Noninvasive pressure difference mapping derived from 4D flow MRI in patients with unrepaired and repaired aortic coarctation
To develop a method for computing and visualizing pressure differences derived from time-resolved velocity-encoded three-dimensional phase-contrast magnetic resonance imaging (4D flow MRI) and to compare pressure difference maps of patients with unrepaired and repaired aortic coarctation to young he...
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Veröffentlicht in: | Cardiovascular diagnosis and therapy 2014-04, Vol.4 (2), p.97-103 |
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creator | Rengier, Fabian Delles, Michael Eichhorn, Joachim Azad, Yoo-Jin von Tengg-Kobligk, Hendrik Ley-Zaporozhan, Julia Dillmann, Rüdiger Kauczor, Hans-Ulrich Unterhinninghofen, Roland Ley, Sebastian |
description | To develop a method for computing and visualizing pressure differences derived from time-resolved velocity-encoded three-dimensional phase-contrast magnetic resonance imaging (4D flow MRI) and to compare pressure difference maps of patients with unrepaired and repaired aortic coarctation to young healthy volunteers.
4D flow MRI data of four patients with aortic coarctation either before or after repair (mean age 17 years, age range 3-28, one female, three males) and four young healthy volunteers without history of cardiovascular disease (mean age 24 years, age range 20-27, one female, three males) was acquired using a 1.5-T clinical MR scanner. Image analysis was performed with in-house developed image processing software. Relative pressures were computed based on the Navier-Stokes equation.
A standardized method for intuitive visualization of pressure difference maps was developed and successfully applied to all included patients and volunteers. Young healthy volunteers exhibited smooth and regular distribution of relative pressures in the thoracic aorta at mid systole with very similar distribution in all analyzed volunteers. Patients demonstrated disturbed pressures compared to volunteers. Changes included a pressure drop at the aortic isthmus in all patients, increased relative pressures in the aortic arch in patients with residual narrowing after repair, and increased relative pressures in the descending aorta in a patient after patch aortoplasty.
Pressure difference maps derived from 4D flow MRI can depict alterations of spatial pressure distribution in patients with repaired and unrepaired aortic coarctation. The technique might allow identifying pathophysiological conditions underlying complications after aortic coarctation repair. |
doi_str_mv | 10.3978/j.issn.2223-3652.2014.03.03 |
format | Article |
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4D flow MRI data of four patients with aortic coarctation either before or after repair (mean age 17 years, age range 3-28, one female, three males) and four young healthy volunteers without history of cardiovascular disease (mean age 24 years, age range 20-27, one female, three males) was acquired using a 1.5-T clinical MR scanner. Image analysis was performed with in-house developed image processing software. Relative pressures were computed based on the Navier-Stokes equation.
A standardized method for intuitive visualization of pressure difference maps was developed and successfully applied to all included patients and volunteers. Young healthy volunteers exhibited smooth and regular distribution of relative pressures in the thoracic aorta at mid systole with very similar distribution in all analyzed volunteers. Patients demonstrated disturbed pressures compared to volunteers. Changes included a pressure drop at the aortic isthmus in all patients, increased relative pressures in the aortic arch in patients with residual narrowing after repair, and increased relative pressures in the descending aorta in a patient after patch aortoplasty.
Pressure difference maps derived from 4D flow MRI can depict alterations of spatial pressure distribution in patients with repaired and unrepaired aortic coarctation. The technique might allow identifying pathophysiological conditions underlying complications after aortic coarctation repair.</description><identifier>ISSN: 2223-3652</identifier><identifier>EISSN: 2223-3660</identifier><identifier>DOI: 10.3978/j.issn.2223-3652.2014.03.03</identifier><identifier>PMID: 24834408</identifier><language>eng</language><publisher>China (Republic : 1949- ): AME Publishing Company</publisher><subject>Original</subject><ispartof>Cardiovascular diagnosis and therapy, 2014-04, Vol.4 (2), p.97-103</ispartof><rights>2014 Cardiovascular Diagnosis and Therapy. All rights reserved. 2014 Cardiovascular Diagnosis and Therapy.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996241/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996241/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24834408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rengier, Fabian</creatorcontrib><creatorcontrib>Delles, Michael</creatorcontrib><creatorcontrib>Eichhorn, Joachim</creatorcontrib><creatorcontrib>Azad, Yoo-Jin</creatorcontrib><creatorcontrib>von Tengg-Kobligk, Hendrik</creatorcontrib><creatorcontrib>Ley-Zaporozhan, Julia</creatorcontrib><creatorcontrib>Dillmann, Rüdiger</creatorcontrib><creatorcontrib>Kauczor, Hans-Ulrich</creatorcontrib><creatorcontrib>Unterhinninghofen, Roland</creatorcontrib><creatorcontrib>Ley, Sebastian</creatorcontrib><title>Noninvasive pressure difference mapping derived from 4D flow MRI in patients with unrepaired and repaired aortic coarctation</title><title>Cardiovascular diagnosis and therapy</title><addtitle>Cardiovasc Diagn Ther</addtitle><description>To develop a method for computing and visualizing pressure differences derived from time-resolved velocity-encoded three-dimensional phase-contrast magnetic resonance imaging (4D flow MRI) and to compare pressure difference maps of patients with unrepaired and repaired aortic coarctation to young healthy volunteers.
4D flow MRI data of four patients with aortic coarctation either before or after repair (mean age 17 years, age range 3-28, one female, three males) and four young healthy volunteers without history of cardiovascular disease (mean age 24 years, age range 20-27, one female, three males) was acquired using a 1.5-T clinical MR scanner. Image analysis was performed with in-house developed image processing software. Relative pressures were computed based on the Navier-Stokes equation.
A standardized method for intuitive visualization of pressure difference maps was developed and successfully applied to all included patients and volunteers. Young healthy volunteers exhibited smooth and regular distribution of relative pressures in the thoracic aorta at mid systole with very similar distribution in all analyzed volunteers. Patients demonstrated disturbed pressures compared to volunteers. Changes included a pressure drop at the aortic isthmus in all patients, increased relative pressures in the aortic arch in patients with residual narrowing after repair, and increased relative pressures in the descending aorta in a patient after patch aortoplasty.
Pressure difference maps derived from 4D flow MRI can depict alterations of spatial pressure distribution in patients with repaired and unrepaired aortic coarctation. The technique might allow identifying pathophysiological conditions underlying complications after aortic coarctation repair.</description><subject>Original</subject><issn>2223-3652</issn><issn>2223-3660</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpVUNtKAzEQDaJYqf0FCfjcNfdmXwSpt0JVEH1eskm2TekmS7JtEfx4A9aqw8DczjnMDACXGBW0nMirVeFS8gUhhI6p4KQgCLMC0exH4GzfFuj4kHMyAKOUViib5FgKcgoGhEnKGJJn4PM5eOe3KrmthV20KW2ihcY1jY3Wawtb1XXOL6CxMUMMbGJoIbuFzTrs4NPrDDoPO9U76_sEd65fwo2PtlMuZrDyBv4WIfZOQx1U1H1mBH8OThq1Tna0j0Pwfn_3Nn0cz18eZtOb-bjDpejHhClCjeYSSyw4M8YSXCuqFVeNzBcijrnhknGqiZJW1JOSIk14zZistRF0CK6_dbtN3Vqj865RrasuulbFjyooV_2feLesFmFb0bIUhOEscPFX4MD8-SP9AvspfEE</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Rengier, Fabian</creator><creator>Delles, Michael</creator><creator>Eichhorn, Joachim</creator><creator>Azad, Yoo-Jin</creator><creator>von Tengg-Kobligk, Hendrik</creator><creator>Ley-Zaporozhan, Julia</creator><creator>Dillmann, Rüdiger</creator><creator>Kauczor, Hans-Ulrich</creator><creator>Unterhinninghofen, Roland</creator><creator>Ley, Sebastian</creator><general>AME Publishing Company</general><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>201404</creationdate><title>Noninvasive pressure difference mapping derived from 4D flow MRI in patients with unrepaired and repaired aortic coarctation</title><author>Rengier, Fabian ; Delles, Michael ; Eichhorn, Joachim ; Azad, Yoo-Jin ; von Tengg-Kobligk, Hendrik ; Ley-Zaporozhan, Julia ; Dillmann, Rüdiger ; Kauczor, Hans-Ulrich ; Unterhinninghofen, Roland ; Ley, Sebastian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p196t-24a23dc58181654dde21ba3ca5af83650515d58453c2a8e6b7930c25b448bcd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Rengier, Fabian</creatorcontrib><creatorcontrib>Delles, Michael</creatorcontrib><creatorcontrib>Eichhorn, Joachim</creatorcontrib><creatorcontrib>Azad, Yoo-Jin</creatorcontrib><creatorcontrib>von Tengg-Kobligk, Hendrik</creatorcontrib><creatorcontrib>Ley-Zaporozhan, Julia</creatorcontrib><creatorcontrib>Dillmann, Rüdiger</creatorcontrib><creatorcontrib>Kauczor, Hans-Ulrich</creatorcontrib><creatorcontrib>Unterhinninghofen, Roland</creatorcontrib><creatorcontrib>Ley, Sebastian</creatorcontrib><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cardiovascular diagnosis and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rengier, Fabian</au><au>Delles, Michael</au><au>Eichhorn, Joachim</au><au>Azad, Yoo-Jin</au><au>von Tengg-Kobligk, Hendrik</au><au>Ley-Zaporozhan, Julia</au><au>Dillmann, Rüdiger</au><au>Kauczor, Hans-Ulrich</au><au>Unterhinninghofen, Roland</au><au>Ley, Sebastian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noninvasive pressure difference mapping derived from 4D flow MRI in patients with unrepaired and repaired aortic coarctation</atitle><jtitle>Cardiovascular diagnosis and therapy</jtitle><addtitle>Cardiovasc Diagn Ther</addtitle><date>2014-04</date><risdate>2014</risdate><volume>4</volume><issue>2</issue><spage>97</spage><epage>103</epage><pages>97-103</pages><issn>2223-3652</issn><eissn>2223-3660</eissn><abstract>To develop a method for computing and visualizing pressure differences derived from time-resolved velocity-encoded three-dimensional phase-contrast magnetic resonance imaging (4D flow MRI) and to compare pressure difference maps of patients with unrepaired and repaired aortic coarctation to young healthy volunteers.
4D flow MRI data of four patients with aortic coarctation either before or after repair (mean age 17 years, age range 3-28, one female, three males) and four young healthy volunteers without history of cardiovascular disease (mean age 24 years, age range 20-27, one female, three males) was acquired using a 1.5-T clinical MR scanner. Image analysis was performed with in-house developed image processing software. Relative pressures were computed based on the Navier-Stokes equation.
A standardized method for intuitive visualization of pressure difference maps was developed and successfully applied to all included patients and volunteers. Young healthy volunteers exhibited smooth and regular distribution of relative pressures in the thoracic aorta at mid systole with very similar distribution in all analyzed volunteers. Patients demonstrated disturbed pressures compared to volunteers. Changes included a pressure drop at the aortic isthmus in all patients, increased relative pressures in the aortic arch in patients with residual narrowing after repair, and increased relative pressures in the descending aorta in a patient after patch aortoplasty.
Pressure difference maps derived from 4D flow MRI can depict alterations of spatial pressure distribution in patients with repaired and unrepaired aortic coarctation. The technique might allow identifying pathophysiological conditions underlying complications after aortic coarctation repair.</abstract><cop>China (Republic : 1949- )</cop><pub>AME Publishing Company</pub><pmid>24834408</pmid><doi>10.3978/j.issn.2223-3652.2014.03.03</doi><tpages>7</tpages></addata></record> |
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title | Noninvasive pressure difference mapping derived from 4D flow MRI in patients with unrepaired and repaired aortic coarctation |
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