Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

Metabolic reprogramming is an important driver of tumor progression; however, the metabolic regulators of tumor cell motility and metastasis are not understood. Here, we show that tumors maintain energy production under nutrient deprivation through the function of HSP90 chaperones compartmentalized...

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Veröffentlicht in:	The Journal of clinical investigation 2013-07, Vol.123 (7), p.2907-2920
Hauptverfasser:	Caino, M Cecilia, Chae, Young Chan, Vaira, Valentina, Ferrero, Stefano, Nosotti, Mario, Martin, Nina M, Weeraratna, Ashani, O'Connell, Michael, Jernigan, Danielle, Fatatis, Alessandro, Languino, Lucia R, Bosari, Silvano, Altieri, Dario C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate Kinase - metabolism Animals Antineoplastic Agents - pharmacology Autophagy-Related Protein-1 Homolog Biomedical research Bone Neoplasms - metabolism Bone Neoplasms - secondary Cancer Cancer cells Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - secondary Cell adhesion & migration Cell growth Cell Line, Tumor Cell Movement Cytoskeleton Cytoskeleton - metabolism Experiments Female Gene Knockdown Techniques Guanidines - pharmacology Health aspects Hexokinase - metabolism HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kaplan-Meier Estimate Kinases Laboratory animals Lactams, Macrocyclic - pharmacology Liver Neoplasms, Experimental - metabolism Liver Neoplasms, Experimental - secondary Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Metastasis Mice Mice, SCID Microscopy Mitochondria Mitochondria - metabolism Mitochondrial Membranes - enzymology Motility Neoplasm Transplantation NIH 3T3 Cells Patients Phosphorylation Physiological aspects Protein folding Protein Processing, Post-Translational Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RNA, Small Interfering - genetics Stress (Physiology) Stress, Physiological Tumors
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