Relationship of Progesterone, Bovine Pregnancy-Associated Glycoprotein-1 and Nitric Oxide with Late Embryonic and Early Fetal Mortalities in Dairy Cows
The aim of the present study was to determine the relationship of progesterone (P4), bovine pregnancy-associated glycoprotein-1 (bPAG-1) and nitric oxide (NO) levels with late embryonic (LEM; day 28 to day 42) and early fetal mortalities (EFM; > day 42 to day 56) in dairy cows. Transrectal ultras...
Gespeichert in:
| Veröffentlicht in: | Journal of Reproduction and Development 2014, Vol.60(2), pp.162-167 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 167 |
|---|---|
| container_issue | 2 |
| container_start_page | 162 |
| container_title | Journal of Reproduction and Development |
| container_volume | 60 |
| creator | KAREN, Aly BAJCSY, Árpád Csaba MINOIA, Rosa KOVÁCS, Rezső SOUSA, Noelita Melo DE BECKERS, Jean-François TIBOLD, János MÁDL, István SZENCI, Ottó |
| description | The aim of the present study was to determine the relationship of progesterone (P4), bovine pregnancy-associated glycoprotein-1 (bPAG-1) and nitric oxide (NO) levels with late embryonic (LEM; day 28 to day 42) and early fetal mortalities (EFM; > day 42 to day 56) in dairy cows. Transrectal ultrasonography (6–8 MHz) was performed in 100 Holstein-Friesian cows at days 28, 42 and 56 after artificial insemination (AI; day 0) to diagnose pregnancy and to monitor the fate of the embryo. After ultrasound scanning of each cow, a milk sample was collected for assessment of P4 by an ELISA test and a blood sample was collected for assessment of bPAG-1, by using a double-antibody radioimmunoassay, and serum NO metabolites (nitrate + nitrite). Based on ultrasonographic examinations and bPAG-1-RIA, 41 of 100 inseminated cows were confirmed pregnant at day 28 after AI. Nine cows suffered of LEM, and 6 cows suffered of EFM and the overall pregnancy loss rate was 36.6% (15/41) between days 28 and 56 of pregnancy. By logistic regression analysis, there were no significant relationships between the level of P4 and bPAG-1 at day 28 after AI and the occurrence of LEM and EFM. Also, there were no significant relationships between the levels of P4 and bPAG-1 at day 42 and the occurrence of EFM. On the other hand, a significant relationship (P |
| doi_str_mv | 10.1262/jrd.2013-033 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_liege</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3999396</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>24531657</sourcerecordid><originalsourceid>FETCH-LOGICAL-c544t-f977a16f95e0b0248e03f9174f18c6c9a70025b898feb3daf59c53f3530c614a3</originalsourceid><addsrcrecordid>eNpVkc1uEzEUhUcIRENhxxr5ATrFf_PjDVKbpgUpUIRgbXk81xNHEzuy3ZR5El4XJ2kj2PhaPt89PtIpivcEXxJa04_r0F9STFiJGXtRzAjjbck5xi-LGRakLtuWtGfFmxjXGDNa1fx1cUZ5xUhdNbPizw8YVbLexZXdIm_Q9-AHiAmCd3CBrv3OOsiPMDjl9FRexei1VQl6dDdO2m-DT2BdSZByPfpmU7Aa3f-2PaBHm1ZomVG02HRh8i4re2ihwjihW0hqRF99yMMmCxFZh26UDROa-8f4tnhl1Bjh3dM8L37dLn7OP5fL-7sv86tlqSvOU2lE0yhSG1EB7jDlLWBmBGm4Ia2utVANxrTqWtEa6FivTCV0xQyrGNY14YqdF5-OvtuHbgO9BpeCGuU22I0Kk_TKyv8VZ1dy8DvJhBBM1NmAHQ1GCwNIHzord_SweLg_jINUWnYgKa1bmaNxxvPWxXFLBx9jAHP6kWC5r1XmWuW-VplrzfiHf1Oe4OceM3B9BNYxqRzjGVAhWT3Cwa3Gkh6OJ9eTqFcqSHDsL6uPuLI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Relationship of Progesterone, Bovine Pregnancy-Associated Glycoprotein-1 and Nitric Oxide with Late Embryonic and Early Fetal Mortalities in Dairy Cows</title><source>J-STAGE Free</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>KAREN, Aly ; BAJCSY, Árpád Csaba ; MINOIA, Rosa ; KOVÁCS, Rezső ; SOUSA, Noelita Melo DE ; BECKERS, Jean-François ; TIBOLD, János ; MÁDL, István ; SZENCI, Ottó</creator><creatorcontrib>KAREN, Aly ; BAJCSY, Árpád Csaba ; MINOIA, Rosa ; KOVÁCS, Rezső ; SOUSA, Noelita Melo DE ; BECKERS, Jean-François ; TIBOLD, János ; MÁDL, István ; SZENCI, Ottó</creatorcontrib><description>The aim of the present study was to determine the relationship of progesterone (P4), bovine pregnancy-associated glycoprotein-1 (bPAG-1) and nitric oxide (NO) levels with late embryonic (LEM; day 28 to day 42) and early fetal mortalities (EFM; > day 42 to day 56) in dairy cows. Transrectal ultrasonography (6–8 MHz) was performed in 100 Holstein-Friesian cows at days 28, 42 and 56 after artificial insemination (AI; day 0) to diagnose pregnancy and to monitor the fate of the embryo. After ultrasound scanning of each cow, a milk sample was collected for assessment of P4 by an ELISA test and a blood sample was collected for assessment of bPAG-1, by using a double-antibody radioimmunoassay, and serum NO metabolites (nitrate + nitrite). Based on ultrasonographic examinations and bPAG-1-RIA, 41 of 100 inseminated cows were confirmed pregnant at day 28 after AI. Nine cows suffered of LEM, and 6 cows suffered of EFM and the overall pregnancy loss rate was 36.6% (15/41) between days 28 and 56 of pregnancy. By logistic regression analysis, there were no significant relationships between the level of P4 and bPAG-1 at day 28 after AI and the occurrence of LEM and EFM. Also, there were no significant relationships between the levels of P4 and bPAG-1 at day 42 and the occurrence of EFM. On the other hand, a significant relationship (P<0.05) was found between NO level at day 28 and the occurrence of LEM. In conclusion, measurement of the serum NO concentration at day 28 of pregnancy might help to predict the outcome of pregnancy by day 42 in dairy cows but further studies are needed to confirm this.</description><identifier>ISSN: 0916-8818</identifier><identifier>ISSN: 1348-4400</identifier><identifier>EISSN: 1348-4400</identifier><identifier>DOI: 10.1262/jrd.2013-033</identifier><identifier>PMID: 24531657</identifier><language>eng</language><publisher>Japan: THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT</publisher><subject>Animals ; Aspartic Acid Endopeptidases - blood ; Aspartic Acid Endopeptidases - metabolism ; Bovine pregnancy associated glycoprotein-1 ; Cattle - blood ; Cattle - embryology ; Cattle - metabolism ; Dairy cow ; Female ; Fetal Death ; Life sciences ; Logistic Models ; Médecine vétérinaire & santé animale ; Nitric oxide ; Nitric Oxide - blood ; Nitric Oxide - metabolism ; Original ; Pregnancy ; Pregnancy associated glycoprotein ; Pregnancy loss ; Pregnancy Proteins - blood ; Pregnancy Proteins - metabolism ; Progesterone ; Progesterone - metabolism ; Sciences du vivant ; Veterinary medicine & animal health</subject><ispartof>Journal of Reproduction and Development, 2014, Vol.60(2), pp.162-167</ispartof><rights>2014 Society for Reproduction and Development</rights><rights>2014 Society for Reproduction and Development 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-f977a16f95e0b0248e03f9174f18c6c9a70025b898feb3daf59c53f3530c614a3</citedby><cites>FETCH-LOGICAL-c544t-f977a16f95e0b0248e03f9174f18c6c9a70025b898feb3daf59c53f3530c614a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999396/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999396/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1881,4022,27922,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24531657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAREN, Aly</creatorcontrib><creatorcontrib>BAJCSY, Árpád Csaba</creatorcontrib><creatorcontrib>MINOIA, Rosa</creatorcontrib><creatorcontrib>KOVÁCS, Rezső</creatorcontrib><creatorcontrib>SOUSA, Noelita Melo DE</creatorcontrib><creatorcontrib>BECKERS, Jean-François</creatorcontrib><creatorcontrib>TIBOLD, János</creatorcontrib><creatorcontrib>MÁDL, István</creatorcontrib><creatorcontrib>SZENCI, Ottó</creatorcontrib><title>Relationship of Progesterone, Bovine Pregnancy-Associated Glycoprotein-1 and Nitric Oxide with Late Embryonic and Early Fetal Mortalities in Dairy Cows</title><title>Journal of Reproduction and Development</title><addtitle>J. Reprod. Dev.</addtitle><description>The aim of the present study was to determine the relationship of progesterone (P4), bovine pregnancy-associated glycoprotein-1 (bPAG-1) and nitric oxide (NO) levels with late embryonic (LEM; day 28 to day 42) and early fetal mortalities (EFM; > day 42 to day 56) in dairy cows. Transrectal ultrasonography (6–8 MHz) was performed in 100 Holstein-Friesian cows at days 28, 42 and 56 after artificial insemination (AI; day 0) to diagnose pregnancy and to monitor the fate of the embryo. After ultrasound scanning of each cow, a milk sample was collected for assessment of P4 by an ELISA test and a blood sample was collected for assessment of bPAG-1, by using a double-antibody radioimmunoassay, and serum NO metabolites (nitrate + nitrite). Based on ultrasonographic examinations and bPAG-1-RIA, 41 of 100 inseminated cows were confirmed pregnant at day 28 after AI. Nine cows suffered of LEM, and 6 cows suffered of EFM and the overall pregnancy loss rate was 36.6% (15/41) between days 28 and 56 of pregnancy. By logistic regression analysis, there were no significant relationships between the level of P4 and bPAG-1 at day 28 after AI and the occurrence of LEM and EFM. Also, there were no significant relationships between the levels of P4 and bPAG-1 at day 42 and the occurrence of EFM. On the other hand, a significant relationship (P<0.05) was found between NO level at day 28 and the occurrence of LEM. In conclusion, measurement of the serum NO concentration at day 28 of pregnancy might help to predict the outcome of pregnancy by day 42 in dairy cows but further studies are needed to confirm this.</description><subject>Animals</subject><subject>Aspartic Acid Endopeptidases - blood</subject><subject>Aspartic Acid Endopeptidases - metabolism</subject><subject>Bovine pregnancy associated glycoprotein-1</subject><subject>Cattle - blood</subject><subject>Cattle - embryology</subject><subject>Cattle - metabolism</subject><subject>Dairy cow</subject><subject>Female</subject><subject>Fetal Death</subject><subject>Life sciences</subject><subject>Logistic Models</subject><subject>Médecine vétérinaire & santé animale</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - blood</subject><subject>Nitric Oxide - metabolism</subject><subject>Original</subject><subject>Pregnancy</subject><subject>Pregnancy associated glycoprotein</subject><subject>Pregnancy loss</subject><subject>Pregnancy Proteins - blood</subject><subject>Pregnancy Proteins - metabolism</subject><subject>Progesterone</subject><subject>Progesterone - metabolism</subject><subject>Sciences du vivant</subject><subject>Veterinary medicine & animal health</subject><issn>0916-8818</issn><issn>1348-4400</issn><issn>1348-4400</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1uEzEUhUcIRENhxxr5ATrFf_PjDVKbpgUpUIRgbXk81xNHEzuy3ZR5El4XJ2kj2PhaPt89PtIpivcEXxJa04_r0F9STFiJGXtRzAjjbck5xi-LGRakLtuWtGfFmxjXGDNa1fx1cUZ5xUhdNbPizw8YVbLexZXdIm_Q9-AHiAmCd3CBrv3OOsiPMDjl9FRexei1VQl6dDdO2m-DT2BdSZByPfpmU7Aa3f-2PaBHm1ZomVG02HRh8i4re2ihwjihW0hqRF99yMMmCxFZh26UDROa-8f4tnhl1Bjh3dM8L37dLn7OP5fL-7sv86tlqSvOU2lE0yhSG1EB7jDlLWBmBGm4Ia2utVANxrTqWtEa6FivTCV0xQyrGNY14YqdF5-OvtuHbgO9BpeCGuU22I0Kk_TKyv8VZ1dy8DvJhBBM1NmAHQ1GCwNIHzord_SweLg_jINUWnYgKa1bmaNxxvPWxXFLBx9jAHP6kWC5r1XmWuW-VplrzfiHf1Oe4OceM3B9BNYxqRzjGVAhWT3Cwa3Gkh6OJ9eTqFcqSHDsL6uPuLI</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>KAREN, Aly</creator><creator>BAJCSY, Árpád Csaba</creator><creator>MINOIA, Rosa</creator><creator>KOVÁCS, Rezső</creator><creator>SOUSA, Noelita Melo DE</creator><creator>BECKERS, Jean-François</creator><creator>TIBOLD, János</creator><creator>MÁDL, István</creator><creator>SZENCI, Ottó</creator><general>THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT</general><general>The Society for Reproduction and Development</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>Q33</scope><scope>5PM</scope></search><sort><creationdate>2014</creationdate><title>Relationship of Progesterone, Bovine Pregnancy-Associated Glycoprotein-1 and Nitric Oxide with Late Embryonic and Early Fetal Mortalities in Dairy Cows</title><author>KAREN, Aly ; BAJCSY, Árpád Csaba ; MINOIA, Rosa ; KOVÁCS, Rezső ; SOUSA, Noelita Melo DE ; BECKERS, Jean-François ; TIBOLD, János ; MÁDL, István ; SZENCI, Ottó</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-f977a16f95e0b0248e03f9174f18c6c9a70025b898feb3daf59c53f3530c614a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Aspartic Acid Endopeptidases - blood</topic><topic>Aspartic Acid Endopeptidases - metabolism</topic><topic>Bovine pregnancy associated glycoprotein-1</topic><topic>Cattle - blood</topic><topic>Cattle - embryology</topic><topic>Cattle - metabolism</topic><topic>Dairy cow</topic><topic>Female</topic><topic>Fetal Death</topic><topic>Life sciences</topic><topic>Logistic Models</topic><topic>Médecine vétérinaire & santé animale</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - blood</topic><topic>Nitric Oxide - metabolism</topic><topic>Original</topic><topic>Pregnancy</topic><topic>Pregnancy associated glycoprotein</topic><topic>Pregnancy loss</topic><topic>Pregnancy Proteins - blood</topic><topic>Pregnancy Proteins - metabolism</topic><topic>Progesterone</topic><topic>Progesterone - metabolism</topic><topic>Sciences du vivant</topic><topic>Veterinary medicine & animal health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAREN, Aly</creatorcontrib><creatorcontrib>BAJCSY, Árpád Csaba</creatorcontrib><creatorcontrib>MINOIA, Rosa</creatorcontrib><creatorcontrib>KOVÁCS, Rezső</creatorcontrib><creatorcontrib>SOUSA, Noelita Melo DE</creatorcontrib><creatorcontrib>BECKERS, Jean-François</creatorcontrib><creatorcontrib>TIBOLD, János</creatorcontrib><creatorcontrib>MÁDL, István</creatorcontrib><creatorcontrib>SZENCI, Ottó</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Reproduction and Development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAREN, Aly</au><au>BAJCSY, Árpád Csaba</au><au>MINOIA, Rosa</au><au>KOVÁCS, Rezső</au><au>SOUSA, Noelita Melo DE</au><au>BECKERS, Jean-François</au><au>TIBOLD, János</au><au>MÁDL, István</au><au>SZENCI, Ottó</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of Progesterone, Bovine Pregnancy-Associated Glycoprotein-1 and Nitric Oxide with Late Embryonic and Early Fetal Mortalities in Dairy Cows</atitle><jtitle>Journal of Reproduction and Development</jtitle><addtitle>J. Reprod. Dev.</addtitle><date>2014</date><risdate>2014</risdate><volume>60</volume><issue>2</issue><spage>162</spage><epage>167</epage><pages>162-167</pages><issn>0916-8818</issn><issn>1348-4400</issn><eissn>1348-4400</eissn><abstract>The aim of the present study was to determine the relationship of progesterone (P4), bovine pregnancy-associated glycoprotein-1 (bPAG-1) and nitric oxide (NO) levels with late embryonic (LEM; day 28 to day 42) and early fetal mortalities (EFM; > day 42 to day 56) in dairy cows. Transrectal ultrasonography (6–8 MHz) was performed in 100 Holstein-Friesian cows at days 28, 42 and 56 after artificial insemination (AI; day 0) to diagnose pregnancy and to monitor the fate of the embryo. After ultrasound scanning of each cow, a milk sample was collected for assessment of P4 by an ELISA test and a blood sample was collected for assessment of bPAG-1, by using a double-antibody radioimmunoassay, and serum NO metabolites (nitrate + nitrite). Based on ultrasonographic examinations and bPAG-1-RIA, 41 of 100 inseminated cows were confirmed pregnant at day 28 after AI. Nine cows suffered of LEM, and 6 cows suffered of EFM and the overall pregnancy loss rate was 36.6% (15/41) between days 28 and 56 of pregnancy. By logistic regression analysis, there were no significant relationships between the level of P4 and bPAG-1 at day 28 after AI and the occurrence of LEM and EFM. Also, there were no significant relationships between the levels of P4 and bPAG-1 at day 42 and the occurrence of EFM. On the other hand, a significant relationship (P<0.05) was found between NO level at day 28 and the occurrence of LEM. In conclusion, measurement of the serum NO concentration at day 28 of pregnancy might help to predict the outcome of pregnancy by day 42 in dairy cows but further studies are needed to confirm this.</abstract><cop>Japan</cop><pub>THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT</pub><pmid>24531657</pmid><doi>10.1262/jrd.2013-033</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-8818 |
| ispartof | Journal of Reproduction and Development, 2014, Vol.60(2), pp.162-167 |
| issn | 0916-8818 1348-4400 1348-4400 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3999396 |
| source | J-STAGE Free; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Animals Aspartic Acid Endopeptidases - blood Aspartic Acid Endopeptidases - metabolism Bovine pregnancy associated glycoprotein-1 Cattle - blood Cattle - embryology Cattle - metabolism Dairy cow Female Fetal Death Life sciences Logistic Models Médecine vétérinaire & santé animale Nitric oxide Nitric Oxide - blood Nitric Oxide - metabolism Original Pregnancy Pregnancy associated glycoprotein Pregnancy loss Pregnancy Proteins - blood Pregnancy Proteins - metabolism Progesterone Progesterone - metabolism Sciences du vivant Veterinary medicine & animal health |
| title | Relationship of Progesterone, Bovine Pregnancy-Associated Glycoprotein-1 and Nitric Oxide with Late Embryonic and Early Fetal Mortalities in Dairy Cows |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T20%3A29%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_liege&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20of%20Progesterone,%20Bovine%20Pregnancy-Associated%20Glycoprotein-1%20and%20Nitric%20Oxide%20with%20Late%20Embryonic%20and%20Early%20Fetal%20Mortalities%20in%20Dairy%20Cows&rft.jtitle=Journal%20of%20Reproduction%20and%20Development&rft.au=KAREN,%20Aly&rft.date=2014&rft.volume=60&rft.issue=2&rft.spage=162&rft.epage=167&rft.pages=162-167&rft.issn=0916-8818&rft.eissn=1348-4400&rft_id=info:doi/10.1262/jrd.2013-033&rft_dat=%3Cpubmed_liege%3E24531657%3C/pubmed_liege%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/24531657&rfr_iscdi=true |