver Disease - pathology ; Nonalcoholic ; Odds Ratio ; Predictive Value of Tests ; Prospective Studies ; Risk Factors ; ROC Curve ; Severity of Illness Index</subject><ispartof>World journal of gastroenterology : WJG, 2014-04, Vol.20 (16), p.4702-4711</ispartof><rights>2014 Baishideng Publishing Group Co., Limited. All rights reserved. 2014</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-57b62fbd3304673b54dc94d193c167e5ad5298c56955d341023443296af3de103</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000506/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000506/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24782622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Feng</creatorcontrib><creatorcontrib>Zheng, Rui-Dan</creatorcontrib><creatorcontrib>Mi, Yu-Qiang</creatorcontrib><creatorcontrib>Wang, Xiao-Ying</creatorcontrib><creatorcontrib>Pan, Qin</creatorcontrib><creatorcontrib>Chen, Guang-Yu</creatorcontrib><creatorcontrib>Cao, Hai-Xia</creatorcontrib><creatorcontrib>Chen, Ming-Li</creatorcontrib><creatorcontrib>Xu, Liang</creatorcontrib><creatorcontrib>Chen, Jian-Neng</creatorcontrib><creatorcontrib>Cao, Yi</creatorcontrib><creatorcontrib>Zhang, Rui-Nan</creatorcontrib><creatorcontrib>Xu, Lei-Ming</creatorcontrib><creatorcontrib>Fan, Jian-Gao</creatorcontrib><title>Controlled attenuation parameter for non-invasive assessment of hepatic steatosis in Chinese patients</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM:To evaluate the performance of a novel non-invasive controlled attenuation parameter(CAP)to assess liver steatosis.METHODS:This was a multi-center prospective cohort study.Consecutive patients(aged≥18 years)who had undergone percutaneous liver biopsy and CAP measurement were recruited from three Chinese liver centers.Steatosis was categorized as S0:&lt;5%;S1:5%-33%;S2:34%-66%;or S3:≥67%,according to the nonalcoholic fatty liver disease(NAFLD)activity score.The FibroScan?502 equipped with the M probe(Echosens,Paris,France)was used to capture both CAP and liver stiffness measurement values simultaneously.Receiver operating characteristic curves were plotted,and the areas under the curves were calculated to determine the diagnostic efficacy.The accuracy of the CAP values at the optimal thresholds was defined by maximizing the sum of sensitivity and specificity(maximum Youden index).RESULTS:A total of 152 patients were recruited,including 52(34.2%)patients with NAFLD and 100(65.8%)with chronic hepatitis B(CHB)virus infection.After adjustment,the steatosis grade(OR=37.12;95%CI:21.63-52.60,P&lt;0.001)and body mass index(BMI,OR=6.20;95%CI:2.92-9.48,P&lt;0.001)were found independently associated with CAP by multivariate linear regression analysis.CAP was not influenced by inflammation,fibrosis or aetiology.The median CAP values and interquartile ranges among patients with S0,S1,S2 and S3 steatosis were 211(181-240)dB/m,270(253-305)dB/m,330(302-360)dB/m,and 346(313-363)dB/m,respectively.The cut-offs for the CAP values in all patients with steatosis≥5%,≥34%and≥67%were 253 dB/m,285 dB/m and 310 dB/m,respectively.The areas under the curves were 0.92,0.92and 0.88 for steatosis≥5%,≥34%and≥67%,respectively.No significant differences were found in the CAP values between the NAFLD group and the CHB group in each steatosis grade.CONCLUSION:CAP appears to be a promising tool for the non-invasive detection and quantification of hepatic steatosis,but is limited by BMI.</description><subject>Adult</subject><subject>Area Under Curve</subject><subject>Asian Continental Ancestry Group</subject><subject>attenuation</subject><subject>Biopsy</subject><subject>Body Mass Index</subject><subject>Brief</subject><subject>Chi-Square Distribution</subject><subject>China</subject><subject>Controlled</subject><subject>Elasticity Imaging Techniques</subject><subject>Fatty</subject><subject>Female</subject><subject>Humans</subject><subject>Linear Models</subject><subject>liver</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Non-alcoholic Fatty Liver Disease - ethnology</subject><subject>Non-alcoholic Fatty Liver Disease - pathology</subject><subject>Nonalcoholic</subject><subject>Odds Ratio</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Severity of Illness Index</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkFtLAzEQhYMotl7efZL8ga2T2-7mRZDiDQRf9Dmku7NtSpvUJFb896aoRQNDHuacMzMfIRcMJqKR7dXHcj7Zcpg4Vk9kA_yAjDlnuuKthEMyZgBNpQVvRuQkpSUAF0LxYzLisml5zfmY4DT4HMNqhT21OaN_t9kFTzc22jVmjHQIkfrgK-e3NrktUpsSprRGn2kY6AI3xdHRlNHmkFyiztPpwnlMSHetoktn5Giwq4TnP_8peb27fZk-VE_P94_Tm6eqU1DnSjWzmg-zXgiQdSNmSvadlj3TomN1g8r2iuu2U7VWqheSlXukFFzXdhA9MhCn5Po7d_M-W2PfldnRrswmurWNnyZYZ_53vFuYedgaCQBlhRIA3wFdDClFHPZeBmaH3BTkpiA3BbnZIS-Wy78z94ZfxkUgfjIXwc_fnJ_vNRra3dMKZCu14qWkbBUoJr4AY-SP7w</recordid><startdate>20140428</startdate><enddate>20140428</enddate><creator>Shen, Feng</creator><creator>Zheng, Rui-Dan</creator><creator>Mi, Yu-Qiang</creator><creator>Wang, Xiao-Ying</creator><creator>Pan, Qin</creator><creator>Chen, Guang-Yu</creator><creator>Cao, Hai-Xia</creator><creator>Chen, Ming-Li</creator><creator>Xu, Liang</creator><creator>Chen, Jian-Neng</creator><creator>Cao, Yi</creator><creator>Zhang, Rui-Nan</creator><creator>Xu, Lei-Ming</creator><creator>Fan, Jian-Gao</creator><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20140428</creationdate><title>Controlled attenuation parameter for non-invasive assessment of hepatic steatosis in Chinese patients</title><author>Shen, Feng ; Zheng, Rui-Dan ; Mi, Yu-Qiang ; Wang, Xiao-Ying ; Pan, Qin ; Chen, Guang-Yu ; Cao, Hai-Xia ; Chen, Ming-Li ; Xu, Liang ; Chen, Jian-Neng ; Cao, Yi ; Zhang, Rui-Nan ; Xu, Lei-Ming ; Fan, Jian-Gao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-57b62fbd3304673b54dc94d193c167e5ad5298c56955d341023443296af3de103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Area Under Curve</topic><topic>Asian Continental Ancestry Group</topic><topic>attenuation</topic><topic>Biopsy</topic><topic>Body Mass Index</topic><topic>Brief</topic><topic>Chi-Square Distribution</topic><topic>China</topic><topic>Controlled</topic><topic>Elasticity Imaging Techniques</topic><topic>Fatty</topic><topic>Female</topic><topic>Humans</topic><topic>Linear Models</topic><topic>liver</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Non-alcoholic Fatty Liver Disease - ethnology</topic><topic>Non-alcoholic Fatty Liver Disease - pathology</topic><topic>Nonalcoholic</topic><topic>Odds Ratio</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Severity of Illness Index</topic><toplevel>online_resources</toplevel><creatorcontrib>Shen, Feng</creatorcontrib><creatorcontrib>Zheng, Rui-Dan</creatorcontrib><creatorcontrib>Mi, Yu-Qiang</creatorcontrib><creatorcontrib>Wang, Xiao-Ying</creatorcontrib><creatorcontrib>Pan, Qin</creatorcontrib><creatorcontrib>Chen, Guang-Yu</creatorcontrib><creatorcontrib>Cao, Hai-Xia</creatorcontrib><creatorcontrib>Chen, Ming-Li</creatorcontrib><creatorcontrib>Xu, Liang</creatorcontrib><creatorcontrib>Chen, Jian-Neng</creatorcontrib><creatorcontrib>Cao, Yi</creatorcontrib><creatorcontrib>Zhang, Rui-Nan</creatorcontrib><creatorcontrib>Xu, Lei-Ming</creatorcontrib><creatorcontrib>Fan, Jian-Gao</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Feng</au><au>Zheng, Rui-Dan</au><au>Mi, Yu-Qiang</au><au>Wang, Xiao-Ying</au><au>Pan, Qin</au><au>Chen, Guang-Yu</au><au>Cao, Hai-Xia</au><au>Chen, Ming-Li</au><au>Xu, Liang</au><au>Chen, Jian-Neng</au><au>Cao, Yi</au><au>Zhang, Rui-Nan</au><au>Xu, Lei-Ming</au><au>Fan, Jian-Gao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controlled attenuation parameter for non-invasive assessment of hepatic steatosis in Chinese patients</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2014-04-28</date><risdate>2014</risdate><volume>20</volume><issue>16</issue><spage>4702</spage><epage>4711</epage><pages>4702-4711</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM:To evaluate the performance of a novel non-invasive controlled attenuation parameter(CAP)to assess liver steatosis.METHODS:This was a multi-center prospective cohort study.Consecutive patients(aged≥18 years)who had undergone percutaneous liver biopsy and CAP measurement were recruited from three Chinese liver centers.Steatosis was categorized as S0:&lt;5%;S1:5%-33%;S2:34%-66%;or S3:≥67%,according to the nonalcoholic fatty liver disease(NAFLD)activity score.The FibroScan?502 equipped with the M probe(Echosens,Paris,France)was used to capture both CAP and liver stiffness measurement values simultaneously.Receiver operating characteristic curves were plotted,and the areas under the curves were calculated to determine the diagnostic efficacy.The accuracy of the CAP values at the optimal thresholds was defined by maximizing the sum of sensitivity and specificity(maximum Youden index).RESULTS:A total of 152 patients were recruited,including 52(34.2%)patients with NAFLD and 100(65.8%)with chronic hepatitis B(CHB)virus infection.After adjustment,the steatosis grade(OR=37.12;95%CI:21.63-52.60,P&lt;0.001)and body mass index(BMI,OR=6.20;95%CI:2.92-9.48,P&lt;0.001)were found independently associated with CAP by multivariate linear regression analysis.CAP was not influenced by inflammation,fibrosis or aetiology.The median CAP values and interquartile ranges among patients with S0,S1,S2 and S3 steatosis were 211(181-240)dB/m,270(253-305)dB/m,330(302-360)dB/m,and 346(313-363)dB/m,respectively.The cut-offs for the CAP values in all patients with steatosis≥5%,≥34%and≥67%were 253 dB/m,285 dB/m and 310 dB/m,respectively.The areas under the curves were 0.92,0.92and 0.88 for steatosis≥5%,≥34%and≥67%,respectively.No significant differences were found in the CAP values between the NAFLD group and the CHB group in each steatosis grade.CONCLUSION:CAP appears to be a promising tool for the non-invasive detection and quantification of hepatic steatosis,but is limited by BMI.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Co., Limited</pub><pmid>24782622</pmid><doi>10.3748/wjg.v20.i16.4702</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Area Under Curve Asian Continental Ancestry Group attenuation Biopsy Body Mass Index Brief Chi-Square Distribution China Controlled Elasticity Imaging Techniques Fatty Female Humans Linear Models liver Liver - pathology Male Middle Aged Multivariate Analysis Non-alcoholic Fatty Liver Disease - ethnology Non-alcoholic Fatty Liver Disease - pathology Nonalcoholic Odds Ratio Predictive Value of Tests Prospective Studies Risk Factors ROC Curve Severity of Illness Index |
| title | Controlled attenuation parameter for non-invasive assessment of hepatic steatosis in Chinese patients |
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