Growth factor transgenes interactively regulate articular chondrocytes

Adult articular chondrocytes lack an effective repair response to correct damage from injury or osteoarthritis. Polypeptide growth factors that stimulate articular chondrocyte proliferation and cartilage matrix synthesis may augment this response. Gene transfer is a promising approach to delivering...

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Veröffentlicht in:	Journal of cellular biochemistry 2013-04, Vol.114 (4), p.908-919
Hauptverfasser:	Shi, Shuiliang, Mercer, Scott, Eckert, George J., Trippel, Stephen B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ARTICULAR CHONDROCYTES Bone growth Bone Morphogenetic Protein 2 - genetics Bone Morphogenetic Protein 2 - metabolism Bone Morphogenetic Protein 7 - genetics Bone Morphogenetic Protein 7 - metabolism Cartilage, Articular - cytology Cartilage, Articular - metabolism Cattle Cell Differentiation Cell Proliferation Cells, Cultured Chondrocytes - cytology Chondrocytes - metabolism Collagen - biosynthesis DNA Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism Gene Expression Regulation GENE THERAPY Genetic Vectors - genetics Genetic Vectors - metabolism GROWTH FACTORS Humans Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism MATRIX Proteoglycans - metabolism Time Factors Transfection - methods Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Transgenes
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