Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1

Mammalian epithelial cells are coated with a multifunctional surface glycocalyx (GCX). On vascular endothelial cells (EC), intact GCX is atheroprotective. It is degraded in many vascular diseases. GCX heparan sulfate (HS) is essential for healthy flow-induced EC nitric oxide (NO) release, elongation...

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Veröffentlicht in:	Integrative biology (Cambridge) 2014-01, Vol.6 (3), p.338-347
Hauptverfasser:	Ebong, Eno E, Lopez-Quintero, Sandra V, Rizzo, Victor, Spray, David C, Tarbell, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomechanical Phenomena biomechanics Cattle Cell Shape - physiology Cells, Cultured chronic exposure cytoskeleton endothelial cells Endothelial Cells - metabolism endothelial nitric oxide synthase Enzyme Activation epithelial cells Gene Knockdown Techniques Glycocalyx - metabolism Glypicans - antagonists & inhibitors Glypicans - genetics Glypicans - metabolism heparan sulfate heparin lyase Heparitin Sulfate - metabolism Hydrodynamics mammals mechanotransduction Mechanotransduction, Cellular - physiology nitric oxide Nitric Oxide Synthase Type III - metabolism RNA, Small Interfering - genetics shear stress Stress, Mechanical Syndecan-1 - antagonists & inhibitors Syndecan-1 - genetics Syndecan-1 - metabolism syndecans vascular diseases
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