AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells

Despite significant progress in the treatment of breast cancer, particularly through the use of targeted therapy, relapse and chemoresistance remain a major hindrance to the fight to minimize the burden of the disease. It is becoming increasingly clear that a rare subpopulation of cells known as can...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2014-03, Vol.33 (10), p.1316-1324
Hauptverfasser:	Asiedu, M K, Beauchamp-Perez, F D, Ingle, J N, Behrens, M D, Radisky, D C, Knutson, K L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/84/2176 692/699/67/1347 692/699/67/395 692/699/67/71 Animals Antineoplastic Agents - pharmacology Apoptosis Axl protein Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - pathology Cancer Carcinogenesis - metabolism Care and treatment Cell Biology Cell Line, Tumor Cell Movement Cell Proliferation Cell self-renewal Chemoresistance Drug Resistance, Neoplasm Epithelial cells Epithelial-Mesenchymal Transition Female Gene expression Gene regulation Genetic aspects Human Genetics Humans Internal Medicine Kinases Mammary gland Medicine Medicine & Public Health Mesenchyme Metastases Metastasis Mice Mice, Transgenic Molecular Targeted Therapy Neoplasm Transplantation Neoplastic processes Neoplastic Stem Cells - enzymology Neoplastic Stem Cells - physiology NF-kappa B - metabolism Oncology Oncology, Experimental original-article Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - physiology Pyrimidines - pharmacology Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - physiology Signal Transduction Stem cell transplantation Stem cells Treatment resistance Tumor Burden Tumorigenicity Tumors Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!