Adverse fibrosis in the aging heart depends on signaling between myeloid and mesenchymal cells; role of inflammatory fibroblasts

Abstract Aging has been associated with adverse fibrosis. Here we formulate a new hypothesis and present new evidence that unresponsiveness of mesenchymal stem cells (MSC) and fibroblasts to transforming growth factor beta (TGF-β), due to reduced expression of TGF-β receptor I (TβRI), provides a fou...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2014-05, Vol.70, p.56-63
Hauptverfasser:	Cieslik, Katarzyna A, Trial, JoAnn, Crawford, Jeffrey R, Taffet, George E, Entman, Mark L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Aging - pathology Cardiovascular Cell Differentiation Collagen - genetics Collagen - metabolism Fibroblasts - metabolism Fibroblasts - pathology Fibrosis - metabolism Fibrosis - pathology Fibrosis - physiopathology Gene Expression Regulation Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - pathology Monocytes - metabolism Monocytes - pathology Myocardium - metabolism Myocardium - pathology Nanog Homeobox Protein Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - metabolism Signal Transduction T-Lymphocytes - metabolism T-Lymphocytes - pathology Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism
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