TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice

Cleavage of the hemagglutinin (HA) by host proteases is essential for the infectivity of influenza viruses. Here, we analyzed the role of the serine protease TMPRSS2, which activates HA in the human respiratory tract, in pathogenesis in a mouse model. Replication of the human H7N9 isolate A/Anhui/1/...

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Veröffentlicht in:	Journal of virology 2014-05, Vol.88 (9), p.4744-4751
Hauptverfasser:	Tarnow, Carolin, Engels, Géraldine, Arendt, Annika, Schwalm, Folker, Sediri, Hanna, Preuss, Annette, Nelson, Peter S, Garten, Wolfgang, Klenk, Hans-Dieter, Gabriel, Gülsah, Böttcher-Friebertshäuser, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Structures - virology Animals Host-Pathogen Interactions Influenza A virus Influenza A Virus, H1N1 Subtype - physiology Influenza A Virus, H3N2 Subtype - physiology Influenza A Virus, H7N9 Subtype - pathogenicity Influenza A Virus, H7N9 Subtype - physiology Influenza virus Lung - virology Mice Mice, Knockout Organ Culture Techniques Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - virology Pathogenesis and Immunity Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Survival Analysis Trachea - virology Viral Tropism Virulence
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