An ethA-ethR-deficient Mycobacterium bovis BCG mutant displays increased adherence to mammalian cells and greater persistence in vivo, which correlate with altered mycolic acid composition

Tuberculosis remains a major worldwide epidemic because of its sole etiological agent, Mycobacterium tuberculosis. Ethionamide (ETH) is one of the major antitubercular drugs used to treat infections with multidrug-resistant M. tuberculosis strains. ETH is a prodrug that requires activation within th...

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Veröffentlicht in:	Infection and immunity 2014-05, Vol.82 (5), p.1850-1859
Hauptverfasser:	Ang, Michelle Lay Teng, Zainul Rahim, Siti Zarina, Siti, Zarina Zainul Rahim, Shui, Guanghou, Dianiškova, Petronela, Madacki, Jan, Lin, Wenwei, Koh, Vanessa Hui Qi, Martinez Gomez, Julia Maria, Sudarkodi, Sukumar, Bendt, Anne, Wenk, Markus, Mikušová, Katarína, Korduláková, Jana, Pethe, Kevin, Alonso, Sylvie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Adhesion - physiology Bacterial Infections Cell Line Cell Wall Female Gene Deletion Gene Expression Regulation, Bacterial - physiology Humans Mice Mice, Inbred BALB C Microbial Sensitivity Tests Mutation Mycobacterium bovis Mycobacterium bovis - genetics Mycobacterium bovis - metabolism Mycobacterium tuberculosis Mycolic Acids - metabolism Oxidative Stress Oxidoreductases - genetics Oxidoreductases - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Specific Pathogen-Free Organisms
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