Elucidation of Cellular Mechanisms Involved in Experimental Paromomycin Resistance in Leishmania donovani

Leishmania donovani is the causative agent of the potentially fatal disease visceral leishmaniasis (VL). Chemotherapeutic options available to treat VL are limited and often face parasite resistance, inconsistent efficacy, and toxic side effects. Paromomycin (PMM) was recently introduced to treat VL...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2014-05, Vol.58 (5), p.2580-2585
Hauptverfasser:	BHANDARI, Vasundhra, SUNDAR, Shyam, DUJARDIN, Jean Claude, SALOTRA, Poonam
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiprotozoal Agents Antiprotozoal Agents - pharmacology ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological and medical sciences Enzyme-Linked Immunosorbent Assay Interleukin-10 - metabolism Leishmania donovani Leishmania donovani - drug effects Leishmania donovani - metabolism Mechanisms of Resistance Medical sciences Oxidative Stress - drug effects Oxidative Stress - genetics Paromomycin Paromomycin - pharmacology Pharmacology. Drug treatments Real-Time Polymerase Chain Reaction
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