Cd2+-Induced Alteration of the Global Proteome of Human Skin Fibroblast Cells

Cadmium (Cd2+) is a toxic heavy metal and a well-known human carcinogen. The toxic effects of Cd2+ on biological systems are diverse and thought to be exerted through a complex array of mechanisms. Despite the large number of studies aimed to elucidate the toxic mechanisms of action of Cd2+, few hav...

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Veröffentlicht in:	Journal of proteome research 2014-03, Vol.13 (3), p.1677-1687
Hauptverfasser:	Prins, John M, Fu, Lijuan, Guo, Lei, Wang, Yinsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - analysis Amidohydrolases - genetics Amidohydrolases - metabolism Amino Acid Sequence amino acids antioxidants biosynthesis cadmium Cadmium Chloride - toxicity carcinogens cell culture Cell Line energy metabolism fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Gene Expression Regulation glutathione glutathione peroxidase glutathione synthase glutathione transferase glycolysis heavy metals homeostasis Humans Isotope Labeling liquid chromatography Lung - cytology Lung - drug effects Lung - metabolism lungs mechanism of action Metabolic Networks and Pathways - drug effects Molecular Sequence Annotation Molecular Sequence Data nitric oxide Nitric Oxide - agonists Nitric Oxide - biosynthesis pentose phosphate cycle Protein Interaction Mapping proteins proteome Proteome - analysis Proteome - genetics Proteome - metabolism proteomics skin (animal) Skin - cytology Skin - drug effects Skin - metabolism stable isotopes superoxide dismutase tandem mass spectrometry toxicity tricarboxylic acid cycle
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