S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment

Defects in CFTR (cystic fibrosis transmembrane conductance regulator) maturation are central to the pathogenesis of CF (cystic fibrosis). Palmitoylation serves as a key regulator of maturational processing in other integral membrane proteins, but has not been tested previously for functional effects...

Ausführliche Beschreibung