Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation

Bisphosphonates are an important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Recent studies have shown that nitrogen-containing bisphosphonates induced apoptosis in rabbit osteoclasts and prevented prenylated small GTPase. However, whether bisphosphonates inhibit...

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Veröffentlicht in:	Journal of biomedical science 2014-02, Vol.21 (1), p.10-10, Article 10
Hauptverfasser:	Tsubaki, Masanobu, Komai, Makiko, Itoh, Tatsuki, Imano, Motohiro, Sakamoto, Kotaro, Shimaoka, Hirotaka, Takeda, Tomoya, Ogawa, Naoki, Mashimo, Kenji, Fujiwara, Daiichiro, Mukai, Junji, Sakaguchi, Katsuhiko, Satou, Takao, Nishida, Shozo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alendronate - administration & dosage Animals Apoptosis Apoptosis - drug effects Bone diseases Bone Diseases, Metabolic - drug therapy Bone Diseases, Metabolic - metabolism Bone Diseases, Metabolic - pathology Cancer Cellular signal transduction Diphosphonates - administration & dosage Diphosphonates - chemistry Humans Imidazoles - administration & dosage Kinases Ligands Macrophage colony stimulating factor Macrophage Colony-Stimulating Factor - metabolism Macrophages Macrophages - cytology Macrophages - drug effects MAP Kinase Signaling System - genetics Medical research Medicine, Experimental Mice Mitogens Nitrogen - chemistry Oncogene Protein v-akt - metabolism Osteoclasts - drug effects Osteoporosis Pharmacy Phosphates Phosphonates Polyisoprenyl Phosphates - biosynthesis Protein kinases Proteins RANK Ligand - antagonists & inhibitors Studies
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