Antibiotic exposure in the first two years of life and development of asthma and other allergic diseases by 7.5 yr: A dose‐dependent relationship
Background Antibiotic use in infancy disrupts gut microflora during a critical period for immune system development. It is hypothesized that this could predispose to the development of allergic diseases. We investigated the associations of antibiotic use in the first 2 yr of life with the developmen...
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| Veröffentlicht in: | Pediatric allergy and immunology 2013-12, Vol.24 (8), p.762-771 |
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| container_title | Pediatric allergy and immunology |
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| creator | Hoskin‐Parr, Lauren Teyhan, Alison Blocker, Ariel Henderson, A. J. W. |
| description | Background
Antibiotic use in infancy disrupts gut microflora during a critical period for immune system development. It is hypothesized that this could predispose to the development of allergic diseases. We investigated the associations of antibiotic use in the first 2 yr of life with the development of asthma, eczema or hay fever by age 7.5 yr in a longitudinal birth cohort.
Methods
Subjects were 4952 children from the Avon Longitudinal Study of Parents and Children (ALSPAC). Child antibiotic use and asthma, eczema and hay fever symptoms were maternally reported. Atopy was assessed by skin prick tests at age 7.5 yr. The total number of antibiotic courses was considered as the main exposure. Data were analysed using multivariate logistic regression.
Results
Children reported to have taken antibiotics during infancy (0–2 yr) were more likely to have asthma at 7.5 yr (OR 1.75, 95% CI 1.40–2.17), and the odds (OR, [95% CI]) increased with greater numbers of courses: once 1.11 [0.84–1.48]; twice 1.50 [1.14–1.98]; three times 1.79 [1.34–2.40]; four times or more 2.82 [2.19–3.63]. Increased antibiotic use was also associated with higher odds of eczema and hay fever but not atopy. The effect appeared to be associated with cumulative rather than a critical period of exposure during the first 2 yr.
Conclusions
A robust and dose‐dependent association was found between antibiotic use in the first 2 yr of life and asthma at age 7.5 yr but did not appear to be mediated through an association with atopy. |
| doi_str_mv | 10.1111/pai.12153 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3995010</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1477557811</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5423-cdbfafe105eba9e6ca40df0cf8d80a2d2872ad1131cb054ccb882c75d67ba2133</originalsourceid><addsrcrecordid>eNqNks1qFTEUx4Mo9np14QtIwI0u5jYfk8mMi8Kl-FEo6ELXIZOc6U3JTMZkpnV2PoLgG_ok5vbWooJgNoGcX345OfwRekrJhuZ1PGq3oYwKfg-tKG-aghNe30cr0hBRVFTII_QopUtCqOQVfYiOWMmapqzkCn3fDpNrXZicwfBlDGmOgN2Apx3gzsU04ek64AV0TDh02LsOsB4stnAFPow9DNP-XKdp1-ubSshXI9beQ7zIUusS6AQJtwuWG4GX-ApvsQ0Jfnz9ZmGEwe4dEbyeXBjSzo2P0YNO-wRPbvc1-vTm9cfTd8X5-7dnp9vzwoiS8cLYttMdUCKg1Q1URpfEdsR0ta2JZpbVkmlLKaemJaI0pq1rZqSwlWw1o5yv0cnBO85tD9bkPqL2aoyu13FRQTv1Z2VwO3URrlQesSCUZMGLW0EMn2dIk-pdMuC9HiDMSdGyYRWpCOf_gUophKxzu2v0_C_0MsxxyJPIVCVlJUSzf_vlgTIxpBShu-ubErVPhcqpUDepyOyz3z96R_6KQQaOD8C187D826Q-bM8Oyp90Z8S9</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1467765590</pqid></control><display><type>article</type><title>Antibiotic exposure in the first two years of life and development of asthma and other allergic diseases by 7.5 yr: A dose‐dependent relationship</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Hoskin‐Parr, Lauren ; Teyhan, Alison ; Blocker, Ariel ; Henderson, A. J. W.</creator><creatorcontrib>Hoskin‐Parr, Lauren ; Teyhan, Alison ; Blocker, Ariel ; Henderson, A. J. W.</creatorcontrib><description>Background
Antibiotic use in infancy disrupts gut microflora during a critical period for immune system development. It is hypothesized that this could predispose to the development of allergic diseases. We investigated the associations of antibiotic use in the first 2 yr of life with the development of asthma, eczema or hay fever by age 7.5 yr in a longitudinal birth cohort.
Methods
Subjects were 4952 children from the Avon Longitudinal Study of Parents and Children (ALSPAC). Child antibiotic use and asthma, eczema and hay fever symptoms were maternally reported. Atopy was assessed by skin prick tests at age 7.5 yr. The total number of antibiotic courses was considered as the main exposure. Data were analysed using multivariate logistic regression.
Results
Children reported to have taken antibiotics during infancy (0–2 yr) were more likely to have asthma at 7.5 yr (OR 1.75, 95% CI 1.40–2.17), and the odds (OR, [95% CI]) increased with greater numbers of courses: once 1.11 [0.84–1.48]; twice 1.50 [1.14–1.98]; three times 1.79 [1.34–2.40]; four times or more 2.82 [2.19–3.63]. Increased antibiotic use was also associated with higher odds of eczema and hay fever but not atopy. The effect appeared to be associated with cumulative rather than a critical period of exposure during the first 2 yr.
Conclusions
A robust and dose‐dependent association was found between antibiotic use in the first 2 yr of life and asthma at age 7.5 yr but did not appear to be mediated through an association with atopy.</description><identifier>ISSN: 0905-6157</identifier><identifier>EISSN: 1399-3038</identifier><identifier>DOI: 10.1111/pai.12153</identifier><identifier>PMID: 24299467</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Age Factors ; Allergies ; Anti-Bacterial Agents - immunology ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Asthma - immunology ; atopy ; Avon Longitudinal Study of Parents and Children ; Child ; childhood asthma ; Cohort Studies ; Dose-Response Relationship, Immunologic ; eczema ; Eczema - immunology ; Epidemiology ; Female ; hay fever ; Humans ; Infant ; Infant, Newborn ; Longitudinal Studies ; Male ; Original ; Pediatrics ; Risk ; Skin Tests ; wheeze</subject><ispartof>Pediatric allergy and immunology, 2013-12, Vol.24 (8), p.762-771</ispartof><rights>2013 The Authors. Published by John Wiley & Sons Ltd.</rights><rights>2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons A/S</rights><rights>2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5423-cdbfafe105eba9e6ca40df0cf8d80a2d2872ad1131cb054ccb882c75d67ba2133</citedby><cites>FETCH-LOGICAL-c5423-cdbfafe105eba9e6ca40df0cf8d80a2d2872ad1131cb054ccb882c75d67ba2133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpai.12153$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpai.12153$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24299467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoskin‐Parr, Lauren</creatorcontrib><creatorcontrib>Teyhan, Alison</creatorcontrib><creatorcontrib>Blocker, Ariel</creatorcontrib><creatorcontrib>Henderson, A. J. W.</creatorcontrib><title>Antibiotic exposure in the first two years of life and development of asthma and other allergic diseases by 7.5 yr: A dose‐dependent relationship</title><title>Pediatric allergy and immunology</title><addtitle>Pediatr Allergy Immunol</addtitle><description>Background
Antibiotic use in infancy disrupts gut microflora during a critical period for immune system development. It is hypothesized that this could predispose to the development of allergic diseases. We investigated the associations of antibiotic use in the first 2 yr of life with the development of asthma, eczema or hay fever by age 7.5 yr in a longitudinal birth cohort.
Methods
Subjects were 4952 children from the Avon Longitudinal Study of Parents and Children (ALSPAC). Child antibiotic use and asthma, eczema and hay fever symptoms were maternally reported. Atopy was assessed by skin prick tests at age 7.5 yr. The total number of antibiotic courses was considered as the main exposure. Data were analysed using multivariate logistic regression.
Results
Children reported to have taken antibiotics during infancy (0–2 yr) were more likely to have asthma at 7.5 yr (OR 1.75, 95% CI 1.40–2.17), and the odds (OR, [95% CI]) increased with greater numbers of courses: once 1.11 [0.84–1.48]; twice 1.50 [1.14–1.98]; three times 1.79 [1.34–2.40]; four times or more 2.82 [2.19–3.63]. Increased antibiotic use was also associated with higher odds of eczema and hay fever but not atopy. The effect appeared to be associated with cumulative rather than a critical period of exposure during the first 2 yr.
Conclusions
A robust and dose‐dependent association was found between antibiotic use in the first 2 yr of life and asthma at age 7.5 yr but did not appear to be mediated through an association with atopy.</description><subject>Age Factors</subject><subject>Allergies</subject><subject>Anti-Bacterial Agents - immunology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Asthma - immunology</subject><subject>atopy</subject><subject>Avon Longitudinal Study of Parents and Children</subject><subject>Child</subject><subject>childhood asthma</subject><subject>Cohort Studies</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>eczema</subject><subject>Eczema - immunology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>hay fever</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Original</subject><subject>Pediatrics</subject><subject>Risk</subject><subject>Skin Tests</subject><subject>wheeze</subject><issn>0905-6157</issn><issn>1399-3038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNqNks1qFTEUx4Mo9np14QtIwI0u5jYfk8mMi8Kl-FEo6ELXIZOc6U3JTMZkpnV2PoLgG_ok5vbWooJgNoGcX345OfwRekrJhuZ1PGq3oYwKfg-tKG-aghNe30cr0hBRVFTII_QopUtCqOQVfYiOWMmapqzkCn3fDpNrXZicwfBlDGmOgN2Apx3gzsU04ek64AV0TDh02LsOsB4stnAFPow9DNP-XKdp1-ubSshXI9beQ7zIUusS6AQJtwuWG4GX-ApvsQ0Jfnz9ZmGEwe4dEbyeXBjSzo2P0YNO-wRPbvc1-vTm9cfTd8X5-7dnp9vzwoiS8cLYttMdUCKg1Q1URpfEdsR0ta2JZpbVkmlLKaemJaI0pq1rZqSwlWw1o5yv0cnBO85tD9bkPqL2aoyu13FRQTv1Z2VwO3URrlQesSCUZMGLW0EMn2dIk-pdMuC9HiDMSdGyYRWpCOf_gUophKxzu2v0_C_0MsxxyJPIVCVlJUSzf_vlgTIxpBShu-ubErVPhcqpUDepyOyz3z96R_6KQQaOD8C187D826Q-bM8Oyp90Z8S9</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Hoskin‐Parr, Lauren</creator><creator>Teyhan, Alison</creator><creator>Blocker, Ariel</creator><creator>Henderson, A. J. W.</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley & Sons Ltd</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201312</creationdate><title>Antibiotic exposure in the first two years of life and development of asthma and other allergic diseases by 7.5 yr: A dose‐dependent relationship</title><author>Hoskin‐Parr, Lauren ; Teyhan, Alison ; Blocker, Ariel ; Henderson, A. J. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5423-cdbfafe105eba9e6ca40df0cf8d80a2d2872ad1131cb054ccb882c75d67ba2133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age Factors</topic><topic>Allergies</topic><topic>Anti-Bacterial Agents - immunology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Asthma - immunology</topic><topic>atopy</topic><topic>Avon Longitudinal Study of Parents and Children</topic><topic>Child</topic><topic>childhood asthma</topic><topic>Cohort Studies</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>eczema</topic><topic>Eczema - immunology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>hay fever</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Original</topic><topic>Pediatrics</topic><topic>Risk</topic><topic>Skin Tests</topic><topic>wheeze</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoskin‐Parr, Lauren</creatorcontrib><creatorcontrib>Teyhan, Alison</creatorcontrib><creatorcontrib>Blocker, Ariel</creatorcontrib><creatorcontrib>Henderson, A. J. W.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoskin‐Parr, Lauren</au><au>Teyhan, Alison</au><au>Blocker, Ariel</au><au>Henderson, A. J. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibiotic exposure in the first two years of life and development of asthma and other allergic diseases by 7.5 yr: A dose‐dependent relationship</atitle><jtitle>Pediatric allergy and immunology</jtitle><addtitle>Pediatr Allergy Immunol</addtitle><date>2013-12</date><risdate>2013</risdate><volume>24</volume><issue>8</issue><spage>762</spage><epage>771</epage><pages>762-771</pages><issn>0905-6157</issn><eissn>1399-3038</eissn><abstract>Background
Antibiotic use in infancy disrupts gut microflora during a critical period for immune system development. It is hypothesized that this could predispose to the development of allergic diseases. We investigated the associations of antibiotic use in the first 2 yr of life with the development of asthma, eczema or hay fever by age 7.5 yr in a longitudinal birth cohort.
Methods
Subjects were 4952 children from the Avon Longitudinal Study of Parents and Children (ALSPAC). Child antibiotic use and asthma, eczema and hay fever symptoms were maternally reported. Atopy was assessed by skin prick tests at age 7.5 yr. The total number of antibiotic courses was considered as the main exposure. Data were analysed using multivariate logistic regression.
Results
Children reported to have taken antibiotics during infancy (0–2 yr) were more likely to have asthma at 7.5 yr (OR 1.75, 95% CI 1.40–2.17), and the odds (OR, [95% CI]) increased with greater numbers of courses: once 1.11 [0.84–1.48]; twice 1.50 [1.14–1.98]; three times 1.79 [1.34–2.40]; four times or more 2.82 [2.19–3.63]. Increased antibiotic use was also associated with higher odds of eczema and hay fever but not atopy. The effect appeared to be associated with cumulative rather than a critical period of exposure during the first 2 yr.
Conclusions
A robust and dose‐dependent association was found between antibiotic use in the first 2 yr of life and asthma at age 7.5 yr but did not appear to be mediated through an association with atopy.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>24299467</pmid><doi>10.1111/pai.12153</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pediatric allergy and immunology, 2013-12, Vol.24 (8), p.762-771 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Age Factors Allergies Anti-Bacterial Agents - immunology Anti-Bacterial Agents - therapeutic use Antibiotics Asthma - immunology atopy Avon Longitudinal Study of Parents and Children Child childhood asthma Cohort Studies Dose-Response Relationship, Immunologic eczema Eczema - immunology Epidemiology Female hay fever Humans Infant Infant, Newborn Longitudinal Studies Male Original Pediatrics Risk Skin Tests wheeze |
| title | Antibiotic exposure in the first two years of life and development of asthma and other allergic diseases by 7.5 yr: A dose‐dependent relationship |
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