Pulmonary and Systemic Pharmacokinetics of Inhaled and Intravenous Colistin Methanesulfonate in Cystic Fibrosis Patients: Targeting Advantage of Inhalational Administration

The purpose of this study was to define the pulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and formed colistin following intravenous (i.v.) and inhaled administration in cystic fibrosis (CF) patients. Six CF subjects were administered nebulized CMS doses of 2 and 4 millio...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2014-05, Vol.58 (5), p.2570-2579
Hauptverfasser:	YAPA, Shalini W. S, JIAN LI, NATION, Roger L, MCINTOSH, Michelle P, PATEL, Kashyap, WILSON, John W, DOOLEY, Michael J, GEORGE, Johnson, CLARK, Denise, POOLE, Susan, WILLIAMS, Elyssa, PORTER, Christopher J. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aged Aged, 80 and over Anti-Bacterial Agents Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Clinical Therapeutics Colistin Colistin - administration & dosage Colistin - analogs & derivatives Colistin - metabolism Colistin - pharmacokinetics Cystic Fibrosis Cystic Fibrosis - metabolism Errors of metabolism Female Humans Lung Lung - metabolism Male Medical sciences Metabolic diseases Middle Aged Miscellaneous hereditary metabolic disorders Pharmacology. Drug treatments Sputum - chemistry
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