Hydrogen Sulfide Improves Wound Healing via Restoration of Endothelial Progenitor Cell Functions and Activation of Angiopoietin-1 in Type 2 Diabetes

Impaired angiogenesis and its induced refractory wound lesions are common complications of diabetes. Hydrogen sulfide (H2S) has been reported to have proangiogenic effects. We hypothesize that H2S improves diabetic wound healing by restoring endothelial progenitor cell (EPC) function in type 2 diabe...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2014-05, Vol.63 (5), p.1763-1778
Hauptverfasser:	FANG LIU, CHEN, Dan-Dan, XIN SUN, XIE, He-Hui, HONG YUAN, JIA, Wei-Ping, CHEN, Alex F
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiopoietin-1 - metabolism Animals Biological and medical sciences Complications Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Disease Models, Animal Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium Etiopathogenesis. Screening. Investigations. Target tissue resistance Hydrogen sulfide Hydrogen Sulfide - pharmacology Hydrogen Sulfide - therapeutic use Medical sciences Mice Neovascularization, Physiologic - drug effects Protein expression Stem Cells - drug effects Stem Cells - metabolism Wound healing Wound Healing - drug effects
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