Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma

Mantle cell lymphoma (MCL) is considered one of the most challenging lymphoma, with limited responses to current therapies. Acadesine, a nucleoside analogue has shown antitumoral effects in different preclinical cancer models as well as in a recent phase I/II clinical trial conducted in patients wit...

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Veröffentlicht in:	Oncotarget 2014-02, Vol.5 (3), p.726-739
Hauptverfasser:	Montraveta, Arnau, Xargay-Torrent, Sílvia, López-Guerra, Mónica, Rosich, Laia, Pérez-Galán, Patricia, Salaverria, Itziar, Beà, Silvia, Kalko, Susana G, de Frias, Mercè, Campàs, Clara, Roué, Gaël, Colomer, Dolors
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoimidazole Carboxamide - administration & dosage Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology Animals Antibodies, Monoclonal, Murine-Derived - administration & dosage Antibodies, Monoclonal, Murine-Derived - immunology Antibodies, Monoclonal, Murine-Derived - pharmacology Antigens, CD20 - immunology Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Cell Line, Tumor Cohort Studies Disease Models, Animal Drug Synergism Female Humans Lymphoma, Mantle-Cell - drug therapy Mice Mice, SCID Random Allocation Research Paper Ribonucleosides - administration & dosage Ribonucleosides - pharmacology Rituximab Xenograft Model Antitumor Assays
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