Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism

Large individual differences in susceptibility to arsenic-induced diseases are well-documented and frequently associated with different patterns of arsenic metabolism. In this context, the role of the gut microbiome in directly metabolizing arsenic and triggering systemic responses in diverse organs...

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Veröffentlicht in:	Chemical research in toxicology 2014-02, Vol.27 (2), p.172-174
Hauptverfasser:	Lu, Kun, Mahbub, Ridwan, Cable, Peter Hans, Ru, Hongyu, Parry, Nicola M. A, Bodnar, Wanda M, Wishnok, John S, Styblo, Miroslav, Swenberg, James A, Fox, James G, Tannenbaum, Steven R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenic - pharmacokinetics Biotransformation Chromatography, High Pressure Liquid Environmental Pollutants - pharmacokinetics Gastrointestinal Tract - metabolism Gastrointestinal Tract - microbiology Interleukin-10 - genetics Mass Spectrometry Mice Mice, Knockout Microbiota Phenotype Rapid Report RNA, Ribosomal, 16S - genetics
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