Pulmonary artery pressure, gender, menopause, and pregnancy in schistosomiasis-associated pulmonary hypertension
Schistosomiasis-associated pulmonary arterial hypertension (SPAH) is a major concern worldwide. However, the role of gender-specific contributing factors in SPAH is unknown. We investigated how systolic pulmonary artery pressure (SPAP) values and the presence of severe SPAP relate to gender, menopau...
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| Veröffentlicht in: | Arquivos brasileiros de cardiologia 2013-08, Vol.101 (2), p.154-159 |
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| creator | Armstrong, Anderson C Bandeira, Ângela M P Correia, Luis C L Melo, Humberto C O Silveira, Carlos A M Albuquerque, Eugênio Moraes, Jr, Jeová C Silva, Antônio M L Lima, João A C Sobral Filho, Dário C |
| description | Schistosomiasis-associated pulmonary arterial hypertension (SPAH) is a major concern worldwide. However, the role of gender-specific contributing factors in SPAH is unknown.
We investigated how systolic pulmonary artery pressure (SPAP) values and the presence of severe SPAP relate to gender, menopausal status, and pregnancy history in SPAH patients.
Seventy-nine patients diagnosed with SPAH from 2000 to 2009 were assessed and 66 were enrolled in the study. Information about age, menopausal status, pregnancy, echocardiography-derived SPAP, and invasive mean pulmonary artery pressure (mPAP) was collected from medical records. The relation between values of SPAP and mPAP and their agreement for severe disease were assessed. Regression models assessed the association of gender, menopausal status, and pregnancy history with SPAP values and the presence of severe SPAP.
Moderate correlation and good agreement for severe disease were found between mPAP and SPAP. Mean SPAP values were similar for men and women. A trend toward higher values of SPAP was found for non-menopausal women compared to men. Higher SPAP values were found for menopausal compared to non-menopausal women; the values were non-significant after adjustment for age. Pregnancy history had no association with SPAP. Menopause and positive pregnancy had no association with severe SPAP.
In SPAH patients, neither gender, nor menopausal status, nor pregnancy history showed independent correlation with SPAP values assessed by echocardiography. |
| doi_str_mv | 10.5935/abc.20130130 |
| format | Article |
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We investigated how systolic pulmonary artery pressure (SPAP) values and the presence of severe SPAP relate to gender, menopausal status, and pregnancy history in SPAH patients.
Seventy-nine patients diagnosed with SPAH from 2000 to 2009 were assessed and 66 were enrolled in the study. Information about age, menopausal status, pregnancy, echocardiography-derived SPAP, and invasive mean pulmonary artery pressure (mPAP) was collected from medical records. The relation between values of SPAP and mPAP and their agreement for severe disease were assessed. Regression models assessed the association of gender, menopausal status, and pregnancy history with SPAP values and the presence of severe SPAP.
Moderate correlation and good agreement for severe disease were found between mPAP and SPAP. Mean SPAP values were similar for men and women. A trend toward higher values of SPAP was found for non-menopausal women compared to men. Higher SPAP values were found for menopausal compared to non-menopausal women; the values were non-significant after adjustment for age. Pregnancy history had no association with SPAP. Menopause and positive pregnancy had no association with severe SPAP.
In SPAH patients, neither gender, nor menopausal status, nor pregnancy history showed independent correlation with SPAP values assessed by echocardiography.</description><identifier>ISSN: 0066-782X</identifier><identifier>EISSN: 1678-4170</identifier><identifier>DOI: 10.5935/abc.20130130</identifier><identifier>PMID: 23821406</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Cardiologia</publisher><subject>Adult ; Arterial Pressure - physiology ; Echocardiography, Doppler ; Familial Primary Pulmonary Hypertension ; Female ; Humans ; Hypertension, Pulmonary - etiology ; Hypertension, Pulmonary - physiopathology ; Male ; Menopause - physiology ; Middle Aged ; Original ; Pregnancy ; Pulmonary Artery - physiopathology ; Reference Values ; Reproductive History ; Schistosomiasis - complications ; Schistosomiasis - physiopathology ; Severity of Illness Index ; Sex Factors</subject><ispartof>Arquivos brasileiros de cardiologia, 2013-08, Vol.101 (2), p.154-159</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998155/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998155/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23821406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Armstrong, Anderson C</creatorcontrib><creatorcontrib>Bandeira, Ângela M P</creatorcontrib><creatorcontrib>Correia, Luis C L</creatorcontrib><creatorcontrib>Melo, Humberto C O</creatorcontrib><creatorcontrib>Silveira, Carlos A M</creatorcontrib><creatorcontrib>Albuquerque, Eugênio</creatorcontrib><creatorcontrib>Moraes, Jr, Jeová C</creatorcontrib><creatorcontrib>Silva, Antônio M L</creatorcontrib><creatorcontrib>Lima, João A C</creatorcontrib><creatorcontrib>Sobral Filho, Dário C</creatorcontrib><title>Pulmonary artery pressure, gender, menopause, and pregnancy in schistosomiasis-associated pulmonary hypertension</title><title>Arquivos brasileiros de cardiologia</title><addtitle>Arq Bras Cardiol</addtitle><description>Schistosomiasis-associated pulmonary arterial hypertension (SPAH) is a major concern worldwide. However, the role of gender-specific contributing factors in SPAH is unknown.
We investigated how systolic pulmonary artery pressure (SPAP) values and the presence of severe SPAP relate to gender, menopausal status, and pregnancy history in SPAH patients.
Seventy-nine patients diagnosed with SPAH from 2000 to 2009 were assessed and 66 were enrolled in the study. Information about age, menopausal status, pregnancy, echocardiography-derived SPAP, and invasive mean pulmonary artery pressure (mPAP) was collected from medical records. The relation between values of SPAP and mPAP and their agreement for severe disease were assessed. Regression models assessed the association of gender, menopausal status, and pregnancy history with SPAP values and the presence of severe SPAP.
Moderate correlation and good agreement for severe disease were found between mPAP and SPAP. Mean SPAP values were similar for men and women. A trend toward higher values of SPAP was found for non-menopausal women compared to men. Higher SPAP values were found for menopausal compared to non-menopausal women; the values were non-significant after adjustment for age. Pregnancy history had no association with SPAP. Menopause and positive pregnancy had no association with severe SPAP.
In SPAH patients, neither gender, nor menopausal status, nor pregnancy history showed independent correlation with SPAP values assessed by echocardiography.</description><subject>Adult</subject><subject>Arterial Pressure - physiology</subject><subject>Echocardiography, Doppler</subject><subject>Familial Primary Pulmonary Hypertension</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - etiology</subject><subject>Hypertension, Pulmonary - physiopathology</subject><subject>Male</subject><subject>Menopause - physiology</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Pregnancy</subject><subject>Pulmonary Artery - physiopathology</subject><subject>Reference Values</subject><subject>Reproductive History</subject><subject>Schistosomiasis - complications</subject><subject>Schistosomiasis - physiopathology</subject><subject>Severity of Illness Index</subject><subject>Sex Factors</subject><issn>0066-782X</issn><issn>1678-4170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1r3DAQxUVpabbb3nouPvawTvRp2ZdCCf2CQHpIoDcxluRdFVtyNXZg__tqSbK0MDDw5sd7A4-Q94xeqk6oK-jtJadMnOYF2bBGt7Vkmr4kG0qbptYt_3VB3iD-ppRzLdRrcsFFy5mkzYbMP9dxShHysYK8-LLm7BHX7HfV3kfn866afEwzrFgkiO4E7CNEe6xCrNAeAi4J0xQAA9aAmGyAxRfu7Hw4zr6YRwwpviWvBhjRv3vaW3L_9cvd9ff65vbbj-vPN7Xlmi21VZQx6qjkvbYdF056pYSDgWkBtOP9YNUgpXSKdUVwdlC0Bd71oLWVjost-fToO6_95J31cckwmjmHqbxkEgTz_yWGg9mnByO6rmUla0s-Phnk9Gf1uJgpoPXjCNGnFQ2TUnWsoaIp6O4RtTkhZj-cYxg1p5JMKck8l1TwD_--doafWxF_ATD_kVI</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Armstrong, Anderson C</creator><creator>Bandeira, Ângela M P</creator><creator>Correia, Luis C L</creator><creator>Melo, Humberto C O</creator><creator>Silveira, Carlos A M</creator><creator>Albuquerque, Eugênio</creator><creator>Moraes, Jr, Jeová C</creator><creator>Silva, Antônio M L</creator><creator>Lima, João A C</creator><creator>Sobral Filho, Dário C</creator><general>Sociedade Brasileira de Cardiologia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130801</creationdate><title>Pulmonary artery pressure, gender, menopause, and pregnancy in schistosomiasis-associated pulmonary hypertension</title><author>Armstrong, Anderson C ; Bandeira, Ângela M P ; Correia, Luis C L ; Melo, Humberto C O ; Silveira, Carlos A M ; Albuquerque, Eugênio ; Moraes, Jr, Jeová C ; Silva, Antônio M L ; Lima, João A C ; Sobral Filho, Dário C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-c50110d042b7c923d4e553daf173a092bfc5f444d5193a0dcf508a29ba77c4d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Arterial Pressure - physiology</topic><topic>Echocardiography, Doppler</topic><topic>Familial Primary Pulmonary Hypertension</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - etiology</topic><topic>Hypertension, Pulmonary - physiopathology</topic><topic>Male</topic><topic>Menopause - physiology</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Pregnancy</topic><topic>Pulmonary Artery - physiopathology</topic><topic>Reference Values</topic><topic>Reproductive History</topic><topic>Schistosomiasis - complications</topic><topic>Schistosomiasis - physiopathology</topic><topic>Severity of Illness Index</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Armstrong, Anderson C</creatorcontrib><creatorcontrib>Bandeira, Ângela M P</creatorcontrib><creatorcontrib>Correia, Luis C L</creatorcontrib><creatorcontrib>Melo, Humberto C O</creatorcontrib><creatorcontrib>Silveira, Carlos A M</creatorcontrib><creatorcontrib>Albuquerque, Eugênio</creatorcontrib><creatorcontrib>Moraes, Jr, Jeová C</creatorcontrib><creatorcontrib>Silva, Antônio M L</creatorcontrib><creatorcontrib>Lima, João A C</creatorcontrib><creatorcontrib>Sobral Filho, Dário C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arquivos brasileiros de cardiologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Armstrong, Anderson C</au><au>Bandeira, Ângela M P</au><au>Correia, Luis C L</au><au>Melo, Humberto C O</au><au>Silveira, Carlos A M</au><au>Albuquerque, Eugênio</au><au>Moraes, Jr, Jeová C</au><au>Silva, Antônio M L</au><au>Lima, João A C</au><au>Sobral Filho, Dário C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary artery pressure, gender, menopause, and pregnancy in schistosomiasis-associated pulmonary hypertension</atitle><jtitle>Arquivos brasileiros de cardiologia</jtitle><addtitle>Arq Bras Cardiol</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>101</volume><issue>2</issue><spage>154</spage><epage>159</epage><pages>154-159</pages><issn>0066-782X</issn><eissn>1678-4170</eissn><abstract>Schistosomiasis-associated pulmonary arterial hypertension (SPAH) is a major concern worldwide. However, the role of gender-specific contributing factors in SPAH is unknown.
We investigated how systolic pulmonary artery pressure (SPAP) values and the presence of severe SPAP relate to gender, menopausal status, and pregnancy history in SPAH patients.
Seventy-nine patients diagnosed with SPAH from 2000 to 2009 were assessed and 66 were enrolled in the study. Information about age, menopausal status, pregnancy, echocardiography-derived SPAP, and invasive mean pulmonary artery pressure (mPAP) was collected from medical records. The relation between values of SPAP and mPAP and their agreement for severe disease were assessed. Regression models assessed the association of gender, menopausal status, and pregnancy history with SPAP values and the presence of severe SPAP.
Moderate correlation and good agreement for severe disease were found between mPAP and SPAP. Mean SPAP values were similar for men and women. A trend toward higher values of SPAP was found for non-menopausal women compared to men. Higher SPAP values were found for menopausal compared to non-menopausal women; the values were non-significant after adjustment for age. Pregnancy history had no association with SPAP. Menopause and positive pregnancy had no association with severe SPAP.
In SPAH patients, neither gender, nor menopausal status, nor pregnancy history showed independent correlation with SPAP values assessed by echocardiography.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Cardiologia</pub><pmid>23821406</pmid><doi>10.5935/abc.20130130</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Arquivos brasileiros de cardiologia, 2013-08, Vol.101 (2), p.154-159 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Arterial Pressure - physiology Echocardiography, Doppler Familial Primary Pulmonary Hypertension Female Humans Hypertension, Pulmonary - etiology Hypertension, Pulmonary - physiopathology Male Menopause - physiology Middle Aged Original Pregnancy Pulmonary Artery - physiopathology Reference Values Reproductive History Schistosomiasis - complications Schistosomiasis - physiopathology Severity of Illness Index Sex Factors |
| title | Pulmonary artery pressure, gender, menopause, and pregnancy in schistosomiasis-associated pulmonary hypertension |
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