Attenuating mutations in nsP1 reveal tissue-specific mechanisms for control of Ross River virus infection

Ross River virus (RRV) is one of a group of mosquito-transmitted alphaviruses that cause debilitating, and often chronic, musculoskeletal disease in humans. Previously, we reported that replacement of the nonstructural protein 1 (nsP1) gene of the mouse-virulent RRV strain T48 with that from the mou...

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Veröffentlicht in:	Journal of virology 2014-04, Vol.88 (7), p.3719-3732
Hauptverfasser:	Stoermer Burrack, Kristina A, Hawman, David W, Jupille, Henri J, Oko, Lauren, Minor, Marissa, Shives, Katherine D, Gunn, Bronwyn M, Long, Kristin M, Morrison, Thomas E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alphavirus Alphavirus Infections - pathology Alphavirus Infections - virology Animal Structures - virology Animals Disease Models, Animal DNA Mutational Analysis Host-Pathogen Interactions Interferon Type I - immunology Mice Mice, Inbred C57BL Mice, Knockout Mutant Proteins - genetics Mutant Proteins - metabolism Mutation, Missense Pathogenesis and Immunity Ross River virus Ross River virus - immunology Ross River virus - pathogenicity Viral Load Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Virulence Virulence Factors - genetics Virulence Factors - metabolism
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